Cited by 23Fungal and yeast genetics researchPlant responses to elevated CO2Fungal Infections and Studies

Effects of CO2 in fungi

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Chadwick, Benjamin J, Lin, Xiaorong·2024·Current Opinion in Microbiology

Abstract

Carbon dioxide supplies carbon for photosynthetic species and is a major product of respiration for all life forms. Inside the human body where CO 2 is a by-product of the tricarboxylic acid cycle, its level reaches 5% or higher. In the ambient atmosphere, ∼.04% of the air is CO 2. Different organisms can tolerate different CO 2 levels to various degrees, and experiencing higher CO 2 is toxic and can lead to death. The fungal kingdom shows great variations in response to CO 2 that has been documented by different researchers at different time periods. This literature review aims to connect these studies, highlight mechanisms underlying tolerance to high levels of CO 2, and emphasize the effects of CO 2 on fungal metabolism and morphogenesis.

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Crossref · 10.1016/j.mib.2024.102488

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94 of 94 references verified0 citation errors · 0 not checkable

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  • Fungi sense CO2 by generating bicarbonate ions or directly through the type 2C-related protein phosphatase Ptc2, with a single orthologue B9J08_003504 in C. auris.

    “Fungi sense CO2 by generating bicarbonate ions28–30 or directly through the type 2C-related protein phosphatase Ptc231, with a single orthologue B9J08_003504 in C. auris32.”
  • Rca1 and Efg1 most likely engage carbonic anhydrase for responding to CO2-derived bicarbonate anions, supported by data showing that mutants lacking RCA1 and EFG1 exhibited hypersensitivity to acetazolamide, a specific Nce103 inhibitor.

    “Therefore, Rca1 and Efg1 most likely engage carbonic anhydrase for responding to CO2-derived bicarbonate anions30, which is supported by data showing that mutants lacking RCA1 and EFG1 exhibited hypersensitivity to acetazolamide, a specific Nce103 inhibitor (Extended Data Fig. 3d–f).”

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Authors
Chadwick, B. J., & Lin, X.
Affiliations
University of Georgia (US)
Corresponding author
Lin, Xiaorong
Venue
Current Opinion in Microbiology
Publisher
Elsevier BV
Published
2024-06
Volume
79
Pages
102488
ISSN
1369-5274 (ISSN-L)
OpenAlex
W4397017406
Cited by
23
References
96
Citations by year
2026: 9 · 2025: 11 · 2024: 3
FWCI
0.94
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Microbiology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • University of Georgia
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI147541)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant responses to elevated CO2
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
carbon dioxide, fungi, fungal metabolism, morphogenesis
MeSH terms
Carbon Dioxide, Fungi, Humans, Photosynthesis

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