Oral pathogenesis of Aggregatibacter actinomycetemcomitans

Gholizadeh, Pourya; Pormohammad, Ali; Eslami, Hosein; Shokouhi, Behrooz; Fakhrzadeh, Vahid; Kafil, Hossein Samadi

doi:10.1016/j.micpath.2017.11.001

Cited by 144Oral microbiology and periodontitis researchPeriodontal Regeneration and TreatmentsMicrobial infections and disease research

Oral pathogenesis of Aggregatibacter actinomycetemcomitans

Gholizadeh, Pourya, Pormohammad, Ali, Eslami, Hosein, Shokouhi, Behrooz, Fakhrzadeh, Vahid, Kafil, Hossein Samadi·2017·Microbial Pathogenesis

DOI 10.1016/j.micpath.2017.11.001

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Abstract

Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is a Gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localized aggressive periodontitis (LAP) and. consequently. bone resorption. The potential virulence factors of this organism are powerful leukotoxin, lipopolysaccharide (LPS), cell surface-associated materials, enzymes, and less well-defined virulence factors that will modulate the activity of the host defenses. This organism can induce bone resorption by various virulence factors in periodontal disease. In this review article, we reviewed the pathogenic roles of A. actinomycetemcomitans in periodontal disease and the mechanism which can induce bone resorption. Findings from several studies indicate that the interaction between virulence factors and the host immune system's response often progress bone resorption in periodontal disease. In this organism, GroEL, DnaK, HtpG, LTX, CDT, LPS, and cell surface-associated materials produce cytokines when exposed to the immune system. The produced cytokines are the main cause of tissue destruction and bone resorption in A. actinomycetemcomitans inflammation in periodontal disease.

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Fusobacterium nucleatum and A actinomycetemcomitans are well recognized in periodontal disease, and F nucleatum is noted for its role in the development of anaerobic microenvironments that facilitate the outgrowth of anaerobic periodontal pathogens.
“Fusobacterium nucleatum and A actinomycetemcomitans are well recognized in periodontal disease,220, 221 and F nucleatum is noted for its role in the development of anaerobic microenvironments that facilitate the outgrowth of anaerobic periodontal pathogens.222”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [221]

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Løkensgard, I. (1994) · FEMS Immunology & Medical Microbiology · doi:10.1016/0928-8244(94)00007-7 · Cited by 14 · see citing works
Antigenic cross‐reactivity and sequence homology between Actinobacillus actinomycetemcomitans GroEL protein and human fibronectin
Yoshioka, M., Grenier, D., Hinode, D., Fukui, M., & Mayrand, D. (2004) · Oral Microbiology and Immunology · doi:10.1111/j.0902-0055.2003.00125.x · Cited by 12 · see citing works
IL12, IL10, IFNγ and TNFα Expression in Human Primary Monocytes Stimulated with Bacterial Heat Shock GroEL (Hsp64) Protein
Nalbant, A., & Saygılı, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154085 · Cited by 9 · see citing works
Bacterial Heat Shock Protein GroEL (Hsp64) Exerts Immunoregulatory Effects on T Cells by Utilizing Apoptosis
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Expression of GroEL and DnaK Proteins during the Acquisition of a Transitory Resistance to Lethal Stresses byActinobacillus actinomycetemcomitans
Goulhen, F., Grenier, D., & Mayrand, D. (2003) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v15i2-3.7968 · Cited by 4 · see citing works
Lipopolysaccharide derived from Aggregatibacter actinomycetemcomitans inhibits differentiation of osteoblasts
Tachikake, M., Suzuki, J., Wang, Y., Mitsuhata, C., & Kozai, K. (2014) · Pediatric Dental Journal · doi:10.1016/j.pdj.2014.03.004 · Cited by 3 · see citing works
Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines
Jelaska (2000) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200010)43:10 · Cited by 2 · see citing works
Expression of GroEL and DnaK Proteins during the Acquisition of a Transitory Resistance to Lethal Stresses byActinobacillus actinomycetemcomitans
Goulhen, F., Grenier, D., & Mayrand, D. (2003) · Microbial Ecology in Health and Disease · doi:10.1080/08910600310016799 · Cited by 1 · see citing works

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Sorted by citations

The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens
Zhu, B., Macleod, L. C., Kitten, T. O., & Xu, P. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0043 · Cited by 228 · see citing works
“Aggregatibacter actinomycetemcomitans is another well-studied pathogen associated with periodontal diseases such as localized aggressive periodontitis and, consequently, bone resorption [167,168].”
Background
Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic
Cui, Z., Wang, P., & Gao, W. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1517154 · Cited by 154 · see citing works
“Aggregatibacter actinomycetemcomitans is a Gram-negative facultative anaerobic bacillus, which is primarily found in the late stages of periodontitis or localized aggressive periodontitis (LAP) (Gholizadeh et al., 2017).”
Periodontitis: etiology, conventional treatments, and emerging bacteriophage and predatory bacteria therapies
Łasica, A. M., Golec, P., Laskus‐Perendyk, A., Zalewska, M., Gędaj, M., & Popowska, M. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1469414 · Cited by 166 · see citing works
Anti-virulence therapeutic strategies against bacterial infections: recent advances
Dehbanipour, R., & Ghalavand, Z. (2022) · GERMS · doi:10.18683/germs.2022.1328 · Cited by 144 · see citing works
New Clinical Applications of Electrolyzed Water: A Review
Yan, P., Daliri, E. B., & Oh, D. (2021) · Microorganisms · doi:10.3390/microorganisms9010136 · Cited by 121 · see citing works
Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease
Gholizadeh, P., Mahallei, M., Pormohammad, A., Varshochi, M., Ganbarov, K., Zeinalzadeh, E., Yousefi, B., Bastami, M., Tanomand, A., Mahmood, S. S., et al. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.11.031 · Cited by 114 · see citing works
Self-citation
Linking mechanisms of periodontitis to Alzheimer's disease
Sadrameli, M., Bathini, P., & Alberi, L. A. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000797 · Cited by 90 · see citing works
Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease
Gu, Y., & Han, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093329 · Cited by 85 · see citing works
Current Advances in DNA Methylation Analysis Methods
Khodadadi, E., Fahmideh, L., Khodadadi, E., Dao, S., Yousefi, M., Taghizadeh, S., Asgharzadeh, M., Yousefi, B., & Kafil, H. S. (2021) · BioMed Research International · doi:10.1155/2021/8827516 · Cited by 76 · see citing works
“Although the treatment with bisulfite is widely used to detect 5-methyl cytosine from other cytosines, it involves some issues such as incomplete conversion, false-positive results, and difficult and time-consuming use [44, 47].”
BackgroundSelf-citation
Portable nanopore-sequencing technology: Trends in development and applications
Pin, C., Sun, Z., Wang, J., Liu, X., Bai, Y., Chen, J., Liu, A., Qiao, F., Chen, Y., Yuan, C., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1043967 · Cited by 73 · see citing works
“The use of bisulfite for the detection of 5-methyl cytosine, although widely used, does have certain limitations, including incomplete conversion, false-positive results, and difficulty in using (Laird et al., 2016; Gholizadeh et al., 2017).”
Background
Tools of Aggregatibacter actinomycetemcomitans to Evade the Host Response
Oscarsson, J., Claesson, R., Lindholm, M., Åberg, C. H., & Johansson, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8071079 · Cited by 62 · see citing works
“actinomycetemcomitans can be linked to the pathogenesis of periodontal disease [99].”
Background
Oral spirochetes: Pathogenic mechanisms in periodontal disease
Yousefi, L., Leylabadlo, H. E., Pourlak, T., Eslami, H., Taghizadeh, S., Ganbarov, K., Yousefi, M., Tanomand, A., Yousefi, B., & Kafil, H. S. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104193 · Cited by 52 · see citing works
Self-citation
The role of Akkermansia muciniphila in colorectal cancer: A double-edged sword of treatment or disease progression?
Faghfuri, E., & Gholizadeh, P. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116416 · Cited by 52 · see citing works
Self-citation
MALDI-TOF Mass Spectroscopy Applications in Clinical Microbiology
Alizadeh, M., Yousefi, L., Pakdel, F., Ghotaslou, R., Rezaee, M. A., Khodadadi, E., Oskouee, M. A., Barhaghi, M. H. S., & Kafil, H. S. (2021) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2021/9928238 · Cited by 48 · see citing works
“Bacterial pathogens are among the factors that threaten global health and can grow in humans [1], animals [2], and plants [3] and cause disease in their hosts under certain conditions, including the acquisition of virulence factors [4, 5].”
BackgroundSelf-citation
Adhesion, anti-adhesion and aggregation properties relating to surface charges of selected Lactobacillus strains: study in Caco-2 and H357 cells
Sophatha, B., Piwat, S., & Teanpaisan, R. (2020) · Archives of Microbiology · doi:10.1007/s00203-020-01846-7 · Cited by 46 · see citing works
Associations of the gut microbiome with hepatic adiposity in the Multiethnic Cohort Adiposity Phenotype Study
Hullar, M. A. J., Jenkins, I., Randolph, T. W., Curtis, K. R., Monroe, K. R., Ernst, T. M., Shepherd, J., Stram, D. O., Cheng, I. C., Kristal, B. S., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1965463 · Cited by 45 · see citing works
Oral Microbiome and Alzheimer’s Disease
Wan, J., & Fan, H. (2023) · Microorganisms · doi:10.3390/microorganisms11102550 · Cited by 45 · see citing works
“This bacterium is further clas-siﬁed into ﬁve serotypes (a-e) [38].”
Background
IL ‐22–expressing CD 4+AhR+ T lymphocytes are associated with RANKL ‐mediated alveolar bone resorption during experimental periodontitis
Monasterio, G., Budini, V., Fernández, B., Castillo, F. A., Rojas, C., Álvarez, C., Cafferata, E. A., Vicencio, E., Cortés, B. I., Cortéz, C., et al. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12654 · Cited by 45 · see citing works
Oral Pathogens’ Substantial Burden on Cancer, Cardiovascular Diseases, Alzheimer’s, Diabetes, and Other Systemic Diseases: A Public Health Crisis—A Comprehensive Review
Murray, P. E., Coffman, J. A., & Garcı́a-Godoy, F. (2024) · Pathogens · doi:10.3390/pathogens13121084 · Cited by 44 · see citing works
“Commonly prescribed antibiotics for response, the host cells release cytokines, growth factors, and acute phase proteins to a tt empt to repair damage to tissues and organs [70,78,142,157].”
Alveolar bone resorption and Th1/Th17‐associated immune response triggered during Aggregatibacter actinomycetemcomitans‐induced experimental periodontitis are serotype‐dependent
Monasterio, G., Castillo, F. A., Ibarra, J. P., Guevara, J., Rojas, L., Álvarez, C., Fernández, B., Agüero, A., Betancur, D., & Vernal, R. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0563 · Cited by 39 · see citing works
Effective Modalities of Periodontitis Induction in Rat Model
Khuda, F., Baharin, B., Anuar, N. N. M., Satimin, B. S. F., & Nasruddin, N. S. (2023) · Journal of Veterinary Dentistry · doi:10.1177/08987564231178459 · Cited by 37 · see citing works
Gut Microbiota and Human Body Interactions; Its Impact on Health: A Review
Hajiagha, M. N., Taghizadeh, S., Asgharzadeh, M., Dao, S., Ganbarov, K., Köse, Ş., & Kafil, H. S. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210104115836 · Cited by 35 · see citing works
Self-citation
Oral microbiota and periodontitis severity among Hispanic adults
Ortiz, A. P., Acosta-Pagán, K. T., Oramas-Sepúlveda, C., Castañeda‐Avila, M. A., Vilanova-Cuevas, B., Ramos‐Cartagena, J. M., Vivaldi, J., Pérez‐Santiago, J., Pérez, C. M., & Godoy‐Vitorino, F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.965159 · Cited by 34 · see citing works
Aggregatibacter actinomycetemcomitans and Filifactor alocis: Two exotoxin-producing oral pathogens
Ozuna, H., Snider, I., Belibasakis, G. N., Oscarsson, J., Johansson, A., & Uriarte, S. M. (2022) · Frontiers in Oral Health · doi:10.3389/froh.2022.981343 · Cited by 33 · see citing works
Wheat germ agglutinin liposomes with surface grafted cyclodextrins as bioadhesive dual-drug delivery nanocarriers to treat oral cells
Wijetunge, S. S., Wen, J., Yeh, C., & Sun, Y. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110572 · Cited by 33 · see citing works
Periodontal pathogens and cancer development
Zhou, Y., Meyle, J., & Groeger, S. E. (2024) · Periodontology 2000 · doi:10.1111/prd.12590 · Cited by 28 · see citing works
“158 163 Monocytes/macrophages exhibit high susceptibility to LtxA, resulting in their lysis through the activa - tion of caspase 1 and the secretion of IL-1 β .”
The virulence factor GroEL directs the osteogenic and adipogenic differentiation of human periodontal ligament stem cells through the involvement of JNK/MAPK and NF‐κB signaling
Zhang, L., Cheng, L., Cui, Y., Wu, Z., Cai, L., Liu, Y., Duan, M., Zhang, D., Zhou, C., & Xie, J. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0869 · Cited by 28 · see citing works
Point-of-care diagnostic devices for periodontitis – current trends and urgent need
Griffith, A., Chande, C., Kulkarni, S., Morel, J., Cheng, Y., Shimizu, E., Cugini, C., Basuray, S., & Kumar, V. (2024) · Sensors & Diagnostics · doi:10.1039/d3sd00317e · Cited by 27 · see citing works
Detection rates of periodontal bacteria and herpesviruses in different forms of periodontal disease
Puletić, M., Popović, B., Jankovic, S., & Brajović, G. (2020) · Microbiology and Immunology · doi:10.1111/1348-0421.12857 · Cited by 27 · see citing works
“actinomycetemcomitans is a Gram‐ negative, facultative anaerobic bacterium that possesses very potent virulent factors that modulate the activity of the host response and cause extensive alveolar bone resorption.(21,22) For a long time, it was associated with localized aggressive periodontitis, but it has been reporte…”
Background
Biofilms and oral health: nanotechnology for biofilm control
Govindarajan, D. K., Mohanarangam, M., Kadirvelu, L., Sivaramalingam, S. S., Jothivel, D., Ravichandran, A., Periasamy, S., & Kandaswamy, K. (2025) · Discover Nano · doi:10.1186/s11671-025-04299-3 · Cited by 27 · see citing works
Inhibitory Effects of Antimicrobial Photodynamic Therapy with Curcumin on Biofilm-Associated Gene Expression Profile of Aggregatibacter actinomycetemcomitans.
Pourhajibagher, M., Chiniforush, N., Monzavi, A., Barikani, H., Monzavi, M. M., Sobhani, S., Shahabi, S., & Bahador, A. (2018) · Europe PMC (PubMed Central) · Cited by 26 · see citing works
The Hunger Games: Aggregatibacter actinomycetemcomitans Exploits Human Neutrophils As an Epinephrine Source for Survival
Ozuna, H., Uriarte, S. M., & Demuth, D. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707096 · Cited by 26 · see citing works
Systemic immune response against the oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans is associated with the formation and rupture of intracranial aneurysms
Hallikainen, J., Pyysalo, M. J., Keränen, S., Kellokoski, J. K., Koivisto, T., Suominen, A. L., Pussinen, P. J., Pessi, T., & Frösén, J. (2021) · European Journal of Neurology · doi:10.1111/ene.14986 · Cited by 24 · see citing works
“actinomycetemcomitans, on the other hand, is linked to aggressive periodontitis, especially in the younger population [22].”
Background
Oral Pathogenic Bacteria and the Oral–Gut–Liver Axis: A New Understanding of Chronic Liver Diseases
Lei, Y., Li, S., He, M., Ao, Z., Wang, J., Wu, Q., & Wang, Q. (2023) · Diagnostics · doi:10.3390/diagnostics13213324 · Cited by 23 · see citing works
Weissella cibaria CMU exerts an anti‑inflammatory effect by inhibiting Aggregatibacter actinomycetemcomitans‑induced NF‑κB activation in macrophages
Kim, M., You, Y., Kang, J., Kim, H., & Kang, M. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11512 · Cited by 22 · see citing works
“actino‐ mycetemcomitans, a facultative anaerobic, gram‐negative, rod‐shaped bacterium, is a major causative agent of localized aggressive periodontitis (7,8).”
Background
Antibacterial activity, cytocompatibility, and thermomechanical stability of Ti40Zr10Cu36Pd14 bulk metallic glass
Rezvan, A., Sharifikolouei, E., Lassnig, A., Soprunyuk, V., Gammer, C., Spieckermann, F., Schranz, W., Najmi, Z., Cochis, A., Scalia, A. C., et al. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100378 · Cited by 22 · see citing works
The Oral Microbial Ecosystem in Age-Related Xerostomia: A Critical Review
Pei, X.-M., Zhou, L.-X., Tsang, M., Tai, W., & Wong, S. C. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312815 · Cited by 26 · see citing works
Dysregulation of lncRNA in Helicobacter pylori‐Infected Gastric Cancer Cells
Yousefi, L., Osquee, H. O., Ghotaslou, R., Rezaee, M. A., Pirzadeh, T., Sadeghi, J., Hemmati, F., Yousefi, B., Moaddab, S. Y., Yousefi, M., et al. (2021) · BioMed Research International · doi:10.1155/2021/6911734 · Cited by 20 · see citing works
Self-citation
Lactobacilli Attenuate the Effect of Aggregatibacter actinomycetemcomitans Infection in Gingival Epithelial Cells
Bueno, M. R., Ishikawa, K., Santos, G. D. A., Ando‐Suguimoto, E. S., Shimabukuro, N., Kawamoto, D., & Mayer, M. P. A. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.846192 · Cited by 20 · see citing works
Colorimetric detection of oral bacteria using functionalized gold nanoparticles as a plasmonic biosensor array
Wenck, C., Leopoldt, D., Habib, M., Hegermann, J., Stiesch, M., Doll‐Nikutta, K., Heisterkamp, A., & Torres‐Mapa, M. L. (2024) · Nanoscale Advances · doi:10.1039/d3na00477e · Cited by 20 · see citing works
“12 Aac is considered one of the main causes of endocarditis, so  tissue infections, abscess formation and periodontitis.”
Role and mechanism of the nod-like receptor family pyrin domain-containing 3 inflammasome in oral disease
Lv, K., Wang, G., Shen, C., Zhang, X., & Yao, H. (2018) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2018.10.003 · Cited by 19 · see citing works
Gingiva-derived Mesenchymal Stem Cells and Their Potential Applications in Oral and Maxillofacial Diseases
Cao, Z., & Gao, X. (2019) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x14666191107100311 · Cited by 18 · see citing works
The role of microbiota on rheumatoid arthritis onset
Juárez‐Chairez, M. F., Cid‐Gallegos, M. S., Jiménez‐Martínez, C., Prieto‐Contreras, L. F., & Bollain-y-Goytia, J. J. (2024) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.15122 · Cited by 17 · see citing works
Identification & correlation of bacterial diversity in oral cancer and long-term tobacco chewers- A case-control pilot study.
Sawant, S., Dugad, J., Parikh, D., Srinivasan, S., & Singh, H. (2021) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001417 · Cited by 13 · see citing works
High-Potential surface on zirconia ceramics for bacteriostasis and biocompatibility
Liu, K., Wang, G., Guo, S., Liu, J., Qu, W., Liu, N., Wang, H., Ji, J., Chu, P. K.-H., Gu, B., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111074 · Cited by 16 · see citing works
Human Microbiota in Esophageal Adenocarcinoma: Pathogenesis, Diagnosis, Prognosis and Therapeutic Implications
Dan, W., Peng, L., Yan, B., Li, Z., & Pan, F. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.791274 · Cited by 16 · see citing works
“It is now well accepted that both Tannerella forsythia and Aggregatibacter actinomycetemcomitans are Gram-negative periodontal pathogens that might contribute to the pathogenesis of periodontitis (Sharma, 2010; Gholizadeh et al., 2017).”
Background
The efficacy of diode laser and subgingival air polishing with erythritol in treatment of periodontitis (clinical and microbiological study)
Elmeligy, S. M. A., Saleh, W., Elewa, G. M., El-ezz, H. A., Mahmoud, N., & Elmeadawy, S. H. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04481-6 · Cited by 15 · see citing works
Probiotics, Prebiotics, Synbiotics, Postbiotics, and Bioactive Agents in Modulating Harmful Oral Biofilms
Ghamari, M., Sabzi, S., Rajabi, E., Khodadadi, G., Navidifar, T., Sadeghi, Z., & Bostanghadiri, N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10636-w · Cited by 16 · see citing works
GroEL triggers NLRP3 inflammasome activation through <?A3B2 pi6?>the TLR/NF-κB p-p65 axis in human periodontal <?A3B2 pi6?>ligament stem cells
Zhang, L., Duan, M., Pu, X., Zheng, H., Ning, X., Tu, Y., Xu, C., Zhang, D., Liu, C., & Xie, J. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024050 · Cited by 14 · see citing works
Lactobacillus lysates protect oral epithelial cells from pathogen-associated damage, increase secretion of pro-inflammatory cytokines and enhance barrier integrity
Mercer, S. D., Doherty, C., Singh, G., Willmott, T., Cheesapcharoen, T., Teanpaisan, R., O’Neill, C. A., Ledder, R. G., & McBain, A. J. (2025) · Scientific Reports · doi:10.1038/s41598-025-86914-y · Cited by 14 · see citing works
“This was especially notable for AA, which showed strong extracellular protein expression despite having a low CFU/mL count, demonstrating its tendency to form biofilms 35 .”
Characterization of Diverse Anelloviruses, Cressdnaviruses, and Bacteriophages in the Human Oral DNA Virome from North Carolina (USA)
Paietta, E. N., Kraberger, S. J., Custer, J. M., Vargas, K. L., Espy, C., Ehmke, E. E., Yoder, A. D., & Varsani, A. (2023) · Viruses · doi:10.3390/v15091821 · Cited by 12 · see citing works
“One of the main virulence factors of bacteria within Aggregatibacter is a leukotoxin capable of causing extensive damage to human immune tissues [91].”
Background
JP2 Genotype of Aggregatibacter actinomycetemcomitans in Caucasian Patients: A Presentation of Two Cases
Stähli, A., Sculean, A., & Eick, S. (2020) · Pathogens · doi:10.3390/pathogens9030178 · Cited by 13 · see citing works
“actinomycetemcomitans possesses several virulence factors, that is, lipopolysaccharides that induce pro-inflammatory cytokines, a cytolethal distending toxin causing cell cycle arrest in T-cells, macrophages and epithelial cells, and a leukotoxin [5].”
Background
The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells
Zhang, L., Cui, Y., Yang, Y., Wei, J., Liu, W., Cai, L., Wang, L., Zhang, D., Xie, J., & Cheng, L. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104991 · Cited by 13 · see citing works
What is the Potential Interplay between Microbiome and Tumor Microenvironment in Oral Squamous Cell Carcinomas?
Li, C., Liu, H., & Gong, Z. (2022) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2022.23.7.2199 · Cited by 11 · see citing works
“Aggregatibacter actinomycetemcomitans) which grow best at high concentrations of CO2 (5%~10%), can be detected in juvenile/localized aggressive periodontitis acting as the aetiology of this oral disease (Gholizadeh et al., 2017).”
Background
The antibacterial and antibiofilm role of cannabidiol against periodontopathogenic bacteria
Santos, A. L. O., Santiago, M. B., Silva, N. B. S., Souza, S. L., Duarte‐Almeida, J. M., & Martins, C. H. G. (2024) · Journal of Applied Microbiology · doi:10.1093/jambio/lxae316 · Cited by 12 · see citing works
Comparative Analysis of Cytokine Expression in Oral Keratinocytes and THP-1 Macrophages in Response to the Most Prevalent Serotypes of Aggregatibacter actinomycetemcomitans
Betancur, D., Muñoz, C., & Oñate, A. A. (2021) · Microorganisms · doi:10.3390/microorganisms9030622 · Cited by 11 · see citing works
“actinomycetemcomitans, a member of the periodontal dysbiotic biofilm, is a Gramnegative, non-motile, facultative anaerobic, and capnophilic coccobacillus [20,21].”
Background
Stable reconstructed human gingiva–microbe interaction model: Differential response to commensals and pathogens
Zhang, Y., Shang, L., Roffel, S., Krom, B. P., Gibbs, S., & Deng, D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.991128 · Cited by 10 · see citing works
“actinomycetemcomitans that affect the gingival epithelium and trigger the onset of periodontitis, including lipopolysaccharide (LPS), leukotoxin, cytolethal-distending toxin, collagenase and outer membrane protein (Gholizadeh et al., 2017).”
Background
Antibacterial activity of nitric oxide‐releasing carboxymethylcellulose against periodontal pathogens
Feura, E. S., Yang, L., & Schoenfisch, M. H. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37056 · Cited by 10 · see citing works
Expression of virulence factors under different environmental conditions in Aggregatibacter actinomycetemcomitans
Fujita, A., Oogai, Y., Kawada‐Matsuo, M., Nakata, M., Noguchi, K., & Komatsuzawa, H. (2021) · Microbiology and Immunology · doi:10.1111/1348-0421.12864 · Cited by 9 · see citing works
“actinomycetemcomitans LPS (lipopolysaccharide) stimulates gingival epithelial cells and immune cells, causing induction of the expression of inflammatory cytokines, such as IL (interleukin) ‐6, IL‐8, and IFN (interferon)‐γ.(1,2) In addition, other virulence factors, such as collagenase and heat shock protein GroEL, ha…”
BackgroundInfluential
Actinobacillus utilizes a binding protein–dependent ABC transporter to acquire the active form of vitamin B6
Pan, C., Zimmer, A., Shah, M. K., Huynh, M. S., Lai, C. C.-L., Sit, B., Hooda, Y., Curran, D. M., & Moraes, T. F. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101046 · Cited by 9 · see citing works
“aphrophilus), and periodontal diseases (Aggregatibacter actinomycetemcomitans) (29, 30).”
Persister Cell Formation and Elevated lsrA and lsrC Gene Expression upon Hydrogen Peroxide Exposure in a Periodontal Pathogen Aggregatibacter actinomycetemcomitans
Nakamura, Y., Watanabe, K., Yoshioka, Y., Ariyoshi, W., & Yamasaki, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061402 · Cited by 9 · see citing works
Diversity of Bacteroidaceae family in gut microbiota of patients with chronic kidney disease and end stage renal disease
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Authors: Gholizadeh, P., Pormohammad, A., Eslami, H., Shokouhi, B., Fakhrzadeh, V., & Kafil, H. S.
Affiliations: Tabriz University of Medical Sciences (IR)
Shahid Beheshti University (IR)
Corresponding author: Kafil, Hossein Samadi
ORCID: Gholizadeh, Pourya
Pormohammad, Ali
Eslami, Hosein
Shokouhi, Behrooz
Fakhrzadeh, Vahid
Kafil, Hossein Samadi
Venue: Microbial Pathogenesis
Publisher: Elsevier BV
Published: 2017-12
Volume: 113
Pages: 303-311
ISSN: 0882-4010 (ISSN-L)
DOI: 10.1016/j.micpath.2017.11.001
OpenAlex: W2766741310
Cited by: 144
References: 175
Citations by year: 2026: 11 · 2025: 18 · 2024: 19 · 2023: 18 · 2022: 20 · 2021: 22 · 2020: 18 · 2019: 10 · 2018: 8
FWCI: 1.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Microbial Pathogenesis (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Medical Research Development (NIMAD)
Drug Applied Research Center, Tabriz University of Medical Sciences
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: Aggregatibacter actinomycetemcomitans, periodontal disease, localized aggressive periodontitis, bone resorption, virulence factors, leukotoxin, lipopolysaccharide, GroEL, DnaK, HtpG, CDT, host immune response, cytokines, periodontal inflammation
MeSH terms: Bacterial Proteins, Bacterial Toxins, Bone Resorption, Exotoxins, Immune System, Immunity, Innate, Lipopolysaccharides, Aggressive Periodontitis, Cytokines, Pasteurellaceae Infections, Aggregatibacter actinomycetemcomitans, Biofilms, Virulence Factors, Host-Pathogen Interactions, Adaptive Immunity

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Oral pathogenesis of Aggregatibacter actinomycetemcomitans

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