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XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in xenopus embryos.
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Dilution will diminish expression of age-elevated autoinducers and feedback will decrease their levels for a prolonged time.
“where dilution will diminish their expression and feedback will decrease the levels for a prolonged time [48–56].”
From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [54]
Section 2.4 describes a regulatory loop among xXBP1, BMP-4, and Xvent-2 in Xenopus embryos, but does not examine dilution or whether it causes a prolonged decrease in expression. Searches for dilution, autoinducers, aging, and prolonged feedback effects found no passage addressing that claim. (LLM, conf=0.73)
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CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
DORSAL-VENTRAL PATTERNING AND NEURAL INDUCTION IN XENOPUS EMBRYOS
De Robertis, E. M., & Kuroda, H. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.011403.154124 · Cited by 671
The establishment of spemann's organizer and patterning of the vertebrate embryo
De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O. (2000) · Nature Reviews Genetics · doi:10.1038/35042039 · Cited by 429
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Research works printed but not linked: 52
- Ault, 1996, A novel homeobox gene PV.1 mediates induction of ventral mesoderm in Xenopus embryos, Proc. Natl Acad. Sci. USA, 93, 6415, 10.1073/pnas.93.13.6415 · DOI
- Bai, 2002, A nuclear antagonistic mechanism of inhibitory Smads in transforming growth factor-beta signaling, J. Biol. Chem., 277, 4176, 10.1074/jbc.M105105200 · DOI
- Bai, 2000, Smad6 as a transcriptional corepressor, J. Biol. Chem., 275, 8267, 10.1074/jbc.275.12.8267 · DOI
- Cao, 2004, The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos, J. Biol. Chem., 279, 43735, 10.1074/jbc.M407544200 · DOI
- Chan, 2001, p300/CBP proteins: HATs for transcriptional bridges and scaffolds, J. Cell Sci., 114, 2363, 10.1242/jcs.114.13.2363 · DOI · Paper page
- Clauss, 1996, The basic domain/leucine zipper protein hXBP1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core, Nucl. Acids Res., 24, 1855, 10.1093/nar/24.10.1855 · DOI
- Friedle, 2002, Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B, J. Biol. Chem., 277, 23872, 10.1074/jbc.M201831200 · DOI
- Harland, 1991, In situ hybridization: an improved whole-mount method for Xenopus embryos, Methods Cell Biol., 36, 685, 10.1016/S0091-679X(08)60307-6 · DOI
- Hata, 1998, Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor, Genes Dev., 12, 186, 10.1101/gad.12.2.186 · DOI
- Hata, 2000, OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways, Cell, 100, 229, 10.1016/S0092-8674(00)81561-5 · DOI
- Hayashi, 1997, The MAD-Related Protein Smad7 Associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling, Cell, 89, 1165, 10.1016/S0092-8674(00)80303-7 · DOI
- Henningfeld, 2000, Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter, J. Biol. Chem., 275, 21827, 10.1074/jbc.M000978200 · DOI
- Henningfeld, 2002, Autoregulation of Xvent-2B: Direct interaction and functional cooperation of Xvent-2 and Smad1, J. Biol. Chem., 277, 2097, 10.1074/jbc.M108524200 · DOI
- Imamura, 1997, Smad6 inhibits signaling by the TGF-β superfamily, Nature, 389, 622, 10.1038/39355 · DOI
- Itoh, 1998, Transforming growth factor β1 induces nuclear export of inhibitory Smad7, J. Biol. Chem., 273, 29195, 10.1074/jbc.273.44.29195 · DOI
- Itoh, 2000, Signaling of transforming growth factor-b family members through Smad proteins, Eur. J. Biochem., 267, 6954, 10.1046/j.1432-1327.2000.01828.x · DOI
- Jones, 1996, Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos, Development, 122, 1545, 10.1242/dev.122.5.1545 · DOI
- Knöchel, 2000, c-Jun (AP-1) activates BMP-4 transcription in Xenopus embryos, Mech. Dev., 98, 29, 10.1016/S0925-4773(00)00448-2 · DOI
- Ladher, 1996, Xom: a Xenopus homeobox gene that mediates the early effects of BMP-4, Development, 122, 2385, 10.1242/dev.122.8.2385 · DOI
- Lee, 2002, IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response, Genes Dev., 15, 452, 10.1101/gad.964702 · DOI
- Lee, 2003, XBP1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response, Mol. Cell. Biol., 23, 7448, 10.1128/MCB.23.21.7448-7459.2003 · DOI
- Lin, 2003, Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein- induced transcription, Mol. Cell. Biol., 23, 9081, 10.1128/MCB.23.24.9081-9093.2003 · DOI
- Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., et al., 1999. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287–298. · DOI · Paper page
- Moos, 1995, Anti-dorsalizing morphogenetic protein is a novel TGF-beta homolog expressed in the Spemann organizer, Development, 121, 4293, 10.1242/dev.121.12.4293 · DOI
- Nakao, 1997, Identification of Smad7, a TGFβ-inducible antagonist of TGFβ signaling, Nature, 389, 631, 10.1038/39369 · DOI
- Nakayama, 1998, Smad6 functions as an intracellular antagonist of some TGFβ family members during Xenopus embryogenesis, Gene Cells, 3, 387, 10.1046/j.1365-2443.1998.00196.x · DOI
- Nakayama, 1998, Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning, Development, 125, 857, 10.1242/dev.125.5.857 · DOI
- Nakayama, 2001, Dissection of inhibitory Smad proteins: both N- and C-terminal domains are necessary for full activities of Xenopus Smad6 and Smad7, Mech. Dev., 100, 251, 10.1016/S0925-4773(00)00533-5 · DOI
- Onichtchouk, 1998, Requirement for Xvent-1 and Xvent-2 gene function in dorsoventral patterning of Xenopus mesoderm, Development, 125, 1447, 10.1242/dev.125.8.1447 · DOI
- Osada, 1999, Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis, Development, 126, 3229, 10.1242/dev.126.14.3229 · DOI
- Oswald, 2001, p300 acts as a transcriptional coactivator for mammalian notch-1, Mol. Cell. Biol., 21, 7761, 10.1128/MCB.21.22.7761-7774.2001 · DOI
- Piccolo, 1999, The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals, Nature, 397, 707, 10.1038/17820 · DOI
- Reimold, 2000, An essential role in liver development for transcription factor XBP1, Genes Dev., 14, 152, 10.1101/gad.14.2.152 · DOI
- Reimold, 2001, Plasma cell differentiation requires the transcription factor XBP1, Nature, 412, 300, 10.1038/35085509 · DOI
- Schier, 2003, Nodal signaling in vertebrate development, Annu. Rev. Cell Dev. Biol., 19, 589, 10.1146/annurev.cellbio.19.041603.094522 · DOI
- Schier, 1999, Nodal signaling in vertebrate development, Nature, 403, 385, 10.1038/35000126 · DOI
- Schuler-Metz, 2000, The homeodomain transcription factor Xvent-2 mediates auto-catalytic regulation of BMP-4 expression in Xenopus embryos, J. Biol. Chem., 275, 34365, 10.1074/jbc.M003915200 · DOI
- Shi, 2003, Mechanisms of TGF-β signaling from cell membrane to the nucleus, Cell, 113, 685, 10.1016/S0092-8674(03)00432-X · DOI
- Smith, 1995, A nodal related gene defines a physical and functional domain within the Spemann organizer, Cell, 82, 37, 10.1016/0092-8674(95)90050-0 · DOI
- Sriburi, 2004, XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum, J. Cell Biol., 167, 35, 10.1083/jcb.200406136 · DOI · Paper page
- Suzuki, 1994, A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo, Proc. Natl Acad. Sci. USA, 91, 10255, 10.1073/pnas.91.22.10255 · DOI
- Thisse, 1999, Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction, Development, 126, 229, 10.1242/dev.126.2.229 · DOI
- Thisse, 2000, Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo, Nature, 403, 425, 10.1038/35000200 · DOI
- von Bubnoff, 2001, Intracellular BMP signaling regulation in vertebrates: pathway or network?, Dev. Biol., 239, 1, 10.1006/dbio.2001.0388 · DOI
- Whitman, 1998, Smads and early developmental signaling by the TGFβ superfamily, Genes Dev., 12, 2445, 10.1101/gad.12.16.2445 · DOI
- Whitman, 2001, Nodal signaling in early vertebrate embryos: themes and variations, Dev. Cell, 1, 605, 10.1016/S1534-5807(01)00076-4 · DOI
- Wiedenmann, 2004, EosFP, a fluorescent marker protein with UV-inducible green-to-red fluorescence conversion, Proc. Natl Acad. Sci. USA, 101, 15905, 10.1073/pnas.0403668101 · DOI
- Wilson, 1995, Induction of epidermis and inhibition of neural fate by Bmp-4, Nature, 376, 331, 10.1038/376331a0 · DOI · Paper page
- Xu, 1999, Opposite effects of FGF and BMP-4 on embryonic blood formation: roles of PV.1 and GATA-2, Dev. Biol., 208, 352, 10.1006/dbio.1999.9205 · DOI
- Yoshida, 2001, XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor, Cell, 107, 881, 10.1016/S0092-8674(01)00611-0 · DOI
- Zhao, 2003, Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway, Dev. Biol., 257, 278, 10.1016/S0012-1606(03)00069-1 · DOI
- Zhu, 1999, Smad7 differentially regulates transforming growth factor β-mediated signaling pathways, J. Biol. Chem., 274, 32258, 10.1074/jbc.274.45.32258 · DOI
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Sorted by citations
Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
Mehdipour, M., Skinner, C., Wong, N., Lieb, M., Liu, C., Etienne, J., Kato, C., Kiprov, D., Conboy, M. J., & Conboy, I. M. (2020) · Aging · doi:10.18632/aging.103418 · Cited by 115
Metadata
- Authors
- Cao, Y., Knöchel, S., Oswald, F., Donow, C., Zhao, H., & Knöchel, W.
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 123
- Issue
- 1
- Pages
- 84-96
- ISSN
- 0925-4773
- Cited by
- 30
- References
- 3
- Language
- en
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