The Rb-Related p130 Protein Controls Telomere Lengthening through an Interaction with a Rad50-Interacting Protein, RINT-1
Open accessAbstract
The oncogenic process often leads to a loss of normal telomere length control, usually as a result of activation of telomerase. Nevertheless, there are also telomerase-independent events that involve a Rad50-dependent recombination mechanism to maintain telomere length. Previous work has implicated the Rb family of proteins in the control of telomere length, and we now demonstrate that the p130 member of the Rb family is critical for telomere length control. p130 interacts specifically with the RINT-1 protein, previously identified as a Rad50-interacting protein. We further show that RINT-1 is essential for telomere length control. We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. Given previous work implicating E2F in the control of telomerase gene expression, these results thus point to complementary roles for the Rb/E2F pathway in the control of telomere length.
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The RB family transmits signals that induce senescence in cells with shortened telomeres.
“Furthermore, the RB family controls the length of telomeres and mediates the cellular signals to induce senescence in cells with shortened telomeres125–127.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [126]
The RB family regulates telomere length.
“Furthermore, the RB family controls the length of telomeres and mediates the cellular signals to induce senescence in cells with shortened telomeres125–127.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [126]
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
Brummelkamp, T. R., Bernards, R., & Agami, R. (2002) · Science · doi:10.1126/science.1068999 · Cited by 4,295 · see citing works
A survey of telomerase activity in human cancer
Shay, J. W., & Bacchetti, S. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(97)00062-2 · Cited by 2,794 · see citing works
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317 · see citing works
Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096 · see citing works
Plat-E: an efficient and stable system for transient packaging of retroviruses
MORITA, S., Kojima, T., & Kitamura, T. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301206 · Cited by 1,660 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
The E2F transcription factor is a cellular target for the RB protein
Chellappan, S., Hiebert, S. W., Mudryj, M. M., Horowitz, J. M., & Nevins, J. R. (1991) · Cell · doi:10.1016/0092-8674(91)90557-f · Cited by 1,415 · see citing works
Self-citationTelomere states and cell fates
Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,372 · see citing works
Telomere elongation in immortal human cells without detectable telomerase activity
Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., & Reddel, R. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00098.x · Cited by 1,279 · see citing works
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219 · see citing works
Nevins, J. R. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.699 · Cited by 920 · see citing works
Self-citationHuman Telomerase and Its Regulation
Cong, Y.-S., Wright, W. E., & Shay, J. W. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.407-425.2002 · Cited by 898 · see citing works
Telomere maintenance by recombination in human cells
Dunham, M. A., Neumann, A. A., Fasching, C. L., & Reddel, R. R. (2000) · Nature Genetics · doi:10.1038/82586 · Cited by 879 · see citing works
Structure and variability of human chromosome ends.
de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., & Varmus, H. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518 · Cited by 848 · see citing works
Control of Human Telomere Length by TRF1 and TRF2
Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768 · see citing works
Telomerase maintains telomere structure in normal human cells
Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738 · see citing works
The retinoblastoma tumour suppressor in development and cancer
Classon, M., & Harlow, E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc950 · Cited by 738 · see citing works
Yeager, T. R., Neumann, A. A., Englezou, A., Huschtscha, L. I., Noble, J. R., & Reddel, R. R. (1999) · PubMed · Cited by 678 · see citing works
Myc activates telomerasePreprint
Wang, J., Xie, L. Y., Allan, S., Beach, D., & Hannon, G. J. (1998) · Genes & Development · doi:10.1101/gad.12.12.1769 · Cited by 653 · see citing works
Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
Zhu, X., Küster, B., Mann, M., Petrini, J. H. J., & de Lange, T. (2000) · Nature Genetics · doi:10.1038/77139 · Cited by 602 · see citing works
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
Sage, J., Miller, A. L., Pérez-Mancera, P. A., Wysocki, J. M., & Jacks, T. (2003) · Nature · doi:10.1038/nature01764 · Cited by 538 · see citing works
Toward an understanding of the functional complexity of the E2F and retinoblastoma families.
Nevins, J. R. (1998) · PubMed · Cited by 514 · see citing works
Self-citationHallmarks of senescence in carcinogenesis and cancer therapy
Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502 · see citing works
Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase
Lin, S., & Elledge, S. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00430-6 · Cited by 427 · see citing works
Hu, Q., Dyson, N. J., & Harlow, E. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08221.x · Cited by 315 · see citing works
Telomeres, Telomerase and Cancer
Greider, C. W., & Blackburn, E. H. (1996) · Scientific American · doi:10.1038/scientificamerican0296-92 · Cited by 314 · see citing works
E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control
Gaubatz, S., Lindeman, G. J., Ishida, S., Jakoi, L., Nevins, J. R., Livingston, D. M., & Rempel, R. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00071-x · Cited by 300 · see citing works
Self-citationHoughtaling, B. R., Cuttonaro, L., Chang, W., & Smith, S. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.052 · Cited by 284 · see citing works
Chen, Q., IJpma, A. S., & Greider, C. W. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1819-1827.2001 · Cited by 275 · see citing works
Gewin, L. C., Myers, H. E., Kiyono, T., & Galloway, D. A. (2004) · Genes & Development · doi:10.1101/gad.1214704 · Cited by 267 · see citing works
Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins
Helt, A.-M. (2003) · Carcinogenesis · doi:10.1093/carcin/24.2.159 · Cited by 250 · see citing works
Wu, G., Lee, W., & Chen, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000390200 · Cited by 209 · see citing works
Replication Factors MCM2 and ORC1 Interact with the Histone Acetyltransferase HBO1
Burke, T. W., Cook, J. G., Asano, M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011556200 · Cited by 198 · see citing works
Kaelin, W. G., Ewen, M. E., & Livingston, D. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3761 · Cited by 197 · see citing works
Huang, S., Wang, N., Tseng, B., Lee, W., & Lee, E. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08306.x · Cited by 196 · see citing works
E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability
Humbert, P. O., Rogers, C., Ganiatsas, S., Landsberg, R. L., Trimarchi, J. M., Dandapani, S. V., Brugnara, C., Erdman, S. E., Schrenzel, M. D., Bronson, R. T., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00029-0 · Cited by 193 · see citing works
Alternative lengthening of telomeres, telomerase, and cancer
Reddel, R. R. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00702-4 · Cited by 191 · see citing works
Regulation of the human telomerase reverse transcriptase gene
Ducrest, A., Szutorisz, H., Lingner, J., & Nabholz, M. (2002) · Oncogene · doi:10.1038/sj.onc.1205081 · Cited by 184 · see citing works
Meloni, A. R., Smith, E., & Nevins, J. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9574 · Cited by 183 · see citing works
Self-citationTelomere maintenance without telomerase
Lundblad, V. (2002) · Oncogene · doi:10.1038/sj.onc.1205079 · Cited by 182 · see citing works
Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages
Rempel, R. E., Sáenz-Robles, M. T., Storms, R. W., Morham, S. G., Ishida, S., Engel, A., Jakoi, L., Melhem, M. F., Pipas, J. M., Smith, C. A., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00030-7 · Cited by 171 · see citing works
Self-citationJiang, W.-Q., Zhong, Z.-H., Henson, J. D., Neumann, A. A., Chang, A. C.-M., & Reddel, R. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2708-2721.2005 · Cited by 155 · see citing works
Telomere maintenance and cancer ? look, no telomerase
Neumann, A. A., & Reddel, R. R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc929 · Cited by 148 · see citing works
E2F-1 represses transcription of the human telomerase reverse transcriptase gene
Crowe, D. L. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2789 · Cited by 135 · see citing works
A role for the Rb family of proteins in controlling telomere length
García-Cao, M., Gonzalo, S., Dean, D., & Blasco, M. A. (2002) · Nature Genetics · doi:10.1038/ng1011 · Cited by 120 · see citing works
Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells
Balciunaite, E., Spektor, A., Lents, N. H., Cam, H., te Riele, H., Scime, A., Rudnicki, M. A., Young, R., & Dynlacht, B. D. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8166-8178.2005 · Cited by 116 · see citing works
Stöppler, H., Hartmann, D.-P., Sherman, L., & Schlegel, R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13332 · Cited by 115 · see citing works
Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids
Perrem, K., Bryan, T. M., Englezou, A., Hackl, T., Moy, E. L., & Reddel, R. R. (1999) · Oncogene · doi:10.1038/sj.onc.1202752 · Cited by 109 · see citing works
Identification of E-Box Factor TFE3 as a Functional Partner for the E2F3 Transcription Factor
Giangrande, P. H., Hallstrom, T. C., Tunyaplin, C., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.11.3707-3720.2003 · Cited by 104 · see citing works
The retinoblastoma family: twins or distant cousins?
Claudio, P. P., Tonini, T., & Giordano, A. (2002) · Genome biology · doi:10.1186/gb-2002-3-9-reviews3012 · Cited by 85 · see citing works
RINT-1, a Novel Rad50-interacting Protein, Participates in Radiation-induced G2/M Checkpoint Control
Xiao, J., Liu, C.-C., Chen, P., & Lee, W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008893200 · Cited by 65 · see citing works
Rb and E2F-1 regulate telomerase activity in human cancer cells
Crowe, D. L., & Nguyen, D. C. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(00)00296-7 · Cited by 50 · see citing works
Won, J., Chang, S., Oh, S., & Kim, T. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401801101 · Cited by 44 · see citing works
Yamamoto, A., Kumakura, S., Uchida, M., Barrett, J. C., & Tsutsui, T. (2003) · International Journal of Cancer · doi:10.1002/ijc.11219 · Cited by 38 · see citing works
Quante, M., Heeg, S., von Werder, A., Goessel, G., Fulda, C., Doebele, M., Nakagawa, H., Beijersbergen, R. L., Blum, H. E., & Opitz, O. G. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi153 · Cited by 16 · see citing works
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Cellular mechanisms of tumour suppression by the retinoblastoma gene
Burkhart, D. L., & Sage, J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2399 · Cited by 974 · see citing works
- Authors
- Kong, L.-J., Meloni, A. R., & Nevins, J. R.
- Affiliations
- Duke University (US)
- Corresponding author
- Nevins, Joseph R.
- ORCID
- Kong, Ling-Jie
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 22
- Issue
- 1
- Pages
- 63-71
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2030132370
- Cited by
- 48
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 6
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- p130, Rb family proteins, telomere length control, RAD50, E2F transcription factors, tumor suppressor proteins
- MeSH terms
- Cells, Cultured, DNA-Binding Proteins, Humans, Saccharomyces cerevisiae, Telomere, Cell Cycle Proteins, Telomerase, Two-Hybrid System Techniques, RNA, Small Interfering, Immunoprecipitation, Retinoblastoma-Like Protein p130
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