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Cited by 19

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Are fentanyl and remifentanil safe opioids for rat brain mitochondrial bioenergetics?

Vilela, Sérgio M.F., Santos, Dario J.S.L., Félix, Luis, Almeida, José M., Antunes, Luis, Peixoto, Francisco·2009·Mitochondrion
DOI 10.1016/j.mito.2009.03.002
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Abstract

Fentanyl and remifentanil are potent opioid widely used in routine anesthesia procedures. This study evaluates and compares the effects of fentanyl/remifentanil in isolated brain mitochondria bioenergetic status. Fentanyl and remifentanil in clinical concentrations does not interfere with rat brain isolated mitochondria. Do not withstand, fentanyl concentrations >4 microg/mL, induces an impairment of the respiratory chain characterized by a decrease in respiratory control ratio, state 3 and uncoupled respiration. Additionally, membrane potential collapses and ADP/O were reduced. Remifentanil follows the same profile but with effects at higher concentrations (>10 microg/mL). High concentrations of fentanyl and remifentanil interfere with mitochondrial electron chain (complexes III, IV) and on mitochondrial phosphorylation unit (complex V). Mitochondrial permeability transition pore was not induced by both fentanyl and remifentanil in tested concentrations. These data provide the first indication that fentanyl and remifentanil (microg/mL range) alters mitochondrial metabolism. Fentanyl showed a stronger inhibitory effect on mitochondrial bioenergetics.

Overview

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Registry

Crossref · 10.1016/j.mito.2009.03.002

Cites

37 of 37 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 2

  1. Chance, 1956, The respiration chain and oxidative phosphorylation, Adv. Enzymol., 17, 134
  2. Ferreira, 2007, Remifentanil lowers SVjO2: clinical study in neurosurgical patients under BIS monitoring, Anesthesiology, 107, A3

Cited by

See all 19

Metadata

Authors
Vilela, S. M. F., Santos, D. J. S. L., Félix, L., Almeida, J. M., Antunes, L., & Peixoto, F.
Venue
Mitochondrion
Publisher
Elsevier BV
Published
2009-07
Volume
9
Issue
4
Pages
247-253
ISSN
1567-7249
DOI
10.1016/j.mito.2009.03.002
Cited by
19
References
37
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.