p300/CBP proteins: HATs for transcriptional bridges and scaffolds
Abstract
p300/CBP transcriptional co-activator proteins play a central role in co-ordinating and integrating multiple signal-dependent events with the transcription apparatus, allowing the appropriate level of gene activity to occur in response to diverse physiological cues that influence, for example, proliferation, differentiation and apoptosis. p300/CBP activity can be under aberrant control in human disease, particularly in cancer, which may inactivate a p300/CBP tumour-suppressor-like activity. The transcription regulating-properties of p300 and CBP appear to be exerted through multiple mechanisms. They act as protein bridges, thereby connecting different sequence-specific transcription factors to the transcription apparatus. Providing a protein scaffold upon which to build a multicomponent transcriptional regulatory complex is likely to be an important feature of p300/CBP control. Another key property is the presence of histone acetyltransferase (HAT) activity, which endows p300/CBP with the capacity to influence chromatin activity by modulating nucleosomal histones. Other proteins, including the p53 tumour suppressor, are targets for acetylation by p300/CBP. With the current intense level of research activity, p300/CBP will continue to be in the limelight and, we can be confident, yield new and important information on fundamental processes involved in transcriptional control.
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P300 and CBP serve as scaffolds that connect RNA polymerase II and RNAP-associated general transcription factors to chromatin.
“P300 and CBP also serve as scaffolds that connect RNA polymerase II (RNAP) and RNAP-associated “general transcription factors” to the chromatin [64, 65].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [64]
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- Authors
- Chan, H. M., & La Thangue, N. B.
- Affiliations
- University of Glasgow (GB)
- Division of Biochemistry and Molecular Biology, Davidson Building, University of Glasgow, Glasgow, G12 8QQ, UK
- ORCID
- Chan, Ho Man
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2001-07-01
- Volume
- 114
- Issue
- 13
- Pages
- 2363-2373
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1900657670
- Cited by
- 1,092
- References
- 9
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 21 · 2023: 35 · 2022: 33 · 2021: 47 · 2020: 51 · 2019: 34 · 2018: 33 · 2017: 35 · 2016: 40 · 2015: 40 · 2014: 45 · 2013: 49 · 2012: 46
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Keywords
- P300, CBP, histone acetyltransferase, transcriptional coactivator, protein scaffolds, transcriptional regulation, chromatin regulation, histone acetylation, p53 acetylation, tumor suppression, cancer
- MeSH terms
- Acetyltransferases, Cell Cycle, Chromatin, Gene Expression Regulation, Neoplasms, Nuclear Proteins, Transcription, Genetic, Signal Transduction, Trans-Activators, Saccharomyces cerevisiae Proteins, Histone Acetyltransferases
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