Cited by 738Antifungal resistance and susceptibilityFungal and yeast genetics researchBacterial biofilms and quorum sensing

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Candida albicans biofilms: development, regulation, and molecular mechanisms

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Gulati, Megha, Nobile, Clarissa J.·2016·Microbes and Infection

DOI 10.1016/j.micinf.2016.01.002PMC PMC4860025

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Abstract

A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.

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Authors: Gulati, M., & Nobile, C. J.
Affiliations: University of California, Merced (US)
Corresponding author: Nobile, Clarissa J.
ORCID: Nobile, Clarissa J.
Venue: Microbes and Infection
Publisher: Elsevier BV
Published: 2016-05
Volume: 18
Issue: 5
Pages: 310-321
ISSN: 1286-4579 (ISSN-L)
DOI: 10.1016/j.micinf.2016.01.002
PMC: PMC4860025
OpenAlex: W2252911663
Cited by: 738
References: 78
Citations by year: 2026: 77 · 2025: 100 · 2024: 101 · 2023: 99 · 2022: 104 · 2021: 81 · 2020: 74 · 2019: 35 · 2018: 31 · 2017: 28 · 2016: 8
FWCI: 5.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Microbes and Infection (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH (R00AI100896)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: Candida albicans, biofilm, biofilm formation, biofilm regulation, molecular mechanisms, antifungal resistance, host immune evasion, fungal virulence, biofilm-associated infections
MeSH terms: Candida albicans, Humans, Virulence, Gene Expression Regulation, Fungal, Biofilms

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Candida albicans biofilms: development, regulation, and molecular mechanisms

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