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Emerging resistance mechanisms for 4 types of common anti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review
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“The accumulation of mutations in genes encoding binary regulatory systems such as WalKR (sensor protein kinase/regulator), GraSR (glycopeptide resistance-associated sensor/regulator), and VraSR (vancomycin resistance associated sensor/regulator) plays a major role in the formation of hVISA/VISA strains [75].”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [75]
In the citing paper
“Amino acid substitutions in the PBP2A protein such as L357I, E447K, I563T, and S649A in the BND (penicillin-binding domain) and substitutions N104K, V117I, N146K and A228V located outside the BND have also been shown to be responsible for ceftaroline resistance in MRSA strains [75,76].”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [75]
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“These mechanisms also determine resistance to lincosamides, phenicols, streptograminA and pleuromutilin [75].”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [75]
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“In one linezolid-resistant S. aureus strain another mutation of the rrl5 gene, namely T2500A, was found, in the absence of G2576U, G2447T mutations were also described [75,96].”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [75]
In the citing paper
“Resistance or reduced sensitivity to daptomycin is probably related to mutations in the mprF gene encoding lysyl-phosphatidylglycerol synthetase (N352K substitution in MprF), dltABCD operon responsible for D-alanine attachment to teichoic acids in the cell wall (substitutions of N276S in DltB and P309L inDltD), vraSR regulatory genes and clpP (ATP-dependent Clp protease; G74S substitution), rpoC (”
From Molecular Mechanisms of Drug Resistance in Staphylococcus aureus (2022) · cites this paper as [75]
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Intrinsic and acquired resistance mechanisms in enterococcus
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Cited by
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus
Mlynarczyk-Bonikowska, B., Kowalewski, C., Krolak-Ulinska, A., & Marusza, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158088 · Cited by 412
Metadata
- Authors
- Liu, W.-T., Chen, E.-Z., Yang, L., Peng, C., Wang, Q., Xu, Z., & Chen, D.-Q.
- ORCID
- Xu, Zhenbo
- Venue
- Microbial Pathogenesis
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 156
- Pages
- 104915
- ISSN
- 0882-4010
- Cited by
- 138
- References
- 1
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- National Natural Science Foundation of China
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