The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Candida albicans biofilms: development, regulation, and molecular mechanisms
Open accessAbstract
A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.
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“Biofilm formation helps fungal cells survive antifungal treatment by secreting extracellular matrix and enhancing drug efflux pump activity, which is closely related to antifungal tolerance and resistance [75–77].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [75]
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Bacterial biofilms: from the Natural environment to infectious diseases
Hall‐Stoodley, L., Costerton, J. W., & Stoodley, P. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro821 · Cited by 7,133
Microbial Biofilms: from Ecology to Molecular Genetics
Davey, M. E., & O’Toole, G. A. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.847-867.2000 · Cited by 3,184
MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
Chandra, J., Kuhn, D. M., Mukherjee, P. K., Hoyer, L. L., McCormick, T., & Ghannoum, M. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.18.5385-5394.2001 · Cited by 1,578
Mucins in the mucosal barrier to infection
Lindén, S. K., SUTTON, P. R. N., Karlsson, N. G., Korolik, V., & McGuckin, M. A. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.5 · Cited by 1,257
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
Naglik, J. R., Challacombe, S. J., & Hube, B. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.400-428.2003 · Cited by 1,179
Candida biofilms and their role in infection
Douglas, L. J. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00002-1 · Cited by 1,150
Candida albicans Biofilms and Human Disease
Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057
Self-citationCandida Infections of Medical Devices
Kojic, E. M., & Darouiche, R. O. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.2.255-267.2004 · Cited by 1,055
Andes, D. R., Safdar, N., Baddley, J. W., Playford, G., Reboli, A. C., Rex, J. H., Sobel, J. D., Pappas, P. G., Kullberg, B. J., & for the Mycoses Study Group (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis021 · Cited by 793
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Development and regulation of single- and multi-species Candida albicans biofilms
Lohse, M. B., Gulati, M., Johnson, A. D., & Nobile, C. J. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.107 · Cited by 643
Self-citationThe Female Vaginal Microbiome in Health and Bacterial Vaginosis
Chen, X. F., Lu, Y., Chen, T., & Li, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.631972 · Cited by 508
Biofilm of Candida albicans : formation, regulation and resistance
Pereira, R., Fontenelle, R. O. D. S., de Brito, É. H. S., & de Morais, S. M. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14949 · Cited by 417
Candida Species Biofilms’ Antifungal Resistance
Silva, S. M., Rodrigues, C. F., Araújo, D., Rodrigues, M. E., & Henriques, M. (2017) · Journal of Fungi · doi:10.3390/jof3010008 · Cited by 317
Virulence Factors in Candida species
Staniszewska, M. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190722152415 · Cited by 285
Metadata
- Authors
- Gulati, M., & Nobile, C. J.
- Affiliations
- University of California, Merced (US)
- Corresponding author
- Nobile, Clarissa J.
- ORCID
- Nobile, Clarissa J.
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 18
- Issue
- 5
- Pages
- 310-321
- ISSN
- 1286-4579 (ISSN-L)
- PMC
- PMC4860025
- OpenAlex
- W2252911663
- Cited by
- 738
- References
- 78
- Citations by year
- 2026: 77 · 2025: 100 · 2024: 101 · 2023: 99 · 2022: 104 · 2021: 81 · 2020: 74 · 2019: 35 · 2018: 31 · 2017: 28 · 2016: 8
- FWCI
- 5.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- NIH (R00AI100896)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida albicans, biofilm, biofilm formation, biofilm regulation, molecular mechanisms, antifungal resistance, host immune evasion, fungal virulence, biofilm-associated infections
- MeSH terms
- Candida albicans, Humans, Virulence, Gene Expression Regulation, Fungal, Biofilms
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