Use of antidepressant medications during pregnancy: a multisite study

Andrade, Susan E.; Raebel, Marsha A.; Brown, Jeffrey; Lane, Kimberly; Livingston, James; Boudreau, Denise; Rolnick, Sharon J.; Roblin, Douglas; Smith, David H.; Willy, Mary E.; Staffa, Judy A.; Platt, Richard

doi:10.1016/j.ajog.2007.07.036

Cited by 403Pregnancy and Medication ImpactMaternal Mental Health During Pregnancy and PostpartumPrenatal Substance Exposure Effects

Use of antidepressant medications during pregnancy: a multisite study

Andrade, Susan E., Raebel, Marsha A., Brown, Jeffrey, Lane, Kimberly, Livingston, James, Boudreau, Denise, Rolnick, Sharon J., Roblin, Douglas +4 more·2008·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2007.07.036

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Abstract

Objective This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States.Study design A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days.Results Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin reuptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005.Conclusion Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman.

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Only 2-8% of pregnant women are currently estimated to use antidepressants.
“Although pharmacological treatment is effective and can be safely utilized during pregnancy under medical supervision, only 2–8% of pregnant women are currently estimated to use antidepressants (23–26).”
From Acceptance, experiences, and needs of hospitalized pregnant women toward an electronic mindfulness-based intervention: A pilot mixed-methods study (2022) · cites this paper as [23]

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Authors: Andrade, S. E., Raebel, M. A., Brown, J., Lane, K., Livingston, J., Boudreau, D., Rolnick, S. J., Roblin, D., Smith, D. H., Willy, M. E., Staffa, J. A., & Platt, R.
Affiliations: University of Massachusetts Chan Medical School (US)
Kaiser Permanente (US)
Harvard University (US)
Group Health Cooperative (US)
HealthPartners (US)
United States Food and Drug Administration (US)
Corresponding author: Andrade, Susan E.
ORCID: Andrade, Susan E.
Raebel, Marsha A.
Brown, Jeffrey
Boudreau, Denise
Smith, David H.
Staffa, Judy A.
Platt, Richard
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2008-02
Volume: 198
Issue: 2
Pages: 194.e1-194.e5
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2007.07.036
OpenAlex: W2063638540
Cited by: 403
References: 18
Citations by year: 2026: 1 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 17 · 2021: 9 · 2020: 24 · 2019: 24 · 2018: 24 · 2017: 27 · 2016: 38 · 2015: 37 · 2014: 28 · 2013: 43 · 2012: 39
FWCI: 15.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: antidepressant use in pregnancy, selective serotonin reuptake inhibitors, maternal mental health, prenatal drug exposure, health insurance claims
MeSH terms: Adolescent, Adult, Antidepressive Agents, Depressive Disorder, Female, Health Maintenance Organizations, Humans, Infant, Newborn, Middle Aged, Practice Patterns, Physicians', Pregnancy, Pregnancy Complications, Prenatal Care, Retrospective Studies, United States, Databases, Factual, Selective Serotonin Reuptake Inhibitors, Drug Utilization Review

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Use of antidepressant medications during pregnancy: a multisite study

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