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Cited by 18Antifungal resistance and susceptibilityFungal Infections and StudiesFungal and yeast genetics research

Innate immune response to Candida auris

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Holt, Ashley M, Nett, Jeniel E·2024·Current Opinion in Microbiology
DOI 10.1016/j.mib.2024.102510PMC PMC11323126
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Abstract

Candida auris, a newly emergent fungal species, has been spreading in health care systems and causing life-threatening infections. Intact innate immunity is essential for protection against many invasive fungal infections, including candidiasis. Here, we highlight recent studies exploring immune interactions with C. auris, including investigations using animal models and ex vivo immune cells. We summarize innate immune studies comparing C. auris and the common fungal pathogen Candida albicans. We also discuss how structures of the C. auris cell wall influence immune recognition, the role of soluble host factors in immune recognition, and areas of future study.

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  • Immune responses can control and eventually clear C. auris in immunocompetent hosts.

    “Immune responses can control and eventually clear C. auris in immunocompetent hosts.3,10”

    From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [10]

    The ‘Phagocyte responses to C. auris’ section says neutrophils help control infection in mice. It does not establish eventual clearance in immunocompetent hosts; the same section reports that C. auris can persist despite intact immunity. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Holt, A. M., & Nett, J. E.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Nett, Jeniel E
ORCID
Nett, Jeniel E
Venue
Current Opinion in Microbiology
Publisher
Elsevier BV
Published
2024-08
Volume
80
Pages
102510
ISSN
1369-5274 (ISSN-L)
DOI
10.1016/j.mib.2024.102510
PMC
PMC11323126
OpenAlex
W4400272573
Cited by
18
References
9
Citations by year
2026: 11 · 2025: 7
FWCI
1.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Microbiology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
Funders
NIH (R01AI145939, R21AI159583)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Candida auris, innate immunity, immune evasion, fungal cell wall, Candida albicans, candidiasis, neutrophils, macrophages, host-pathogen interaction, fungal recognition, emerging fungal pathogens
MeSH terms
Candida auris, Animals, Blood Proteins, Candida, Candida albicans, Candidiasis, Cell Wall, Humans, Immunity, Innate, Phagocytes, Host-Pathogen Interactions, Immune Evasion, Candidiasis, Invasive

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