Multiple Novel Astrovirus Species in Human Stool
Open accessAbstract
Diarrhoea remains a significant cause of morbidity and mortality in developing countries where numerous cases remain without identified aetiology. Astroviruses are a recently identified cause of animal gastroenteritis which currently includes two species suspected of causing human diarrhoea. Using pan-astrovirus RT-PCR, we analysed human stool samples from different continents for astrovirus-related RNA sequences. We identified variants of the two known human astrovirus species plus, based on genetic distance criteria, three novel astrovirus species all distantly related to mink and ovine astroviruses, which we provisionally named HMOAstV species A–C. The complete genome of species A displayed all the conserved characteristics of mammalian astroviruses. Each of the now three groups of astroviruses found in human stool (HAstV, AstV-MLB and HMOAstV) were more closely related to animal astroviruses than to each other, indicating that human astroviruses may periodically emerge from zoonotic transmissions. Based on the pathogenic impact of their closest phylogenetic relatives in animals, further investigations of the role of HMOAstV, so far detected in Nigeria, Nepal and Pakistan, in human gastroenteritis are warranted.
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Some human astroviruses are more closely related to those in animals than to each other, suggesting that these viruses periodically emerge from zoonotic origins.
“Some human astroviruses are more closely related to those in animals than to each other, suggesting that these viruses periodically emerge from zoonotic origins (Kapoor et al. 2009).”
From Red fox viromes in urban and rural landscapes (2020) · cites this paper as Kapoor et al. 2009
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BackgroundSelf-citationAstrovirus evolution and emergence
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“However, it is w clear that multiple AstV lineages can infect the same imal species and there is also growing evidence that tVs can cross the species barrier (Chu et al., 2008; Zhu al., 2009; Kapoor et al., 2009).”
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“With the development of tools for pathogen discovery, previously unknown astroviruses such as HuAstV-MLB (28), HuAstV-VA1 (29), and human-mink-ovine-like astrovirus (HMO-AstV) (30) have been identified.”
MethodDetection of novel astroviruses in urban brown rats and previously known astroviruses in humans
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“, 2009a, c) and HMO astroviruses (Kapoor et al., 2009), none of these The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are HM450380–HM450386.”
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“The HAstV‐VA1–VA3 viruses were first discovered in an outbreak of gastroenteritis in Virginia, USA [44,45]; HAstV‐VA4 in a cohort of Indian children with diarrhea [43]; and HAstV‐VA5 in a cohort in Gambia [46].”
BackgroundInfluentialNovel human astroviruses: Novel human diseases?
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A novel astrovirus associated with encephalitis and ganglionitis in domestic sheep
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“The Mamastrovirus cluster was further divided into genogroup I, containing classical strains, and genogroup II, encompassing the humanmink-ovine (HMO) strain complex (Kapoor et al., 2009) as well as the BoAstV CH13/NeuroS1 strains (Bouzalas et al.”
BackgroundViruses Causing Gastroenteritis: The Known, The New and Those Beyond
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“The first clade consists of the VA-1, VA-2, VA-3, VA-4, and VA-5 astroviruses, which are genetically related to feline and porcine astroviruses, while the second clade consists of the MLB1, MLB2 and MLB3 astroviruses and form a separate cluster [55, 57, [74] [75] [76] [77] [78] .”
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Use of Nucleotide Composition Analysis To Infer Hosts for Three Novel Picorna-Like Viruses
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“Stools are known to contain viruses that infect host cells and/or bacteriophages, as well as viruses of dietary origins from consumed plants, insects, and animals (3, 4, 16, 17, 27, 36, 38).”
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“We identified the conserved proteolytic cleavage site (V561HQ ̄TNT) of serine protease (ORF1a) and the conserved Y358GDD motif of the RdRp (ORF1b) (33).”
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“VA2 and VA3 were identified in a cohort of children with diarrhea in India (Finkbeiner et al., 2009a); HMO-A, B, ll rights reserved. icrobiology and Pathology & icine 660 S. Euclid Ave. St. Wang). and C were simultaneously described in stools from Nigeria, Pakistan and Nepal (Kapoor et al., 2009).”
BackgroundBurbelo, P., Ching, K. H., Esper, F. L., Iadarola, M., Delwart, E., Lipkin, W., & Kapoor, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022576 · Cited by 79 · see citing works
“In addition, a new group of astroviruses, provisionally named HMOAstV/AstV-VA, were discovered by consensus PCR using stool samples from different continents [13,18].”
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“Because t(10;11) is associated with a high risk of disease relapse, she had a fully human leukocyte antigenmatched unrelated donor bone marrow transplant in first remission at 8 months old.”
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“A close genetic relationship or interspecies transmission of different viruses in the SaV, AstV, and KoV genera has been documented [16, 18, 24, 30].”
BackgroundIdentification of a novel astrovirus in a domestic pig in Hungary
Reuter, G., Pankovics, P., & Boros, Á. (2010) · Archives of Virology · doi:10.1007/s00705-010-0827-5 · Cited by 67 · see citing works
“Interestingly, multiple lineages of astroviruses have been identified in humans (classical HAstV, HAstV-MLB and HMOAstV), phylogenetically separated by different lineages of animal astroviruses [8].”
BackgroundInfluentialIntra- and Cross-Species Transmission of Astroviruses
Roach, S. N., & Langlois, R. (2021) · Viruses · doi:10.3390/v13061127 · Cited by 64 · see citing works
“The human, mink, ovine-like (HMO) AstVs that infect humans (Table 1) are more closely related to mink and ovine viruses (40–45% ORF2 amino acid identity) than the classical HAstVs (23–25% ORF2 amino acid identity) [58], suggesting these viruses emerged from these animal reservoirs after close interactions with humans.”
BackgroundDelwart, E. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.012 · Cited by 59 · see citing works
Self-citationAstrovirus MLB1 Is Not Associated with Diarrhea in a Cohort of Indian Children
Holtz, L. R., Bauer, I. K., Rajendran, P., Kang, G., & Wang, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028647 · Cited by 63
“Subsequently, it has been found in stools collected from around the world [9,11,12,13,14,15] from patients with and without diarrhea.”
BackgroundEvidence of a Recombinant Wild-Type Human Astrovirus Strain from a Kenyan Child with Gastroenteritis
Wolfaardt, M., Kiulia, N., Mwenda, J., & Taylor, M. B. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01093-10 · Cited by 63 · see citing works
“(12) and the occurrence of HAstV recombinants may have a”
BackgroundDetection and genetic characterization of a novel pig astrovirus: relationship to other astroviruses
Laurin, M., Dastor, M., & L'Homme, Y. (2011) · Archives of Virology · doi:10.1007/s00705-011-1088-7 · Cited by 57
“In addition, a number of genetically distinct strains of HuAstV have recently been identified, characterized and proposed to represent novel AstV species based on genetic distance criteria [8, 15].”
BackgroundMolecular characterization of a porcine astrovirus strain in China
Lan, D.-L., Ji, W., Shan, T., Cui, L., Yang, Z.-B., Yuan, C.-L., & Hua, X.-G. (2011) · Archives of Virology · doi:10.1007/s00705-011-1050-8 · Cited by 57
“It has even been found in equine rhinoviruses, coronaviruses, and dog noroviruses [4, 12].”
BackgroundAstrovirus as a possible cause of congenital tremor type AII in piglets?
Blomström, A., Ley, C., & Jacobson, M. (2014) · Acta Veterinaria Scandinavica · doi:10.1186/s13028-014-0082-y · Cited by 56 · see citing works
“The samples were screened for the presence of AstV by a nested pan-AstV PCR [17] designed to target a conserved region of the RNA-dependent-RNA polymerase (RdPp) gene that have previously been shown to efficiently identify AstV in humans [18], bats [17] and pigs [19,20].”
MethodNovel goose-origin astrovirus infection in geese: the effect of age at infection
An, D., Zhang, J., Yang, J., Tang, Y., & Diao, Y. (2020) · Poultry Science · doi:10.1016/j.psj.2020.05.041 · Cited by 55 · see citing works
“Ranging from 6,100 to 7,900 nt in length, the genomes of these viruses are arranged in 3 open reading frames (ORF) (ORF1a, ORF1b, and ORF2), as well as a short 50-untranslated region, a 30-untranslated region, and a polyA tail (Kapoor et al., 2009; Wan et al., 2018).”
BackgroundReuter, G., Pankovics, P., & Boros, Á. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00040-18 · Cited by 49 · see citing works
“Finally, the MAstV9 species includes astrovirus clades VA1 (or HMO-C) (23) and VA3 (or HMO-B) (19, 21, 24).”
Identification and characterization of deer astroviruses.
Smits, S., van Leeuwen, M., Kuiken, T., Hammer, A., Simon, J., & Osterhaus, A. (2010) · Journal of General Virology · doi:10.1099/vir.0.024067-0 · Cited by 49 · see citing works
“To determine whether astroviruses are present in the deer faecal samples, a degenerate RT-PCR assay using primers that target conserved motifs in the RdRP gene of diverse astroviruses (Kapoor et al., 2009) was used (Fig.”
MethodResultJaphet, M. O., Famurewa, O., Adesina, O. A., Opaleye, O., Wang, B., Höhne, M., Bock, C., Marques, A. M., & Niendorf, S. (2019) · Journal of Clinical Virology · doi:10.1016/j.jcv.2018.12.004 · Cited by 48 · see citing works
Red fox viromes in urban and rural landscapes
Campbell, S. J., Ashley, W., Gil-Fernandez, M., Newsome, T. M., Di Giallonardo, F., Ortiz-Baez, A. S., Mahar, J. E., Towerton, A. L., Gillings, M., Holmes, E. C., et al. (2020) · Virus Evolution · doi:10.1093/ve/veaa065 · Cited by 47 · see citing works
Šalamúnová, S., Jacková, A., Mandelík, R., Novotný, J., Vlasáková, M., & Vilcek, S. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1640-8 · Cited by 45 · see citing works
Jacobsen, S., Höhne, M., Marques, A. M., Beslmüller, K., Bock, C., & Niendorf, S. (2018) · Journal of Infection · doi:10.1016/j.jinf.2018.02.006 · Cited by 45 · see citing works
Propagation of Astrovirus VA1, a Neurotropic Human Astrovirus, in Cell Culture
Janowski, A. B., Bauer, I. K., Holtz, L. R., & Wang, D. (2017) · Journal of Virology · doi:10.1128/jvi.00740-17 · Cited by 45
Viral hijacking of host caspases: an emerging category of pathogen–host interactions
Connolly, P. F., & Fearnhead, H. O. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.59 · Cited by 44 · see citing works
“They are divided into two genera; the Avastroviridae which infect birds, and the Mamastroviridae which infect mammals.(69) They are the causative agent of some forms of viral gastroenteritis.”
BackgroundPérot, P., Lecuit, M., & Eloit, M. (2017) · Viruses · doi:10.3390/v9010010 · Cited by 43 · see citing works
Martella, V., Moschidou, P., Pinto, P., Catella, C., Desario, C., Larocca, V., Circella, E., Bányai, K., Lavazza, A., Magistrali, C., et al. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1712.110967 · Cited by 43
Bat Astroviruses: Towards Understanding the Transmission Dynamics of a Neglected Virus Family
Fischer, K., dos Reis, V. P., & Balkema-Buschmann, A. (2017) · Viruses · doi:10.3390/v9020034 · Cited by 42 · see citing works
“The majority of the detected astrovirus sequences clustered with classic HAstV, whereas four sequences from Nigeria were most closely related with previously described AstV-MLB1 [66].”
BackgroundInfluentialNew astrovirus in human feces from Burkina Faso
Phan, T., Nordgren, J., Ouermi, D., Simporé, J., Nitiéma, L., Deng, X.-T., & Delwart, E. (2014) · Journal of Clinical Virology · doi:10.1016/j.jcv.2014.03.024 · Cited by 42 · see citing works
“(mamastrovirus 8) was reported in 2009 with strains VA2 [3] and HMO-A [4].”
BackgroundSelf-citationPorcine astrovirus viremia and high genetic variability in pigs on large holdings in Croatia.
Brnić, D., Prpić, J., Keros, T., Roić, B., Starešina, V., & Jemeršić, L. (2013) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.12.027 · Cited by 42 · see citing works
Martella, V., Pinto, P., Tummolo, F., Grazia, S. D., Giammanco, G., Medici, M., Ganesh, B., L'Homme, Y., Farkas, T., Jakab, F., et al. (2014) · Archives of Virology · doi:10.1007/s00705-014-2153-9 · Cited by 40 · see citing works
“A number of unusual HAstVs discovered recently are genetically more closely related to animal AstVs than to ‘‘canonical’’ HAstVs [3, 16, 17, 26, 28, 39].”
BackgroundIdentification of a novel astrovirus in domestic sheep in Hungary
Reuter, G., Pankovics, P., Delwart, E., & Boros, Á. (2011) · Archives of Virology · doi:10.1007/s00705-011-1151-4 · Cited by 40 · see citing works
“Interestingly, multiple lineages of astroviruses have been identified in humans (classical HAstV, HAstV-MLB and HMOAstV), and these are phylogenetically separated by different lineages of animal astroviruses [3, 10].”
BackgroundSelf-citationMajumdar, M., & Martín, J. E.-S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01956 · Cited by 42 · see citing works
Molecular detection of Porcine astrovirus in Sichuan Province, China
Cai, Y.-H., Yin, W., Zhou, Y.-C., Li, B., Ai, L., Pan, M., & Guo, W.-Z. (2016) · Virology Journal · doi:10.1186/s12985-015-0462-6 · Cited by 39
“The fecal samples were initially examined for the presence of PoAstV with a nested pan-PCR [12] designed to target a conserved region of the RNA-dependent RNA polymerase (RdRp) gene, which has been used previously for the sensitive and specific identification of AstV in mammals, including humans [13], pigs [1, 2, 6, 9…”
MethodNovel Astroviruses in Children, Egypt
Ahmed, S. F., Sebeny, P., Klena, J., Pimentel, G., Mansour, A., Naguib, A., Bruton, J., Young, S. Y., Holtz, L. R., & Wang, D. (2011) · Emerging Infectious Diseases · doi:10.3201/eid1712.110909 · Cited by 38 · see citing works
Hata, A., Kitajima, M., Haramoto, E., Lee, S., Ihara, M., Gerba, C., & Tanaka, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-30217-y · Cited by 37
Alam, M., Khurshid, A., Shaukat, S., Rana, M. S., Sharif, S., Angez, M., Nisar, N., Aamir, U. B., Naeem, M., & Zaidi, S. S. (2015) · Viruses · doi:10.3390/v7010378 · Cited by 37 · see citing works
“In humans, eight well-characterized AstV serotypes (HAstV 1–8) have been reported, in addition to the newly identified species, AstV MLB-1 and 2, AstV-VA1, AstV-HMO-A, and AstV-HMO-B [14].”
BackgroundSelf-citationPativada, M., Nataraju, S. M., Ganesh, B., Rajendran, K., Ramamurthy, T., Ganguly, S., Bhattacharya, M., Ghosh, M., Kobayashi, N., & Krishnan, T. (2012) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.07.018 · Cited by 38 · see citing works
“Three novel human astrovirus species (HMOAstV-A-B-C) found in human stool samples showed close genetic relatedness to mink and bovine astroviruses (Kapoor et al., 2009).”
BackgroundHigh evolutionary rate of human astrovirus.
Babkin, I., Tikunov, A., Zhirakovskaia, E., Netesov, S., & Tikunova, N. (2012) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2012.01.019 · Cited by 37 · see citing works
The Expanding Field of Mammalian Astroviruses: Opportunities and Challenges in Clinical Virology.
Boujon, C. L., Koch, M., & Seuberlich, T. (2017) · Advances in Virus Research · doi:10.1016/bs.aivir.2017.07.002 · Cited by 37 · see citing works
Cordey, S., Brito, F., Vu, D., Turin, L., Kilowoko, M., Kyungu, E., Genton, B., Zdobnov, E., D'Acremont, V., & Kaiser, L. (2016) · Emerging Microbes and Infections · doi:10.1038/emi.2016.98 · Cited by 35
Prevalence and risk factors of astrovirus infection in puppies from French breeding kennels.
Grellet, A., de Battisti, C., Feugier, A., Pantile, M., Marciano, S., Grandjean, D., & Cattoli, G. (2012) · Veterinary Microbiology · doi:10.1016/j.vetmic.2011.11.012 · Cited by 34 · see citing works
Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus
Xavier, M. D. P. T. P., Costa, F. A. C., Rocha, M., de Andrade, J. D. S. R., Diniz, F. B., de Andrade, T. R., Miagostovich, M., Leite, J. P., & Volotão, E. D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135687 · Cited by 33
“The recent identification of novel AstV in humans using highly sensitive methods [9–13], highlights the need to analyze the prevalence of these viruses to recognize their actual impact in public health, since they were found to be genetically related to animal viruses and some were isolated from patients with more sev…”
BackgroundMethodAstrovirus infection in hospitalized children: Molecular, clinical and epidemiological features.
Siqueira, J. A., Oliveira, D. D. S., Carvalho, T. C. D. D., Portal, T. M., Justino, M. C., da Silva, L. D., Resque, H. R., & Gabbay, Y. (2017) · Journal of Clinical Virology · doi:10.1016/j.jcv.2017.07.014 · Cited by 32
The Diversity of Human RNA Viruses
Woolhouse, M. E. J., & Adair, K. (2013) · Future Virology · doi:10.2217/fvl.12.129 · Cited by 42 · see citing works
Hata, A., Katayama, H., Kitajima, M., & Furumai, H. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.00563-15 · Cited by 31 · see citing works
“A previous clinical study reported the less frequent detection of MLB-AstV, but the study investigated samples from adults with diarrhea and children without diarrhea (20).”
BackgroundInfluentialDetection of a mammalian-like astrovirus in bird, European roller (Coracias garrulus).
Pankovics, P., Boros, Á., Kiss, T., Delwart, E., & Reuter, G. (2015) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2015.06.020 · Cited by 30 · see citing works
“Astroviruses were screened by RT-PCR using a common screening (Chu et al., 2008; Kapoor et al., 2009) and strain specific (SZAL6A-scr-R: 50-GGCTTTACCCACATACCAAA-30, SZAL6A-scr-F: 50 -GAGTTTGACTGGACCCGTTTTGA-30) primer pairs.”
MethodSelf-citationFarahmand, M., Khales, P., Salavatiha, Z., Sabaei, M., Hamidzade, M., Aminpanah, D., & Tavakoli, A. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106209 · Cited by 29
A Novel Astrovirus-Like RNA Virus Detected in Human Stool
Munnink, B. O., Cotten, M., Canuti, M., Deijs, M., Jebbink, M., van Hemert, F. V., Phan, M. V. T., Bakker, M., Farsani, S. M. J., Kellam, P., et al. (2016) · Virus Evolution · doi:10.1093/ve/vew005 · Cited by 29 · see citing works
A novel astrovirus from dromedaries in the Middle East.
Woo, P. C. Y., Lau, S., Teng, J. L. L., Tsang, A. K. L., Joseph, S., Xie, J., Jose, S., Fan, R. Y. Y., Wernery, U., & Yuen, K. Y. (2015) · Journal of General Virology · doi:10.1099/jgv.0.000233 · Cited by 29 · see citing works
Afrad, M. H., Karmakar, P. C., Das, S., Matthijnssens, J., Ahmed, F., Nahar, S., Faruque, A. G., Rahman, M. Z., Rahman, M., & Azim, T. (2013) · Journal of Clinical Virology · doi:10.1016/j.jcv.2013.09.028 · Cited by 28
Call to Action for Dengue Vaccine Failure
Mahalingam, S., Herring, B., & Halstead, S. (2013) · Emerging Infectious Diseases · doi:10.3201/eid1908.121864 · Cited by 28
Environmental assessment reveals the presence of MLB‐1 human astrovirus in Uruguay
Lizasoain, A., Tort, L., García, M., Gómez, M. M., Leite, J. P. G., Miagostovich, M., Cristina, J., Colina, R., & Victoria, M. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12856 · Cited by 27 · see citing works
“Since 2009, several studies (Finkbeiner et al. 2009a,c; Kapoor et al. 2009) suggested the worldwide distribution of MLB-1 HAstV having been detected in different continents (Ahmed et al.”
BackgroundFirth, A., & Atkins, J. (2010) · Virology Journal · doi:10.1186/1743-422x-7-17 · Cited by 27 · see citing works
“[11] [12] [13] [14] for recent phylogenetic trees).”
Alternative cell lines to improve the rescue of infectious human astrovirus from a cDNA clone.
Velázquez-Moctezuma, R., Baños-Lara, M. D. R., Acevedo, Y., & Méndez, E. (2012) · Journal of Virological Methods · doi:10.1016/j.jviromet.2011.11.005 · Cited by 26 · see citing works
Moschidou, P., Martella, V., Lorusso, E., Desario, C., Pinto, P., Losurdo, M., Catella, C., Parisi, A., Bányai, K., & Buonavoglia, C. (2011) · Journal of Veterinary Diagnostic Investigation · doi:10.1177/1040638711404149 · Cited by 26
Unveiling Viruses Associated with Gastroenteritis Using a Metagenomics Approach
Fernandez-Cassi, X., Martínez-Puchol, S., Silva-Sales, M., Cornejo, T., Bartolomé, R., Bofill-Mas, S., & Girones, R. (2020) · Viruses · doi:10.3390/v12121432 · Cited by 25 · see citing works
“Recently, astroviruses have also been associated with a wider array of diseases, including central nervous system alterations such as meningitis or acute flaccid paralysis [57,58].”
BackgroundHigh prevalence of four novel astrovirus genotype species identified from rodents in China.
To, K., Chan, W., Li, K. S., Lam, C. S. F., Chen, Z.-W., Tse, H., Lau, S., Woo, P., & Yuen, K. Y. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000766 · Cited by 23
Molecular epidemiology of astrovirus in children with gastroenteritis in southwestern Nigeria
Arowolo, K. O., Ayolabi, C. I., Adeleye, I., Lapinski, B., Santos, J. S., & Raboni, S. M. (2020) · Archives of Virology · doi:10.1007/s00705-020-04741-0 · Cited by 22 · see citing works
The Viruses of the Gut Microbiota
Lecuit, M., & Éloit, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00021-5 · Cited by 26 · see citing works
“Parechovirus [36] Cardiovirus [37] Salivirus [38] Picobirnaviridae Picobirnavirus [16] Astroviridae Astrovirus [39] Reoviridae Rotavirus Caliciviridae Norovirus [40] Sapovirus [41] Adenoviridae Mastadenovirus C and F, and others [42] Anelloviridae Anellovirus [16] Cycloviridae Circovirus [43] Cyclovirus [43] Parvoviri…”
Structure of the divergent human astrovirus MLB capsid spike
Delgado-Cunningham, K., López, T., Khatib, F., Arias, C. F., & DuBois, R. M. (2022) · Structure · doi:10.1016/j.str.2022.10.010 · Cited by 21 · see citing works
Linsuwanon, P., Poovorawan, Y., Li, L., Deng, X., Vongpunsawad, S., & Delwart, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135573 · Cited by 21 · see citing works
“It is associated with gastroenteritis predominantly effecting young children [56].”
BackgroundSelf-citationHuman Astrovirus Infection in a Patient with New-Onset Celiac Disease
Smits, S., van Leeuwen, M., van der Eijk, A. A., Fraaij, P., Escher, J., Simon, J., & Osterhaus, A. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01164-10 · Cited by 21
“as described above, and a degenerate astrovirus PCR (14) (Fig.”
BackgroundResultInfluentialMi, S., Guo, S., Xing, C., Xiao, C., He, B., Wu, B., Xia, X., Tu, C., & Gong, W. (2020) · Journal of Virology · doi:10.1128/jvi.01513-20 · Cited by 20
Complete Genome of a Novel Porcine Astrovirus
Shan, T., Wang, C., Tong, W., Zheng, H., Hua, X.-G., Yang, S., Guo, Y.-F., Zhang, W., & Tong, G. (2012) · Journal of Virology · doi:10.1128/jvi.02598-12 · Cited by 20 · see citing works
“Recently, a group of novel astroviruses which were highly diverse was identified in humans and swine (3, 4, 8, 11, 14, 18).”
Background
- Authors
- Kapoor, A., Li, L., Victoria, J., Oderinde, B., Mason, C., Pandey, P., Zaidi, S. Z., & Delwart, E.
- Affiliations
- University of California, San Francisco (US)
- University of Maiduguri (NG)
- Armed Forces Research Institute of Medical Science (TH)
- CIWEC Clinic Travel Medicine Center, Kathmandu, Nepal
- National Institute of Health (PK)
- Venue
- Journal of General Virology
- Publisher
- Microbiology Society
- Published
- 2009-12-01
- Volume
- 90
- Issue
- 12
- Pages
- 2965-2972
- ISSN
- 0022-1317 (ISSN-L)
- 1465-2099
- PMC
- PMC2796194
- OpenAlex
- W2114025285
- Cited by
- 241
- References
- 33
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 13 · 2022: 6 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 17 · 2017: 17 · 2016: 17 · 2015: 17 · 2014: 14 · 2013: 22 · 2012: 23
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of General Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Blood Systems Research Institute
- National Heart, Lung, and Blood Institute (R01HL083254)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- human astrovirus, zoonotic transmission, viral emergence, viral genome, phylogenetic analysis, gastroenteritis
- MeSH terms
- Animals, Mamastrovirus, Diarrhea, Feces, Gastroenteritis, Humans, Molecular Sequence Data, Phylogeny, Species Specificity, Sequence Analysis, DNA, Astroviridae Infections
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