The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Myeloid-derived suppressor cells coming of age
Open accessAbstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of genomic and biochemical features, and can, on the basis of recent findings, be distinguished by specific surface molecules. The salient feature of these cells is their ability to inhibit T cell function and thus contribute to the pathogenesis of various diseases. In this Review, we discuss the origin and nature of these cells; their distinctive features; and their biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy. Gabrilovich and colleagues review the origin and nature of myeloid-derived suppressor cells, as well as their distinctive features and biological roles in cancer, infectious diseases, autoimmunity, obesity and pregnancy.
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Cites
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Cited by
Inflammation and cancer: triggers, mechanisms, and consequences
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Metadata
- Authors
- Veglia, F., Perego, M., & Gabrilovich, D.
- Venue
- Nature Immunology
- Published
- 2018-01-18
- Volume
- 19
- Issue
- 2
- Pages
- 108-119
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2782485041
- Cited by
- 1,767
- References
- 173
- FWCI
- 69.85
- Type
- journal article
- Language
- en
- Open access
- green
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