Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections

Vila, Taissa; Montelongo-Jauregui, Daniel; Ahmed, Hussian; Puthran, Taanya; Sultan, Ahmed S.; Jabra-Rizk, Mary Ann

doi:10.1128/msphere.00760-20

Cited by 58Antifungal resistance and susceptibilityFungal Infections and StudiesYeasts and Rust Fungi Studies

Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections

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Vila, Taissa, Montelongo-Jauregui, Daniel, Ahmed, Hussian, Puthran, Taanya, Sultan, Ahmed S., Jabra-Rizk, Mary Ann·2020·mSphere

DOI 10.1128/msphere.00760-20PMC PMC7407074

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Abstract

The newly emerged Candida species C. auris has been associated with an exponential rise in invasive disease in health care facilities worldwide with a mortality rate approaching 60%. C. auris exhibits a high level of transmissibility, multidrug resistance, and persistence in hospital environments, yet little is known about its pathogenesis largely due to limited data from animal studies. We used clinically relevant murine models of infection to comparatively evaluate the host niche-specific pathogenic potential of C. auris and C. albicans . Findings demonstrated that C. auris adheres more avidly, forming robust biofilms on catheters implanted in mice. However, although C. auris adhered to oral tissue ex vivo , it failed to colonize the oral cavity in vivo . In contrast, in the intraperitoneal infection model, C. auris persisted longer in the peritoneal cavity and kidneys. Understanding the host-pathogen factors contributing to the rise of C. auris as a nosocomial pathogen is critical for controlling the spread of this species.

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C. auris persisted longer than C. albicans in kidneys of infected mice.
“In addition, C. auris persisted longer than C. albicans in kidneys of infected mice (26).”
From Differential skin immune responses in mice intradermally infected with Candida auris and Candida albicans (2023) · cites this paper as [26]
Candida auris has an extraordinary resistance profile to antifungals.
“One of the major phenotypic distinctions between other Candida species and C. auris is its extraordinary resistance profile to antifungals [5–7].”
From Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris (2024) · cites this paper as [6]

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Authors: Vila, T., Montelongo-Jauregui, D., Ahmed, H., Puthran, T., Sultan, A. S., & Jabra-Rizk, M. A.
Affiliations: University of Maryland, Baltimore (US)
Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, USA
ORCID: Vila, Taissa
Montelongo-Jauregui, Daniel
Sultan, Ahmed S.
Jabra-Rizk, Mary Ann
Venue: mSphere
Publisher: American Society for Microbiology
Published: 2020-08-26
Volume: 5
Issue: 4
ISSN: 2379-5042 (ISSN-L)
DOI: 10.1128/msphere.00760-20
PMC: PMC7407074
OpenAlex: W3047582300
Cited by: 58
References: 55
Citations by year: 2026: 15 · 2025: 13 · 2024: 10 · 2023: 11 · 2022: 3 · 2021: 6
FWCI: 0.66
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.asm.org/non-commercial-tdm-license (tdm)
Locations: mSphere (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: HHS | National Institutes of Health (R01AI130170)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: Candida auris, Candida albicans, fungal pathogenesis, mouse infection model, biofilm formation, catheter-related infection, oral colonization, peritoneal infection, kidney colonization, nosocomial fungal infections, host-pathogen interaction, multidrug resistance
MeSH terms: Animals, Candida, Candida albicans, Candidiasis, Disease Models, Animal, Female, Mice, Inbred C57BL, Phenotype, Virulence, Biofilms, Microscopy, Confocal, Microscopy, Electron, Transmission, Mice, Host-Pathogen Interactions

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Comparative Evaluations of the Pathogenesis of Candida auris Phenotypes and Candida albicans Using Clinically Relevant Murine Models of Infections

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