The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Recurrent infections and immune evasion strategies of Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus causes purulent skin and soft tissue infections (SSTIs) that frequently reoccur. Staphylococal SSTIs can lead to invasive disease and sepsis, which are among the most significant causes of infectious disease mortality in both developed and developing countries. Human or animal infections with S. aureus do not elicit protective immunity against staphylococcal diseases. Here we review what is known about the immune evasive strategies of S. aureus that enable the pathogen’s escape from protective immune responses. Three secreted products are discussed in detail, staphylococcal protein A (SpA), staphylococcal binder of immunoglobulin (Sbi) and adenosine synthase A (AdsA). By forming a complex with VH3-type IgM on the surface of B cells, SpA functions as a superantigen to modulate antibody responses to staphylococcal infection. SpA also captures pathogen-specific antibodies by binding their Fcγ portion. The latter activity of SpA is shared by Sbi, which also associates with complement factors 3d and factor H to promote the depletion of complement. AdsA synthesizes the immune signaling molecule adenosine, thereby dampening innate and adaptive immune responses during infection. We discuss strategies how the three secreted products of staphylococci may be exploited for the development of vaccines and therapeutics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
Cheng, A. G., Kim, H. K., Burts, M. L., Krausz, T., Schneewind, O., & Missiakas, D. M. (2009) · The FASEB Journal · doi:10.1096/fj.09-135467 · Cited by 437
Self-citationRetractedKlevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · cited 1×
“Because of the severity of invasive disease, MRSA infections are associated with a poor outcome even when appropriate antibiotic therapies have been implemented [7,8].”
BackgroundThe crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834 · cited 1×
“aureus strains have evolved resistance against the most abundantly used therapeutics [3].”
BackgroundStaphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
Mazmanian, S. K., Liu, G., Ton-That, H., & Schneewind, O. (1999) · Science · doi:10.1126/science.285.5428.760 · Cited by 1,053
Self-citationvan Wamel, W. J. B., Rooijakkers, S. H. M., Ruyken, M., van Kessel, K. P. M., & van Strijp, J. A. G. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.4.1310-1315.2006 · Cited by 579
Insights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Gómez, M. I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., Cheung, A., & Prince, A. (2004) · Nature Medicine · doi:10.1038/nm1079 · Cited by 412
Vaccine assembly from surface proteins of Staphylococcus aureus
Stranger-Jones, Y. K., Bae, T., & Schneewind, O. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606863103 · Cited by 309
Self-citationPatel, A. H., Nowlan, P., Weavers, E. D., & Foster, T. (1987) · Infection and Immunity · doi:10.1128/iai.55.12.3103-3110.1987 · Cited by 280
Kuklin, N. A., Clark, D. J., Secore, S., Cook, J., Cope, L. D., McNeely, T., Noble, L., Brown, M. J., Zorman, J. K., Wang, X. M., et al. (2006) · Infection and Immunity · doi:10.1128/iai.74.4.2215-2223.2006 · Cited by 264
Cited by
Bacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
Masters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575
Staphylococcus aureus Secreted Toxins and Extracellular Enzymes
Tam, K., & Torres, V. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0039-2018 · Cited by 452
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
Alonzo, F., & Torres, V. J. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-13 · Cited by 276
Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections
Romeo, L., Iori, R., Rollin, P., Bramanti, P., & Mazzon, E. (2018) · Molecules · doi:10.3390/molecules23030624 · Cited by 230
Metadata
- Authors
- Kim, H. K., Thammavongsa, V., Schneewind, O., & Missiakas, D.
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 15
- Issue
- 1
- Pages
- 92-99
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2076668689
- Cited by
- 221
- References
- 10
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Recurrent infections and immune evasion strategies of Staphylococcus aureus. https://app.cochat.ai/papers/10.1016/j.mib.2011.10.012
- The paper
- Kim, H. K., Thammavongsa, V., Schneewind, O., & Missiakas, D. (2012). Recurrent infections and immune evasion strategies of Staphylococcus aureus. Current Opinion in Microbiology. https://doi.org/10.1016/j.mib.2011.10.012
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
