Candida albicans Biofilm Development and Its Genetic Control
Open accessAbstract
The fungus Candida albicans is a major source of device-associated infection because of its capacity for biofilm formation. It is part of the natural mucosal flora and thus has access to available niches that can lead to infection. In this chapter we discuss the major properties of C. albicans biofilms and the insight that has been gleaned from their genetic determinants. Our specific areas of focus include biofilm structure and development, cell morphology and biofilm formation, biofilm-associated gene expression, the cell surface and adherence, the extracellular matrix, biofilm metabolism, and biofilm drug resistance.
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The type of resistance and virulence of Candida in response to conventional VVC treatment is mainly dependent on the formation of the fungal biofilm.
“The type of resistance and virulence of Candida in response to conventional VVC treatment is mainly dependent on the formation of the fungal biofilm.”
From Treatment of Vulvovaginal Candidiasis—An Overview of Guidelines and the Latest Treatment Methods (2023) · cites this paper as [52]
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- Authors
- Desai, J. V., & Mitchell, A. P.
- Affiliations
- Carnegie Mellon University (US)
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2015-06-18
- Volume
- 3
- Issue
- 3
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC4507287
- OpenAlex
- W1133921326
- Cited by
- 94
- References
- 19
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 1
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology Spectrum (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI067703)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- Candida albicans, biofilm formation, biofilm structure, cell morphology, extracellular matrix, biofilm metabolism, drug resistance, device-related infection
- MeSH terms
- Antifungal Agents, Candida albicans, Cell Adhesion, Cell Wall, Equipment Contamination, Extracellular Matrix, Humans, Gene Expression, Biofilms, Drug Resistance, Fungal
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