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Antidepressants during pregnancy: Guideline adherence and current practice amongst Dutch gynaecologists and midwives
Open accessAbstract
Background and objectives prescription rates of antidepressants during pregnancy range from 2-3% in The Netherlands to 6.2% in the USA. Inconclusive evidence about harms and benefits of antidepressants during pregnancy leads to variation in advice given by gynaecologists and midwives. The objective was to investigate familiarity with, and adherence to the Dutch multidisciplinary guideline on Selective Serotonin Reuptake Inhibitor (SSRI) use during pregnancy by gynaecologists and midwives in the Netherlands.Methods an online survey was developed and send to Dutch gynaecologists and midwives. The survey consisted mainly of multiple-choice questions addressing guideline familiarity and current practice of the respondent. Also, caregiver characteristics associated with guideline adherence were investigated.Findings a total of 178 gynaecologists and 139 midwives responded. Overall familiarity with the Dutch guideline was 92.7%. However, current practice and advice given to patients by caregivers differed substantially, both between gynaecologists and midwives as well as within both professions. Overall guideline adherence was 13.9%. Multivariable logistic regression showed that solely caregiver profession was associated with guideline adherence, with gynaecologists having a higher adherence rate (OR 2.10, 95%CI 1.02-4.33) than midwives.Key conclusion although reported familiarity with the guideline is high, adherence to the guideline is low, possibly resulting in advice to patients that is inconsistent with guidelines and unwanted variation in current practice.Implications for practice further implementation of the recommendations as given in the guideline should be stimulated. Additional research is needed to examine how gynaecologists and midwives can be facilitated to follow the recommendations of the clinical guideline on SSRI use during pregnancy.
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Research works printed but not linked: 1
- Mistiaen P, Bloemendal, E., Weening, J. W., Harmsen, M., 2012. Guideline adherence in the Netherlands: a systematic review. G-I-N Conference. 〈http://www.g-i-n.net/document-store/g-i-n-conferences/berlin-2012/orals/o57-mistiaen.pdf〉.
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O’Connor, E., Senger, C. A., Henninger, M. L., Coppola, E., & Gaynes, B. N. (2019) · JAMA · doi:10.1001/jama.2018.20865 · Cited by 316
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Metadata
- Authors
- Molenaar, N. M., Brouwer, M. E., Duvekot, J. J., Burger, H., Knijff, E. M., Hoogendijk, W. J., Bockting, C. L. H., de Wolf, G. S., & Lambregtse-van den Berg, M. P.
- Affiliations
- Erasmus MC (NL)
- Utrecht University (NL)
- University Medical Center Groningen (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Molenaar, Nina M.
- ORCID
- Venue
- Midwifery
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 61
- Pages
- 29-35
- ISSN
- 0266-6138 (ISSN-L)
- OpenAlex
- W2788078649
- Cited by
- 14
- References
- 31
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 7
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Midwifery (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- ZonMw, The Netherlands Organisation for Health Research and Development (836021011)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- selective serotonin reuptake inhibitors, guideline adherence, gynecologists, midwives, clinical practice variation, guideline implementation, maternal mental health
- MeSH terms
- Workforce, Adult, Antidepressive Agents, Cross-Sectional Studies, Female, Gynecology, Humans, Male, Middle Aged, Netherlands, Nurse Midwives, Practice Patterns, Physicians', Physicians, Pregnancy, Prenatal Care, Surveys and Questionnaires, Logistic Models, Guideline Adherence
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