The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Are fentanyl and remifentanil safe opioids for rat brain mitochondrial bioenergetics?
Abstract
Fentanyl and remifentanil are potent opioid widely used in routine anesthesia procedures. This study evaluates and compares the effects of fentanyl/remifentanil in isolated brain mitochondria bioenergetic status. Fentanyl and remifentanil in clinical concentrations does not interfere with rat brain isolated mitochondria. Do not withstand, fentanyl concentrations >4 microg/mL, induces an impairment of the respiratory chain characterized by a decrease in respiratory control ratio, state 3 and uncoupled respiration. Additionally, membrane potential collapses and ADP/O were reduced. Remifentanil follows the same profile but with effects at higher concentrations (>10 microg/mL). High concentrations of fentanyl and remifentanil interfere with mitochondrial electron chain (complexes III, IV) and on mitochondrial phosphorylation unit (complex V). Mitochondrial permeability transition pore was not induced by both fentanyl and remifentanil in tested concentrations. These data provide the first indication that fentanyl and remifentanil (microg/mL range) alters mitochondrial metabolism. Fentanyl showed a stronger inhibitory effect on mitochondrial bioenergetics.
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“pre- or post-injury administration of analgesics can influence the nature of brain injury, as well as mitochondrial function and microRNA activity [38–40].”
From The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs (2020) · cites this paper as [39]
Citations
Cites
DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION
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Determination of the Activity of Succinate, NADH, Choline, and α‐Glycerophosphate Dehydrogenases
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Cerebral Ischemia and Reperfusion: Prevention of Brain Mitochondrial Injury by Lidoflazine
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Research works printed but not linked: 2
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- Ferreira, 2007, Remifentanil lowers SVjO2: clinical study in neurosurgical patients under BIS monitoring, Anesthesiology, 107, A3
Cited by
Wang, W.-X., Prajapati, P., Nelson, P. T., & Springer, J. E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01937-y · Cited by 49
Metadata
- Authors
- Vilela, S. M. F., Santos, D. J. S. L., Félix, L., Almeida, J. M., Antunes, L., & Peixoto, F.
- Venue
- Mitochondrion
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 9
- Issue
- 4
- Pages
- 247-253
- ISSN
- 1567-7249
- Cited by
- 19
- References
- 37
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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