Antimicrobial resistance acquisition via natural transformation: context is everything

Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer

von Wintersdorff, C. J. H., Penders, J., van Niekerk, J. M., Mills, N. D., Majumder, S., van Alphen, L. B., Savelkoul, P. H. M., & Wolffs, P. F. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00173 · Cited by 1,707 · see citing works

The shared antibiotic resistome of soil bacteria and human pathogens

Forsberg, K. J., Reyes, A., Wang, B., Selleck, E. M., Sommer, M. O. A., & Dantas, G. (2012) · Science · doi:10.1126/science.1220761 · Cited by 1,650 · see citing works

Bacterial phylogeny structures soil resistomes across habitats

Forsberg, K. J., Patel, S., Gibson, M. K., Lauber, C. L., Knight, R. D., Fierer, N., & Dantas, G. A. (2014) · Nature · doi:10.1038/nature13377 · Cited by 1,291 · see citing works

Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens

Peterson, E., & Kaur, P. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02928 · Cited by 1,021 · see citing works

Bacterial transformation: distribution, shared mechanisms and divergent control

Johnston, C., Martin, B., Fichant, G. A., Polard, P., & Claverys, J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3199 · Cited by 737 · see citing works

Interconnected microbiomes and resistomes in low-income human habitats

Pehrsson, E. C., Tsukayama, P., Patel, S., Mejía-Bautista, M., Sosa-Soto, G., Navarrete, K. M., Calderon, M., Cabrera, L., Hoyos-Arango, W., Bertoli, M. T., et al. (2016) · Nature · doi:10.1038/nature17672 · Cited by 607 · see citing works

Highways of gene sharing in prokaryotes

Beiko, R. G., Harlow, T. J., & Ragan, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504068102 · Cited by 535 · see citing works

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme

Li, A., Figueroa, S., Jiang, T., Wu, P., Widelitz, R. B., Nie, Q. H., & Chuong, C. (2017) · Nature Communications · doi:10.1038/ncomms14139 · Cited by 463 · see citing works

Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniae

Prudhomme, M., Attaiech, L., Sanchez, G., Martin, B., & Claverys, J. (2006) · Science · doi:10.1126/science.1127912 · Cited by 455 · see citing works

Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum

Huttner, A. C., Harbarth, S., Carlet, J. M., Cosgrove, S. E., Goossens, H., Holmes, A. H., Jarlier, V., Voß, A., Pittet, D., & participants, F. T. W. H.-A. I. F. (2013) · Antimicrobial Resistance and Infection Control · doi:10.1186/2047-2994-2-31 · Cited by 451 · see citing works

Antiepileptic drug carbamazepine promotes horizontal transfer of plasmid-borne multi-antibiotic resistance genes within and across bacterial genera

Wang, Y., Lu, J., Mao, L., Li, J., Yuan, Z., Bond, P. L., & Guo, J. (2018) · The ISME Journal · doi:10.1038/s41396-018-0275-x · Cited by 443 · see citing works

Dissemination of antibiotic resistance genes from antibiotic producers to pathogens

Jiang, X., Ellabaan, M. M. H., Charusanti, P., Munck, C., Blin, K., Tong, Y., Weber, T., Sommer, M. O. A., & Lee, S. Y. (2017) · Nature Communications · doi:10.1038/ncomms15784 · Cited by 417 · see citing works

Chlorine disinfection promotes the exchange of antibiotic resistance genes across bacterial genera by natural transformation

Jin, M., Liu, L., Da-ning, W., Yang, D., Liu, W., Yin, J., Yang, Z.-W., Wang, H.-R., Qiu, Z., Shen, Z., et al. (2020) · The ISME Journal · doi:10.1038/s41396-020-0656-9 · Cited by 416 · see citing works

The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer

Borgeaud, S., Metzger, L. C., Scrignari, T., & Blokesch, M. (2015) · Science · doi:10.1126/science.1260064 · Cited by 391 · see citing works

Horizontal Transfer of the OXA-24 Carbapenemase Gene via Outer Membrane Vesicles: a New Mechanism of Dissemination of Carbapenem Resistance Genes in Acinetobacter baumannii

Rumbo, C., Fernández-Moreira, E., Merino, M., Poza, M., Mendez, J. A., Soares, N. C., Mosquera, A., Cháves, F., & Bou, G. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00929-10 · Cited by 353 · see citing works

Non-antibiotic pharmaceuticals enhance the transmission of exogenous antibiotic resistance genes through bacterial transformation

Wang, Y., Lu, J., Engelstädter, J., Zhang, S., Ding, P., Mao, L., Yuan, Z., Bond, P. L., & Guo, J. (2020) · The ISME Journal · doi:10.1038/s41396-020-0679-2 · Cited by 305 · see citing works

Integration of foreign DNA during natural transformation of Acinetobacter sp. by homology-facilitated illegitimate recombination

de Vries, J., & Wackernagel, W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042263399 · Cited by 221 · see citing works

Interspecies recombination between the penA genes of Neisseria meningitidis and commensal Neisseria species during the emergence of penicillin resistance in N. meningitidis: natural events and laboratory simulation

Bowler, L. D., Zhang, Q. Y., Riou, J. Y., & Spratt, B. G. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.2.333-337.1994 · Cited by 206 · see citing works

Barriers to Genetic Exchange between Bacterial Species: Streptococcus pneumoniae Transformation

Majewski, J., Zawadzki, P., Pickerill, P., Cohan, F. M., & Dowson, C. G. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.4.1016-1023.2000 · Cited by 205 · see citing works

Plasmids Spread Very Fast in Heterogeneous Bacterial Communities

Dionísio, F., Matić, I., Radman, M., Rodrigues, O. R., & Taddéi, F. (2002) · Genetics · doi:10.1093/genetics/162.4.1525 · Cited by 196 · see citing works

Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species

Domingues, S., Harms, K., Fricke, W. F., Johnsen, P. J., Silva, G., & Nielsen, K. M. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002837 · Cited by 195 · see citing works

Natural competence for transformation

Blokesch, M. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.058 · Cited by 176 · see citing works

Horizontal DNA Transfer Mechanisms of Bacteria as Weapons of Intragenomic Conflict

Croucher, N. J., Mostowy, R. J., Wymant, C., Turner, P., Bentley, S. D., & Fraser, C. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002394 · Cited by 160 · see citing works

Novel “Superspreader” Bacteriophages Promote Horizontal Gene Transfer by Transformation

Keen, E. C., Bliskovsky, V. V., Malagón, F., Baker, J. D., Prince, J. S., Klaus, J. S., & Adhya, S. L. (2017) · mBio · doi:10.1128/mbio.02115-16 · Cited by 153 · see citing works

Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation

Vilarrasa‐Blasi, R., Soler-Vila, P., Verdaguer-Dot, N., Russiñol, N., Stefano, M. D., Chapaprieta, V., Clot, G., Farabella, I., Cuscó, P., Kulis, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20849-y · Cited by 146 · see citing works

Inter-species population dynamics enhance microbial horizontal gene transfer and spread of antibiotic resistance

Cooper, R. M., Tsimring, L. S., & Hasty, J. (2017) · eLife · doi:10.7554/elife.25950 · Cited by 145 · see citing works

Triclosan at environmental concentrations can enhance the spread of extracellular antibiotic resistance genes through transformation

Lu, J., Wang, Y., Zhang, S., Bond, P. L., Yuan, Z., & Guo, J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.136621 · Cited by 124 · see citing works

Induction of competence for genetic transformation by antibiotics: convergent evolution of stress responses in distant bacterial species lacking SOS?

Charpentier, X., Polard, P., & Claverys, J. P. (2012) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.08.001 · Cited by 118 · see citing works

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria

Veening, J., & Blokesch, M. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.66 · Cited by 115 · see citing works

Water Disinfection Byproducts Increase Natural Transformation Rates of Environmental DNA in Acinetobacter baylyi ADP1

Mantilla‐Calderon, D., Plewa, M. J., Michoud, G., Fodelianakis, S., Daffonchio, D. G., & Hong, P. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b00692 · Cited by 108 · see citing works

Homologous recombination at the border: Insertion-deletions and the trapping of foreign DNA in Streptococcus pneumoniae

Prudhomme, M., Libante, V., & Claverys, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032262999 · Cited by 100 · see citing works

Natural genetic transformation of Pseudomonas stutzeri in a non-sterile soil

Sikorski, J., Graupner, S., Lorenz, M. G., & Wackernagel, W. (1998) · Microbiology · doi:10.1099/00221287-144-2-569 · Cited by 96 · see citing works

Double illegitimate recombination events integrate DNA segments through two different mechanisms during natural transformation of Acinetobacter baylyi

Hülter, N. F., & Wackernagel, W. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.06096.x · Cited by 90 · see citing works

In Vitro Exchange of Fluoroquinolone Resistance Determinants betweenStreptococcus pneumoniaeand Viridans Streptococci and Genomic Organization of theparE‐parCRegion inS. mitis

Janoir, C., Podglajen, I., Kitzis, M.-D., Poyart, C., & Gutmann, L. (1999) · The Journal of Infectious Diseases · doi:10.1086/314888 · Cited by 72 · see citing works

A globally distributed mobile genetic element inhibits natural transformation of Vibrio cholerae

Dalia, A. B., Seed, K. D., Calderwood, S. B., & Camilli, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509097112 · Cited by 67 · see citing works

Pseudomonas aeruginosa is capable of natural transformation in biofilms

Nolan, L. M., Turnbull, L., Katrib, M., Osvath, S. R., Losa, D., Lazenby, J., & Whitchurch, C. B. (2020) · Microbiology · doi:10.1099/mic.0.000956 · Cited by 61 · see citing works

In and out—contribution of natural transformation to the shuffling of large genomic regions

Blokesch, M. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.04.001 · Cited by 52 · see citing works

Natural Competence Is Common among Clinical Isolates of Veillonella parvula and Is Useful for Genetic Manipulation of This Key Member of the Oral Microbiome

Knapp, S. J., Brodal, C., Peterson, J., Qi, F., Kreth, J., & Merritt, J. L. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00139 · Cited by 51 · see citing works

Fluorescence-Based Detection of Natural Transformation in Drug-Resistant Acinetobacter baumannii

Godeux, A.-S., Lupo, A., Haenni, M., Guette-Marquet, S., Wilharm, G., Laaberki, M.-H., & Charpentier, X. (2018) · Journal of Bacteriology · doi:10.1128/jb.00181-18 · Cited by 51 · see citing works

ON THE SPECIFICITY OF THE DESOXYRIBONUCLEIC ACID WHICH INDUCES STREPTOMYCIN RESISTANCE IN HEMOPHILUS

Leidy, G., Hahn, E., & Alexander, H. E. (1956) · The Journal of Experimental Medicine · doi:10.1084/jem.104.3.305 · Cited by 50 · see citing works

Diverse conjugative elements silence natural transformation in Legionella species

Durieux, I., Ginévra, C., Attaiech, L., Picq, K., Juan, P.-A., Jarraud, S., & Charpentier, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909374116 · Cited by 49 · see citing works

Sexual Selection in Bacteria?

Vos, M., Buckling, A., & Kuijper, B. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.07.009 · Cited by 39 · see citing works

Plasmid Transfer via Transduction from Streptococcus thermophilus to Lactococcus lactis

Ammann, A., Neve, H., Geis, A., & Heller, K. J. (2008) · Journal of Bacteriology · doi:10.1128/jb.01448-07 · Cited by 35 · see citing works

Kin discrimination promotes horizontal gene transfer between unrelated strains in Bacillus subtilis

Stefanic, P., Belcijan, K., Kraigher, B., Kostanjšek, R., Nesme, J., Madsen, J. S., Kovac, J., Sørensen, S. J., Vos, M., & Mandic-Mulec, I. (2021) · Nature Communications · doi:10.1038/s41467-021-23685-w · Cited by 33 · see citing works

Prophage-Dependent Neighbor Predation Fosters Horizontal Gene Transfer by Natural Transformation

Molina-Quiroz, R. C., Dalia, T. N., Camilli, A., Dalia, A. B., & Silva-Valenzuela, C. A. (2020) · mSphere · doi:10.1128/msphere.00975-20 · Cited by 31 · see citing works

Sexual Isolation in Acinetobacter baylyi Is Locus-Specific and Varies 10,000-Fold Over the Genome

Ray, J. L., Harms, K., Wikmark, O.-G., Starikova, I., Johnsen, P. J., & Nielsen, K. M. (2009) · Genetics · doi:10.1534/genetics.109.103127 · Cited by 30 · see citing works

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain

Traglia, G. M., Place, K., Dotto, C., Fernandez, J. S., Montaña, S., Bahiense, C. D. S., Soler‐Bistué, A., Iriarte, A., Pérez, F., Tolmasky, M. E., et al. (2018) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2018.12.013 · Cited by 27 · see citing works

Effects of free antibiotic resistance genes in the environment on intestinal microecology of mice

Ding, C., Yang, D., Ma, J., Jin, M., Shen, Z., Shi, D., Tian, Z., Kang, M., Lǐ, J., & Qiu, Z. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111119 · Cited by 21 · see citing works

The evolution of bacterial pathogens in the Anthropocene

Vos, M. (2020) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2020.104611 · Cited by 19 · see citing works

Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates

Kothari, A., Soneja, D., Tang, A., Carlson, H. K., Deutschbauer, A. M., & Mukhopadhyay, A. (2019) · mSystems · doi:10.1128/msystems.00588-19 · Cited by 13 · see citing works

Tn1 transposition in the course of natural transformation enables horizontal antibiotic resistance spread in Acinetobacter baylyi

Kloos, J., Johnsen, P. J., & Harms, K. (2020) · Microbiology · doi:10.1099/mic.0.001003 · Cited by 12 · see citing works

Substitutions of short heterologous DNA segments of intragenomic or extragenomic origins produce clustered genomic polymorphisms

Harms, K., Lunnan, A., Hülter, N. F., Mourier, T., Vinner, L., Andam, C. P., Marttinen, P., Fridholm, H., Hansen, A. J., Hanage, W. P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615819114 · Cited by 9 · see citing works

Emerging issues in probiotic safety: 2023 perspectives

Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481 · see citing works

An Overview of the Recent Advances in Antimicrobial Resistance

Oliveira, M. T. D. S., Antunes, W., MOTA, S. R. F., Madureira-Carvalho, Á., Dinis‐Oliveira, R. J., & da Silva, D. D. (2024) · Microorganisms · doi:10.3390/microorganisms12091920 · Cited by 295 · see citing works

Mechanism of antibacterial resistance, strategies and next-generation antimicrobials to contain antimicrobial resistance: a review

Belay, W. Y., Getachew, M., Tegegne, B. A., Teffera, Z. H., Dagne, A., Zeleke, T. K., Abebe, R. B., Gedif, A. A., Fenta, A., Yirdaw, G., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1444781 · Cited by 278 · see citing works

The Spread of Antibiotic Resistance Genes In Vivo Model

Tao, S., Chen, H., Li, N., Wang, T., & Liang, W. (2022) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2022/3348695 · Cited by 206 · see citing works

Genetic compatibility and ecological connectivity drive the dissemination of antibiotic resistance genes

Lund, D., Parras-Moltó, M., Inda-Díaz, J. S., Ebmeyer, S., Larsson, D. G. J., Johnning, A., & Kristiansson, E. (2025) · Nature Communications · doi:10.1038/s41467-025-57825-3 · Cited by 90 · see citing works

Plasmid-mediated antibiotic resistance gene transfer under environmental stresses: Insights from laboratory-based studies

Li, L.-G., & Zhang, T. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.163870 · Cited by 72 · see citing works

Persistent Threats: A Comprehensive Review of Biofilm Formation, Control, and Economic Implications in Food Processing Environments

Ban-Cucerzan, A., Imre, K., Morar, A., Marcu, A., Hotea, I., Popa, S. A., Pătrînjan, R.-T., Bucur, I.-M., Gaspar, C. M., Plotuna, A.-M., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13081805 · Cited by 61 · see citing works

The Spread of Antibiotic Resistance Is Driven by Plasmids Among the Fastest Evolving and of Broadest Host Range

Coluzzi, C., & Rocha, E. P. C. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf060 · Cited by 56 · see citing works

Comprehensive insights into antibiotic resistance gene migration in microalgal-bacterial consortia: Mechanisms, factors, and perspectives

Li, S., Li, X., Chang, H., Zhong, N., Ren, N., & Ho, S. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166029 · Cited by 52 · see citing works

Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment

Klümper, U., Fang, P., Li, B., Xia, Y., Frigon, D., Hamilton, K. A., Quon, H., Berendonk, T. U., & Barrón, M. D. L. C. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-025-00154-8 · Cited by 52 · see citing works

Combating antimicrobial resistance: the silent war

Bo, L., Sun, H., Li, Y.-D., Zhu, J. J., Wurpel, J. N. D., Lin, H., & Chen, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1347750 · Cited by 50 · see citing works

The role of bacteriophages in facilitating the horizontal transfer of antibiotic resistance genes in municipal wastewater treatment plants

Wang, Q., Wang, M., Yang, Q., Feng, L., Zhang, H., Wang, R., & Wang, R. (2024) · Water Research · doi:10.1016/j.watres.2024.122776 · Cited by 48 · see citing works

Dominance of phage particles carrying antibiotic resistance genes in the viromes of retail food sources

Blanco‐Picazo, P., Morales-Cortés, S., Ramos‐Barbero, M. D., García‐Aljaro, C., Rodríguez‐Rubio, L., & Muniesa, M. (2022) · The ISME Journal · doi:10.1038/s41396-022-01338-0 · Cited by 43 · see citing works

Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes?

Stanton, I. C., Tipper, H. J., Chau, K., Klümper, U., Subirats, J., & Murray, A. K. (2022) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5498 · Cited by 42 · see citing works

Explaining the resistomes in a megacity's water supply catchment: Roles of microbial assembly-dominant taxa, niched environments and pathogenic bacteria

Wu, D., Zhao, J., Su, Y., Yang, M., Dolfing, J., Graham, D. W., Yang, K., & Xie, B. (2022) · Water Research · doi:10.1016/j.watres.2022.119359 · Cited by 39 · see citing works

Non-antibiotic compounds associated with humans and the environment can promote horizontal transfer of antimicrobial resistance genes

Alav, I., & Buckner, M. M. C. (2023) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2023.2233603 · Cited by 38 · see citing works

Deciphering the genetic network and programmed regulation of antimicrobial resistance in bacterial pathogens

Ramamurthy, T., Ghosh, A., Chowdhury, G., Mukhopadhyay, A. K., Dutta, S., & Miyoshi, S.-I. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.952491 · Cited by 35 · see citing works

Anthropogenic pollution may enhance natural transformation in water, favouring the spread of antibiotic resistance genes

Sivalingam, P., Sabatino, R., Sbaffi, T., Corno, G., Fontaneto, D., Borgomaneiro, G., Rogora, M., Crotti, E., Mapelli, F., Borin, S., et al. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134885 · Cited by 32 · see citing works

Chlorine disinfection modifies the microbiome, resistome and mobilome of hospital wastewater – A nanopore long-read metagenomic approach

Rolbiecki, D., Paukszto, Ł., Krawczyk, K., Korzeniewska, E., Sawicki, J., & Harnisz, M. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132298 · Cited by 30 · see citing works

Algae blooms with resistance in fresh water: Potential interplay between Microcystis and antibiotic resistance genes

Ji, W., Ma, J., Zheng, Z., Al‐Herrawy, A. Z., Xie, B., & Wu, D. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173528 · Cited by 23 · see citing works

Antibiotic residues and antibiotic resistance genes in African water systems: Implications for safe drinking water, aquatic ecosystems, and Sustainable Development Goals

Okeke, E. S., Nwankwo, C. E. I., Ezeorba, T. P. C., Ogugofor, M. O., & Nwuche, C. O. (2024) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2024.106636 · Cited by 22 · see citing works

Effective antibiotic dosing in the presence of resistant strains

Ali, A., Imran, M., Sial, S., & Khan, A. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0275762 · Cited by 21 · see citing works

Catch me if you can: capturing microbial community transformation by extracellular DNA using Hi-C sequencing

Calderón-Franco, D., van Loosdrecht, M. C. M., Abeel, T., & Weissbrodt, D. G. (2023) · Antonie van Leeuwenhoek · doi:10.1007/s10482-023-01834-z · Cited by 21 · see citing works

Evaluation of Efflux-Mediated Resistance and Biofilm formation in Virulent Pseudomonas aeruginosa Associated with Healthcare Infections

Akinduti, P. A., George, O. W., Ohore, H. U., Ariyo, O. E., Popoola, S. T., Adeleye, A. I., Akinwande, K., Popoola, J. O., Rotimi, S. O., Olufemi, F. O., et al. (2023) · Antibiotics · doi:10.3390/antibiotics12030626 · Cited by 22 · see citing works

Occurrence, fate and potential health risks of antibiotic resistomes in a constructed wetlands-reservoir ecosystem for drinking water source improvement

Li, X., Xie, J., Ding, C., Du, H., Gao, S.-H., Ma, W., Feng, L., Zhang, H., & Wang, A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.166055 · Cited by 19 · see citing works

Urban wastewater disinfection by iron chelates mediated solar photo-Fenton: Effects on seven pathogens and antibiotic resistance transfer potential

Manna, P. L., Carluccio, M. D., Oliva, G., Vigliottá, G., & Rizzo, L. (2023) · Water Research · doi:10.1016/j.watres.2023.120966 · Cited by 18 · see citing works

Visualizing dynamic competence pili and DNA capture throughout the long axis of Bacillus subtilis

Zuke, J. D., Erickson, R., Hummels, K. R., & Burton, B. M. (2023) · Journal of Bacteriology · doi:10.1128/jb.00156-23 · Cited by 15 · see citing works

Antimicrobial resistance with a focus on antibacterial, antifungal, antimalarial, and antiviral drugs resistance, its threat, global priority pathogens, prevention, and control strategies: a review

Belay, W. Y., Getachew, M., Tegegne, B. A., Teffera, Z. H., Dagne, A., Zeleke, T. K., Wondm, S. A., Abebe, R. B., Gedif, A. A., Fenta, A., et al. (2025) · Therapeutic Advances in Infectious Disease · doi:10.1177/20499361251340144 · Cited by 16 · see citing works

Based on whole genome sequencing and metabolomics analysis the safety and probiotic characteristics of Lacticaseibacillus paracasei 36 isolated from Chinese fermented vegetables

Wang, F., Li, X., Wang, Q., Jin, Q., Fu, A., Zhang, Q., Yang, R., Deng, B., & Li, W. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105405 · Cited by 14 · see citing works

Improved DNA binding to a type IV minor pilin increases natural transformation

Ellison, T. J., & Ellison, C. K. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf467 · Cited by 14 · see citing works

Environmental concentrations of surfactants as a trigger for climax of horizonal gene transfer of antibiotic resistance

Wang, X., Du, G., Qiao, Z., Yang, Y., Shi, H., Zhang, D., & Pan, X. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17034 · Cited by 14 · see citing works

Neglected contributors to the transmission of bacterial antibiotic resistance in drinking water: Extracellular antibiotic resistance genes and the natural transformation

Zhang, M., Liu, J., Zhang, W., Feng, M., Yu, X., & Ye, C. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175970 · Cited by 14 · see citing works

Nematodes Degrade Extracellular Antibiotic Resistance Genes by Secreting DNase II Encoded by the nuc-1 Gene

Dong, W., Liu, Y., Hou, J., Zhang, J., Xu, J., Yang, K., Zhu, L., & Lin, D. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c03829 · Cited by 13 · see citing works

Enterococci for human health: A friend or foe?

Wang, Y., Xu, W., Guo, S., Xu, S., Wang, J., Zhang, S., Kuang, Y., & Jin, P. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107381 · Cited by 14 · see citing works

A Broad‐Spectrum Horizontal Transfer Inhibitor Prevents Transmission of Plasmids Carrying Multiple Antibiotic Resistance Genes

Jia, Y., Zheng, Z., Yang, B., Zhang, H., Wang, Z., & Liu, Y. (2024) · Transboundary and Emerging Diseases · doi:10.1155/2024/7063673 · Cited by 11 · see citing works

Combined bisdemethoxycurcumin and potassium iodide-mediated antimicrobial photodynamic therapy

Damrongrungruang, T., Panutyothin, N., Kongjun, S., Thanabat, K., & Ratha, J. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17490 · Cited by 10 · see citing works

Comparative genomic analysis reveals the adaptive traits of Ralstonia spp. in aquatic environments

Liu, G., Mao, C., Li, Q., Huo, D., & Li, T. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1625651 · Cited by 10 · see citing works

Naturally competent bacteria and their genetic parasites—a battle for control over horizontal gene transfer?

Vesel, N., Stare, E., Štefanič, P., Floccari, V. A., Mandić-Mulec, I., & Dragoš, A. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf035 · Cited by 11 · see citing works

Combating antibiotic resistance in the human-impacted environment with carbon-based materials: Applications and challenges

Fu, Y., Wang, F., Xiang, L., Harindintwali, J. D., Elsner, M., Amelung, W., Küppers, S., Jiang, X., Virta, M., Sillanpää, M. E. T., et al. (2023) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2023.2267933 · Cited by 9 · see citing works

Antibiotic resistance response of activated sludge to sulfamethoxazole: insights from the intracellular and extracellular DNA fractions

Martínez-Quintela, M., Calderón-Franco, D., van Loosdrecht, M. C. M., Suárez, S., Omil, F., & Weissbrodt, D. G. (2024) · Environmental Science Water Research & Technology · doi:10.1039/d3ew00591g · Cited by 9 · see citing works

Molecular interplay between ComEC domains allows for selective degradation of the non-translocating strand during natural transformation

Stedman, M. J. M., Deselaers, S., Braus, S. A. G., Wang, D., Balaguer, M. G., Gossert, A. D., & Hospenthal, M. K. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf932 · Cited by 9 · see citing works

Breaking barriers in antimicrobial therapy: resistance mechanisms and novel antimicrobial strategies

Suruchi, Tiwari, M., Pal, D., Gupta, A. K., & Jain, S. K. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.108163 · Cited by 9 · see citing works

Mechanisms of Bacterial Resistance and Innovative Strategies to Overcome Antimicrobial Resistance

Dini, I. (2026) · Antibiotics · doi:10.3390/antibiotics15030319 · Cited by 10 · see citing works

Environmental and public health risks of antibiotic resistance gene pollution in poultry systems: Sustainability impact, transmission pathways, and mitigation strategies

Aminudin, M. H., Amalina, F., Hamid, M. R. A., Sulaiman, S., Azfa, N., & Razak, A. S. A. (2026) · The Microbe · doi:10.1016/j.microb.2026.100658 · Cited by 8 · see citing works

The ComRS-SigX Pathway Regulates Natural Transformation in Streptococcus ferus

Rued, B. E., & Federle, M. J. (2023) · Journal of Bacteriology · doi:10.1128/jb.00089-23 · Cited by 7 · see citing works

Testing for the fitness benefits of natural transformation during community-embedded evolution

Winter, M. R., Harms, K., Johnsen, P. J., Buckling, A. G. J., & Vos, M. (2023) · Microbiology · doi:10.1099/mic.0.001375 · Cited by 7 · see citing works

Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes

Williams, S. M., Raffl, S., Kienesberger, S., Ilangovan, A., Zechner, E. L., & Waksman, G. (2025) · Nature Communications · doi:10.1038/s41467-025-60116-6 · Cited by 6 · see citing works

Bacteriophages: Potential Candidates for the Dissemination of Antibiotic Resistance Genes in the Environment

Sher, S., Khan, H. A., Khan, Z., Siddique, M. S., Bukhari, D. A., & Rehman, A. (2025) · Targets · doi:10.3390/targets3030025 · Cited by 6 · see citing works

Impact of Natural Transformation on the Acquisition of Novel Genes in Bacteria

Mazzamurro, F., Touchon, M., Charpentier, X., & Rocha, E. P. C. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf192 · Cited by 6 · see citing works

DNA binding is rate-limiting for natural transformationPreprint

Ellison, T. J., & Ellison, C. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.06.597730 · Cited by 6 · see citing works

Plastic-mediated transformation: A new route to navigate plasmid-borne antibiotic resistance genes

Ferheen, I., Cimarelli, L., Marcheggiani, S., Klümper, U., & Spurio, R. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179125 · Cited by 5 · see citing works

Free-Living Protozoa as Important Drivers of Antimicrobial Resistance in Engineered Water Systems and Their Ecological Niches

Beknazarova, M., van den Akker, B., & Ashbolt, N. J. (2025) · ACS ES&T Water · doi:10.1021/acsestwater.5c00540 · Cited by 5 · see citing works

The environmental threat of macrolide resistance: mechanisms, dissemination pathways, and urgent mitigation strategies

Devi, A., Sharma, V. K., Shrivastav, D., & Singh, S. (2025) · Environmental Monitoring and Assessment · doi:10.1007/s10661-025-14786-w · Cited by 5 · see citing works

The ecology of horizontal gene transfer.

Etten, J. V., & Johnson, M. D. (2026) · Trends in Genetics · doi:10.1016/j.tig.2026.02.002 · Cited by 2 · see citing works

RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Luo, H., Yang, Z., Lei, T., Li, C., Zhou, Z., Wang, M., Zhu, D., Li, P., & Cheng, A. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172873 · Cited by 5 · see citing works

Jellyfish blooms—an overlooked hotspot and potential vector for the transmission of antimicrobial resistance in marine environments

Elena, A., Orel, N., Fang, P., Herndl, G. J., Berendonk, T. U., Tinta, T., & Klümper, U. (2025) · mSystems · doi:10.1128/msystems.01012-24 · Cited by 5 · see citing works

Analysis of antibiotic resistance genes in livestock manure and receiving environment reveals non-negligible risk from extracellular genes

Xin, R., Yang, F., Zeng, Y. J., Zhang, M., & Zhang, K. (2025) · Environmental Science Processes & Impacts · doi:10.1039/d4em00570h · Cited by 5 · see citing works

Beyond Adaptive Gene Transfers: A Primer on Horizontal Gene Transfer Across Scales

Etten, J. V., & Johnson, M. D. (2026) · Integrative and Comparative Biology · doi:10.1093/icb/icag125 · Cited by 4 · see citing works

Combating Aminoglycoside Resistance: From Structural and Functional Characterisation to Therapeutic Challenges with RKAAT

Otun, S., Graca, R., & Achilonu, I. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037278814231226104509 · Cited by 4 · see citing works

Poultry slaughterhouse wastewater as a driver of bacterial community shifts and the spread of antibiotic resistance genes in aquatic ecosystems

de Farias, B. O., Lopes, E. D. S., Pereira, B. C., Pimenta, R. L., Parente, C. E. T., Seldin, L., & Saggioro, E. M. (2025) · Environmental Monitoring and Assessment · doi:10.1007/s10661-025-14745-5 · Cited by 3 · see citing works

Reversible DNA condensation drives natural transformation

Santiago, J. I., Ahmed, I., Hahn, J., Rubino, A., Choi, H., Adami, G., Dubnau, D. A., Neiditch, M. B., & Mickolajczyk, K. J. (2026) · Nature Communications · doi:10.1038/s41467-026-70559-0 · Cited by 3 · see citing works

Comamonas resistens Co-Producing GES-5 and OXA-17 in Urban Wastewater as a Potential Novel Disseminator of Clinically Relevant β-Lactamases

Furlan, J. P. R., Bueno, G. C., Carmo, R. R. D. S., Silva, R. L. O., Barbosa, M. R. F., Sato, M. I. Z., Lincopán, N., & Schenkman, S. (2025) · Current Microbiology · doi:10.1007/s00284-025-04394-9 · Cited by 3 · see citing works

Restriction–methylation systems regulate transformation in Acinetobacter baumannii

Soler‐Bistué, A. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.07.009 · Cited by 3 · see citing works

A minireview on the bioinformatics analysis of mobile gene elements in microbiome research

Schwarzerová, J., Labanava, A., Rychlı́k, I., Varga, M. J., & Čejková, D. (2023) · Frontiers in Bacteriology · doi:10.3389/fbrio.2023.1275910 · Cited by 3 · see citing works

Pannonibacter anstelovis sp. nov. Isolated from Two Cases of Bloodstream Infections in Paediatric Patients

Castellana, S., Laurentiis, V. D., Bianco, A., Sambro, L. D., Grassi, M., Leonardis, F. D., Derobertis, A. M., Carlo, C. D., Sparapano, E., Mosca, A., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12040799 · Cited by 3 · see citing works

Golden Guardians: Advanced pH Sensors with Built‐in Antimicrobial Defense

Justo‐Tirado, M., Pérez‐Herráez, I., Dea‐Ayuela, M. A., Galiana, C., González‐García, J., Zaballos-Garcı́a, E., & Pérez‐Prieto, J. (2024) · Advanced Optical Materials · doi:10.1002/adom.202400472 · Cited by 2 · see citing works

Highly sensitive detection and quantification of dissolved free extracellular DNA using colloid adsorption and foam concentration

Tamai, S., Ogura, Y., Okuno, M., Nukazawa, K., & Suzuki, Y. (2023) · Environmental Science Water Research & Technology · doi:10.1039/d3ew00015j · Cited by 2 · see citing works

ComI inhibits transformation in Bacillus subtilis by selectively killing competent cells

Smith, D. R., Kearns, D. B., & Burton, B. M. (2024) · Journal of Bacteriology · doi:10.1128/jb.00413-23 · Cited by 2 · see citing works

Effect of chemotherapeutic agents on natural transformation frequency in Acinetobacter baylyi

Winter, M. R., Vos, M., Buckling, A. G. J., Johnsen, P. J., & Harms, K. (2024) · Access Microbiology · doi:10.1099/acmi.0.000733.v4 · Cited by 2 · see citing works

Selection for florfenicol resistance at sub-MIC concentrations in Pasteurella multocida

Hughes, A., Pelligand, L., Andersson, D. I., & Mead, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0327115 · Cited by 2 · see citing works

Viewing landfill-borne antibiotic resistance genes through the kaleidoscope of “One Health”: Essential legacies and research needs from the environmental dimension

Wu, D., Fang, R., & Xie, B. (2022) · Current Opinion in Environmental Science & Health · doi:10.1016/j.coesh.2022.100424 · Cited by 2 · see citing works

pH-gated activation of nematodes-secreted NUC-1 accelerates extracellular antibiotic resistance gene degradation in aquatic environments

Dong, W., Liu, Y., Lin, M., Zhang, J., & Lin, D. (2025) · Water Research · doi:10.1016/j.watres.2025.123788 · Cited by 1 · see citing works

BaeR and H-NS control CRISPR-Cas-mediated immunity and virulence in Acinetobacter baumannii

Yu, T., Xie, J. Y., Huang, X., Huang, J., Bao, G., Yuan, W., Gao, C., Liu, C., Hu, J., Yang, W., et al. (2025) · mSystems · doi:10.1128/msystems.01067-25 · Cited by 1 · see citing works

Chlorination level-dependent amplification of antibiotic resistance genes dissemination by chlorinated paraffins via ROS-mediated natural transformation

Wang, H., Dai, Q., Yin, Y., Wang, L., Li, C., Sheng, Q., Piao, Z. H., & Zhang, Y. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.140360 · Cited by 1 · see citing works

Innovative approaches to bacterial inactivation in marine fish aquaculture: strategies for vaccine and paraprobiotic development

Lal, M. T. M., WONG, Z. C., Amin, Z., Jaziri, A. A., Prihanto, A. A., Amin, A. A., & Yanuhar, U. (2025) · Journal of Microorganism Control · doi:10.4265/jmc.30.4_107 · Cited by 1 · see citing works

Antimicrobial resistance and the human gut microbiome—a food safety perspective

Diaz‐Amigo, C., Pino, L. E. B. D., Lejeune, J., Ferreira, J. P., & Bessy, C. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2629533 · Cited by 4 · see citing works

Advancing antimicrobial stewardship through the One Health Stewardship Competency Model for Nursing

Stubbs, M., Taylor, C., Renfrew, B., Prinsen, A., Towsey, J., Lethbridge, L., & Porteous, B. (2026) · Nurse Education Today · doi:10.1016/j.nedt.2026.107252 · Cited by 1 · see citing works

A recent update on the use of antimicrobials for animal health in Yogyakarta, Indonesia

Wijayanti, A. D., Rosetyadewi, A. W., Pratama, A., Septana, A. I., Setyawan, D. C. B., & Fitriana, I. (2023) · International Journal of One Health · doi:10.14202/ijoh.2023.67-73 · Cited by 1 · see citing works

Genetic transformation and cell division delay in competent Staphylococcus aureusPreprint

Morgene, F., Zeghlache, C. R., Feng, S. Y., Hauck, Y., & Mirouze, N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.29.498089 · Cited by 1 · see citing works

The ComRS-SigX pathway regulates natural transformation in Streptococcus ferusPreprint

Rued, B. E., & Federle, M. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.06.531454 · Cited by 1 · see citing works

Molecular interplay between ComEC domains leads to efficient DNA translocation during natural transformationPreprint

Stedman, M. J. M., Deselaers, S., Braus, S. A. G., Wang, D., Balaguer, M. G., Gossert, A. D., & Hospenthal, M. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.08.647572 · Cited by 1 · see citing works

DNA uptake and twitching motility are controlled by the small RNA Arp through repression of pilin translation in Acinetobacter baumanniiPreprint

Hamrock, F. J., Guest, T., Daum, M. N., Connell, O., Ershova, A. S., Hokamp, K., Fleming, A. B., Gebhardt, M. J., Westermann, A. J., & Kröger, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.19.665661 · Cited by 1 · see citing works

Antimicrobial Resistance in Goat Production Practices

Das, B., Mandal, K. D., Suthar, A. N., & Maji, C. (2023) · doi:10.1002/9781119896142.ch20

Natural transformation and cell division delay in competent Staphylococcus aureus

Morgene, F., Zeghlache, C. R., Feng, S. Y., Hauck, Y., & Mirouze, N. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02807-23

Perspective Chapter: One Health Approach Impact in Salmonella Public Health – Nexus with Molecular Mechanisms of Antimicrobial Resistance

Fadlalla, I. M. T. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1011603

Les amibes comme approche thérapeutique pour lutter contre les bactéries multirésistantes aux antibiotiques

Bornier, F. (2022) · theses.fr (ABES) · doi:10.70675/fdcfbe89zd1dfz4406z89b4zb6201ff5267d

High-resolution genomic analysis reveals abundant mosaic outcomes of bacterial natural transformation independent of MutS-mediated mismatch repair

Lombardino, J., Falbel, T. G., Dewey, C. N., & Burton, B. M. (2026) · mBio · doi:10.1128/mbio.00444-26

Dry–wet alternation enhances conjugative transfer of antibiotic resistance genes via redox and energy coupling

Zhang, J., Li, Y., Ma, Z., Wang, W., Li, H., & Wang, T. C. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.123668

Synthetic biology and genetic engineering for AMR management

Pazhamalai, V., Peddiraju, T., Romauld, S. I., & Meenambiga, S. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27781-8.10005-3

Soil to host environmental determinants fueling horizontal gene transfer and global AMR dissemination

Roy, M. K., Bhattacharjee, A., Borah, B., & Singh, A. K. (2026) · Folia Microbiologica · doi:10.1007/s12223-026-01545-8

Type VI secretion system completeness shapes evolutionary trade-offs in the Acinetobacter baumannii resistome

Zhang, M., Wang, S., Gao, J., Jie, J., Yu, Q., Li, D., Song, L., & Fan, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1867466

Structure and biochemistry reveal substrate-modulated ComEC nuclease activity during DNA processing

Deselaers, S., Wang, D., Cairoli, T., Afanasyev, P., & Hospenthal, M. K. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag861

Multilayered molecular mechanisms and regulatory networks of aminoglycoside resistance in Enterobacteriaceae

Lin, Y., Peng, L., Lv, S., Zheng, W., & Wang, Q. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1967050

Divergent fates of antibiotic resistance genes in free-living versus particle-attached bacteria: An EPS stoichiometric framework

Gao, Q., Lu, J., Hou, J., Ding, W., Xu, D., Zhou, C., & You, G. (2026) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2026.2741931

Dynamics of Antimicrobial Resistant Bacteria in Water Environments: Risks via Surface Waters and Combating Strategies

Kussia, G. G., Kassa, B. A., Amdiyee, A. A., Abate, T. A., & Tessema, T. S. (2026) · Environmental Microbiology · doi:10.1111/1462-2920.70451

[Mechanism and influencing factors of natural transformation in bacteria].

Ning, N., & Wang, H. (2018) · PubMed · doi:10.13345/j.cjb.180005 · Cited by 1 · see citing works

Context-Dependent Acquisition of Antimicrobial Resistance Mechanisms

(10645931), M. W. (2024) · Open Research Exeter (University of Exeter)

Various pathways leading to the acquisition of antibiotic resistance by natural transformation

Domingues, S., Nielsen, K. M., & Silva, G. (2012) · Mobile Genetic Elements · doi:10.4161/mge.23089 · Cited by 45 · see citing works

Detecting Natural Transformation of Acinetobacter Calcoaceticus, In Situ, Within Natural Epilithon Of The River Taff

Williams, H. G., Day, M. J., & Fry, J. C. (1992) · Springer eBooks · doi:10.1007/978-1-4613-0493-7_51 · Cited by 2 · see citing works

Large DNA fragment ISEc9-mediated transposition during natural transformation allows interspecies dissemination of antimicrobial resistance genes

Domingues, S., Lima, T., Escobar, C., Plantade, J., Charpentier, X., & Silva, G. (2025) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-025-05113-9 · Cited by 10 · see citing works