The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Viral pathogen discovery
Open accessAbstract
Viral pathogen discovery is of critical importance to clinical microbiology, infectious diseases, and public health. Genomic approaches for pathogen discovery, including consensus polymerase chain reaction (PCR), microarrays, and unbiased next-generation sequencing (NGS), have the capacity to comprehensively identify novel microbes present in clinical samples. Although numerous challenges remain to be addressed, including the bioinformatics analysis and interpretation of large datasets, these technologies have been successful in rapidly identifying emerging outbreak threats, screening vaccines and other biological products for microbial contamination, and discovering novel viruses associated with both acute and chronic illnesses. Downstream studies such as genome assembly, epidemiologic screening, and a culture system or animal model of infection are necessary to establish an association of a candidate pathogen with disease.
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Cites
RNA-Seq: a revolutionary tool for transcriptomics
Wang, Z., Gerstein, M., & Snyder, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2484 · Cited by 13,174
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Accelerated Profile HMM Searches
Eddy, S. R. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002195 · Cited by 6,975
Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
Feng, H., Shuda, M., Chang, Y., & Moore, P. S. (2008) · Science · doi:10.1126/science.1152586 · Cited by 3,208
Quail, M., Smith, M. E., Coupland, P., Otto, T. D., Harris, S. R., Connor, T. R., Bertoni, A., Swerdlow, H. P., & Gu, Y. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-341 · Cited by 2,031 · cited 1×
“Other NGS technologies, such as platforms by Ion Torrent (very fast run times of under three hours) and Pacific Biosciences (very long reads of up to 7 kb; average read lengths 3–4 kb) [88], have yet to be used widely for pathogen discovery, although one application may be rapid genome sequencing of emerging pathogens…”
Lanciotti, R. S., Roehrig, J. T., Deubel, V., Smith, J., Parker, M., Steele, K., Crise, B., Volpe, K. E., Crabtree, M. B., Scherret, J. H., et al. (1999) · Science · doi:10.1126/science.286.5448.2333 · Cited by 1,593
Gnirke, A., Melnikov, A., Maguire, J., Rogov, P., LeProust, E. M., Brockman, W., Fennell, T., Giannoukos, G., Fisher, S., Russ, C., et al. (2009) · Nature Biotechnology · doi:10.1038/nbt.1523 · Cited by 1,433 · cited 1×
“Another complementary approach is to perform target enrichment using biotinylated probes to enrich NGS libraries for sequences corresponding to pathogens, akin to now well-established techniques that have been developed in the cancer field [85].”
BackgroundWildlife, Exotic Pets, and Emerging Zoonoses1
Chomel, B. B., Belotto, A., & Meslin, F.-X. (2007) · Emerging Infectious Diseases · doi:10.3201/eid1301.060480 · Cited by 551
Victoria, J. G., Wang, C., Jones, M. S., Jaing, C., McLoughlin, K., Gardner, S., & Delwart, E. L. (2010) · Journal of Virology · doi:10.1128/jvi.02690-09 · Cited by 342
Multiple Novel Astrovirus Species in Human Stool
Kapoor, A., Li, L., Victoria, J., Oderinde, B., Mason, C., Pandey, P., Zaidi, S. Z., & Delwart, E. (2009) · Journal of General Virology · doi:10.1099/vir.0.014449-0 · Cited by 241 · cited 1×
“This approach was recently used to identify novel paramyxoviruses in samples from large-scale surveys of bats and rodents [20–22] and emerging viruses such as coronavirus EMC, the cause of a new severe and occasionally fatal respiratory disease in the Middle East and Europe [6], although many other examples of this st…”
Method
Cited by
Chiu, C. Y., & Miller, S. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0113-7 · Cited by 1,620
Self-citationClinical Metagenomic Next-Generation Sequencing for Pathogen Detection
Gu, W., Miller, S., & Chiu, C. Y. (2019) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012751 · Cited by 1,458
Self-citationActionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing
Wilson, M. R., Naccache, S. N., Samayoa, E., Biagtan, M., Bashir, H., Yu, G., Salamat, S. M., Somasekar, S., Federman, S., Miller, S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401268 · Cited by 977
Self-citationMiller, S., Naccache, S. N., Samayoa, E., Messacar, K., Arevalo, S., Federman, S., Stryke, D., Pham, E., Fung, B., Bolosky, W. J., et al. (2019) · Genome Research · doi:10.1101/gr.238170.118 · Cited by 572
Self-citationGreninger, A. L., Naccache, S. N., Federman, S., Yu, G., Mbala, P., Bres, V., Stryke, D., Bouquet, J., Somasekar, S., Linnen, J. M., et al. (2015) · Genome Medicine · doi:10.1186/s13073-015-0220-9 · Cited by 558
Self-citation
Metadata
- Authors
- Chiu, C. Y.
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 16
- Issue
- 4
- Pages
- 468-478
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2111664429
- Cited by
- 234
- References
- 12
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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