p97: The Cell's Molecular Purgatory?

Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol

Ye, Y., Meyer, H. H., & Rapoport, T. A. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302169 · Cited by 598 · see citing works

A Series of Ubiquitin Binding Factors Connects CDC48/p97 to Substrate Multiubiquitylation and Proteasomal Targeting

Richly, H., Rapé, M., Braun, S. J., Rumpf, S., Hoege, C., & Jentsch, S. (2005) · Cell · doi:10.1016/j.cell.2004.11.013 · Cited by 523 · see citing works

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

Schuberth, C. E., & Buchberger, A. (2005) · Nature Cell Biology · doi:10.1038/ncb1299 · Cited by 314 · see citing works

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

Ye, Y., Shibata, Y., Kikkert, M., van Voorden, S., Wiertz, E. J. H. J., & Rapoport, T. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505006102 · Cited by 311 · see citing works

Ubx2 links the Cdc48 complex to ER-associated protein degradation

Neuber, O., Jarosch, E., Volkwein, C., Walter, J., & Sommer, T. (2005) · Nature Cell Biology · doi:10.1038/ncb1298 · Cited by 300 · see citing works

Molecular perspectives on p97–VCP: progress in understanding its structure and diverse biological functions

Wang, Q., Song, C., & Li, C.-C. H. (2003) · Journal of Structural Biology · doi:10.1016/j.jsb.2003.11.014 · Cited by 299 · see citing works

Ataxin-3 Interactions with Rad23 and Valosin-Containing Protein and Its Associations with Ubiquitin Chains and the Proteasome Are Consistent with a Role in Ubiquitin-Mediated Proteolysis

Doss-Pepe, E., Stenroos, E. S., Johnson, W. G., & Madura, K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6469-6483.2003 · Cited by 237 · see citing works

Functional Division of Substrate Processing Cofactors of the Ubiquitin-Selective Cdc48 Chaperone

Rumpf, S., & Jentsch, S. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.014 · Cited by 236 · see citing works

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

Rouiller, I., DeLaBarre, B., May, A. P., Weis, W. I., Brünger, A. T., Milligan, R. A., & Kubalek, E. W. (2002) · Nature Structural Biology · doi:10.1038/nsb872 · Cited by 206 · see citing works

Central Pore Residues Mediate the p97/VCP Activity Required for ERAD

DeLaBarre, B., Christianson, J. C., Kopito, R. R., & Brünger, A. T. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.036 · Cited by 204 · see citing works

Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47

Dreveny, I., Kondo, H., Uchiyama, K., Shaw, A., Zhang, X., & Freemont, P. S. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600139 · Cited by 188 · see citing works

Inaugural article : recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

Ye, Y. (2005) · Medical Entomology and Zoology · Cited by 165 · see citing works

Uncoupling retro‐translocation and degradation in the ER‐associated degradation of a soluble protein

Lee, R. J., Liu, C., Harty, C., McCracken, A. A., Latterich, M., Römisch, K., Demartino, G., Thomas, P., & Brodsky, J. L. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600232 · Cited by 113 · see citing works

p97/p47-Mediated Biogenesis of Golgi and ER

Uchiyama, K. (2005) · The Journal of Biochemistry · doi:10.1093/jb/mvi028 · Cited by 110 · see citing works

Going through the motions: The ATPase cycle of p97

Pye, V. E., Dreveny, I., Briggs, L. C., Sands, C. J., Beuron, F., Zhang, X., & Freemont, P. S. (2006) · Journal of Structural Biology · doi:10.1016/j.jsb.2006.03.003 · Cited by 99 · see citing works

Conformational changes in the AAA ATPase p97–p47 adaptor complex

Beuron, F., Dreveny, I., Yuan, X., Pye, V. E., McKeown, C. F., Briggs, L. C., Cliff, M. J., Kaneko, Y., Wallis, R., Isaacson, R. L., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601055 · Cited by 98 · see citing works

Glycoprotein‐specific ubiquitin ligases recognize N‐glycans in unfolded substrates

Yoshida, Y., Adachi, E., Fukiya, K., Iwaï, K., & Tanaka, K. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400351 · Cited by 81 · see citing works

Calcium-sensing Receptor Ubiquitination and Degradation Mediated by the E3 Ubiquitin Ligase Dorfin

Huang, Y. S., Niwa, J., Sobue, G., & Breitwieser, G. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513552200 · Cited by 81 · see citing works

Physical and Functional Interaction between Dorfin and Valosin-containing Protein That Are Colocalized in Ubiquitylated Inclusions in Neurodegenerative Disorders

Ishigaki, S., Hishikawa, N., Niwa, J.-I., Iemura, S.-I., Natsume, T., Hori, S., Kakizuka, A., Tanaka, K., & Sobue, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406683200 · Cited by 76 · see citing works

Alternating translocation of protein substrates from both ends of ClpXP protease

Ortega, J., Lee, H. S., Maurizi, M. R., & Steven, A. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf483 · Cited by 72 · see citing works

Akt-mediated Valosin-containing Protein 97 Phosphorylation Regulates Its Association with Ubiquitinated Proteins

Klein, J. B., Barati, M. T., Wu, R., Gozal, D., Sachleben, L. R., Kausar, H., Trent, J. O., Gozal, E., & Rane, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501802200 · Cited by 66 · see citing works

VAT, the Thermoplasma Homolog of Mammalian p97/VCP, Is an N Domain-regulated Protein Unfoldase

Gerega, A., Rockel, B., Peters, J., Tamura, T., Baumeister, W. P., & Zwickl, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510592200 · Cited by 65 · see citing works

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcı́a-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,726 · see citing works

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Johnson, J. O., Mandrioli, J., Benatar, M., Abramzon, Y., Van Deerlin, V. M., Trojanowski, J. Q., Gibbs, J. R., Brunetti, M., Gronka, S., Wuu, J., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.036 · Cited by 1,235 · see citing works

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration

Lagier-Tourenne, C., Polymenidou, M., & Cleveland, D. W. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq137 · Cited by 1,021 · see citing works

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

Tai, H.-C., & Schuman, E. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2499 · Cited by 532 · see citing works

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

Ju, J.-S., Fuentealba, R. A., Miller, S. E., Jackson, E., Piwnica-Worms, D., Baloh, R. H., & Weihl, C. C. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200908115 · Cited by 494 · see citing works

Exploring the specificity of the PI3K family inhibitor LY294002

Gharbi, S., Zvelebil, M., Shuttleworth, S. J., Hancox, T. C., Saghir, N., Timms, J. F., & Waterfield, M. D. (2007) · Biochemical Journal · doi:10.1042/bj20061489 · Cited by 463 · see citing works

The Ubiquitin–Proteasome System of Saccharomyces cerevisiae

Finley, D. J., Ulrich, H. D., Sommer, T., & Kaiser, P. (2012) · Genetics · doi:10.1534/genetics.112.140467 · Cited by 427 · see citing works

VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling

van den Boom, J., & Meyer, H. H. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.10.028 · Cited by 408 · see citing works

The two faces of protein misfolding: gain‐ and loss‐of‐function in neurodegenerative diseases

Winklhofer, K. F., Tatzelt, J., & Haass, C. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601930 · Cited by 395 · see citing works

The proteasomal system

Jung, T., Catalgol, B., & Grune, T. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.04.001 · Cited by 389 · see citing works

Cdc48 (p97): a ‘molecular gearbox’ in the ubiquitin pathway?

Jentsch, S., & Rumpf, S. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.005 · Cited by 280 · see citing works

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

Ritson, G. P., Custer, S. K., Freibaum, B. D., Guinto, J. B., Geffel, D., Moore, J., Tang, W., Winton, M. J., Neumann, M., Trojanowski, J. Q., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5894-09.2010 · Cited by 256 · see citing works

The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

Xu, S., Peng, G., Wang, Y., Fang, S., & Karbowski, M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-09-0748 · Cited by 243 · see citing works

Valosin-containing protein disease: Inclusion body myopathy with Paget’s disease of the bone and fronto-temporal dementia

Weihl, C. C., Pestronk, A., & Kimonis, V. E. (2009) · Neuromuscular Disorders · doi:10.1016/j.nmd.2009.01.009 · Cited by 236 · see citing works

A Cul3-Based E3 Ligase Removes Aurora B from Mitotic Chromosomes, Regulating Mitotic Progression and Completion of Cytokinesis in Human Cells

Sumara, I., Quadroni, M., Frei, C., Olma, M. H., Sumara, G., Ricci, R., & Peter, M. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.019 · Cited by 230 · see citing works

Cdc48: a power machine in protein degradation

Stolz, A., Hilt, W., Buchberger, A., & Wolf, D. H. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.06.001 · Cited by 226 · see citing works

Regulation of protein turnover by acetyltransferases and deacetylases

Sadoul, K., Boyault, C., Pabion, M., & Khochbin, S. (2007) · Biochimie · doi:10.1016/j.biochi.2007.06.009 · Cited by 223 · see citing works

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone

Custer, S. K., Neumann, M., Lu, H., Wright, A. C., & Taylor, J. P. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq050 · Cited by 204 · see citing works

Autophagy and ALS: mechanistic insights and therapeutic implications

Chua, J. P., De Calbiac, H., Kabashi, E., & Barmada, S. J. (2022) · Autophagy · doi:10.1080/15548627.2021.1926656 · Cited by 189 · see citing works

Cdc48/p97 mediates UV-dependent turnover of RNA Pol II

Verma, R., Oania, R., Fang, R., Smith, G. T., & Deshaies, R. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2010.12.017 · Cited by 196 · see citing works

Recent advances in p97/VCP/Cdc48 cellular functions

Yamanaka, K., Sasagawa, Y., & Ogura, T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.07.001 · Cited by 191 · see citing works

Valosin-containing Protein (p97) Is a Regulator of Endoplasmic Reticulum Stress and of the Degradation of N-End Rule and Ubiquitin-Fusion Degradation Pathway Substrates in Mammalian Cells

Wójcik, C., Rowicka, M., Kudlicki, A. S., Nowis, D., McConnell, E. J., Kujawa, M., & Demartino, G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0432 · Cited by 189 · see citing works

The Cdc48 machine in endoplasmic reticulum associated protein degradation

Wolf, D. H., & Stolz, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.09.002 · Cited by 183 · see citing works

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

Schaeffer, V., Akutsu, M., Olma, M. H., Gomes, L. C., Kawasaki, M., & Đikić, I. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.016 · Cited by 179 · see citing works

CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output

Zheng, H., Huang, S., Wei, G., Sun, Y., Li, C., Si, X., Chen, Y., Tang, Z., Li, X., Chen, Y., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.06.016 · Cited by 148 · see citing works

The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation

Dantuma, N. P., Heinen, C., & Hoogstraten, D. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.01.005 · Cited by 141 · see citing works

Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy

Ju, J.-S., & Weihl, C. C. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq157 · Cited by 141 · see citing works

Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease

Ju, J.-S., Miller, S., Hanson, P. I., & Weihl, C. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805517200 · Cited by 140 · see citing works

WldS requires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration

Avery, M., Sheehan, A. E., Kerr, K. S., Wang, J., & Freeman, M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200808042 · Cited by 158 · see citing works

Cellular functions of NSF: Not just SNAPs and SNAREs

Zhao, C., Slevin, J. T., & Whiteheart, S. W. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.032 · Cited by 136 · see citing works

Protein dislocation from the ER

Bagola, K., Mehnert, M., Jarosch, E., & Sommer, T. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.06.025 · Cited by 126 · see citing works

Autophagy: links with the proteasome

Lamark, T., & Johansen, T. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.002 · Cited by 124 · see citing works

Evidence for a Pro-oxidant Intermediate in the Assembly of Cytochrome Oxidase

Khalimonchuk, O., Bird, A. J., & Winge, D. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702379200 · Cited by 124 · see citing works

EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

Liu, G., Rogers, J. V., Murphy, C. T., & Rongo, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.195 · Cited by 110 · see citing works

Hereditary Inclusion Body Myopathy-Linked p97/VCP Mutations in the NH2 Domain and the D1 Ring Modulate p97/VCP ATPase Activity and D2 Ring Conformation

Halawani, D., LeBlanc, A. C., Rouiller, I., Michnick, S. W., Servant, M. J., & Latterich, M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00252-09 · Cited by 111 · see citing works

Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step

Lee, J. N., Zhang, X., Feramisco, J. D., Gong, Y., & Ye, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806108200 · Cited by 104 · see citing works

Hierarchical Binding of Cofactors to the AAA ATPase p97

Hänzelmann, P., Buchberger, A., & Schindelin, H. (2011) · Structure · doi:10.1016/j.str.2011.03.018 · Cited by 103 · see citing works

Mechanisms of Cdc48/VCP-mediated cell death — from yeast apoptosis to human disease

Braun, R. J., & Zischka, H. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.015 · Cited by 98 · see citing works

Role of p97/VCP (Cdc48) in genome stability

Vaz, B., Halder, S., & Ramadan, K. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00060 · Cited by 91 · see citing works

Forward Genetic Analysis of the Apicomplexan Cell Division Cycle in Toxoplasma gondii

Gubbels, M., Lehmann, M. M., Muthalagi, M., Jerome, M. E., Brooks, C. F., Szatanek, T., Flynn, J., Parrot, B., Radke, J. B., Striepen, B., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040036 · Cited by 92 · see citing works

Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease

Talbot, K., & Ansorge, O. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl202 · Cited by 88 · see citing works

Cdc48pNpl4p/Ufd1p Binds and Segregates Membrane-Anchored/Tethered Complexes via a Polyubiquitin Signal Present on the Anchors

Shcherbik, N., & Haines, D. S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.024 · Cited by 87 · see citing works

VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo

Johnson, A. E., Shu, H., Hauswirth, A. G., Tong, A., & Davis, G. W. (2015) · eLife · doi:10.7554/elife.07366 · Cited by 83 · see citing works

Inhibitors of the AAA+ Chaperone p97

Chapman, E., Maksim, N., de la Cruz, F., & Clair, J. J. L. (2015) · Molecules · doi:10.3390/molecules20023027 · Cited by 82 · see citing works

The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM)

Hänzelmann, P., & Schindelin, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274506 · Cited by 80 · see citing works

Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways

Dargemont, C., & Ossareh‐Nazari, B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.07.011 · Cited by 76 · see citing works

Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases

Clemen, C. S., Tangavelou, K., Strucksberg, K.-H., Just, S., Gaertner, L., Regus‐Leidig, H., Stumpf, M., Reimann, J., Coras, R., Morgan, R. O., et al. (2010) · Brain · doi:10.1093/brain/awq222 · Cited by 75 · see citing works

New ATPase regulators—p97 goes to the PUB

Madsen, L., Seeger, M., Semple, C. A. M., & Hartmann‐Petersen, R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.05.017 · Cited by 72 · see citing works

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

Yin, H., Nalbandian, A., Hsu, C.-I., Li, S., Llewellyn, K. J., Mozaffar, T., Kimonis, V. E., & Weiss, J. H. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.115 · Cited by 72 · see citing works

P97/CDC-48: Proteostasis control in tumor cell biology

Fessart, D., Marza, E., Taouji, S., Delom, F., & Chevet, É. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.05.030 · Cited by 72 · see citing works

Distinct distal myopathy phenotype caused by VCP gene mutation in a Finnish family

Palmio, J., Sandell, S., Suominen, T., Penttilä, S., Raheem, O., Hackman, P., Huovinen, S., Haapasalo, H. K., & Udd, B. (2011) · Neuromuscular Disorders · doi:10.1016/j.nmd.2011.05.008 · Cited by 67 · see citing works

The complexities of p97 function in health and disease

Chapman, E., Fry, A. N., & Kang, M. (2010) · Molecular BioSystems · doi:10.1039/c0mb00176g · Cited by 67 · see citing works

RNA-Seq Profiling of Spinal Cord Motor Neurons from a Presymptomatic SOD1 ALS Mouse

Bandyopadhyay, U., Cotney, J. L., Nagy, M., Oh, S., Leng, J., Mahajan, M. C., Mane, S., Fenton, W. A., Noonan, J. P., & Horwich, A. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053575 · Cited by 64 · see citing works

Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model

Chang, Y., Hung, W.-T., Chang, Y.-C., Chang, H. C., Wu, C., Chiang, A., Jackson, G. R., & Sang, T. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001288 · Cited by 60 · see citing works

UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids

Kim, H., Zhang, H., Meng, D., Russell, G., Lee, J. N., & Ye, J. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m037218 · Cited by 60 · see citing works

Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication

Ramadan, K., Halder, S., Wiseman, K., & Vaz, B. (2016) · Chromosoma · doi:10.1007/s00412-016-0587-4 · Cited by 54 · see citing works

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

Halawani, D., Tessier, S., Anzellotti, D., Bennett, D. A. A., Latterich, M., & LeBlanc, A. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5874-09.2010 · Cited by 53 · see citing works

DOA1/UFD3 Plays a Role in Sorting Ubiquitinated Membrane Proteins into Multivesicular Bodies

Ren, J., Pashkova, N., Winistorfer, S. C., & Piper, R. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802982200 · Cited by 52 · see citing works

Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells

Yoon, S., Cong, W., Bang, Y., Lee, S. N., Yoon, C. S., Kwack, S. J., Kang, T. S., Lee, K. Y., Choi, J., & Choi, H. J. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.04.013 · Cited by 50 · see citing works

GTPase-Mediated Regulation of the Unfolded Protein Response in Caenorhabditis elegans Is Dependent on the AAA+ ATPase CDC-48

Caruso, M.-E., Jenna, S., Bouchecareilh, M., Baillie, D. L., Boismenu, D., Halawani, D., Latterich, M., & Chevet, É. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02252-07 · Cited by 49 · see citing works

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan

Johnson, A. E., Orr, B. O., Fetter, R. D., Moughamian, A. J., Primeaux, L. A., Geier, E. G., Yokoyama, J. S., Miller, B. L., & Davis, G. W. (2021) · Nature Communications · doi:10.1038/s41467-020-20796-8 · Cited by 46 · see citing works

Cysteine String Protein Promotes Proteasomal Degradation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Increasing Its Interaction with the C Terminus of Hsp70-interacting Protein and Promoting CFTR Ubiquitylation

Schmidt, B. Z., Watters, R. J., Aridor, M., & Frizzell, R. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806485200 · Cited by 46 · see citing works

Ubxd1 is a novel co-factor of the human p97 ATPase

Madsen, L., Andersen, K. M., Prag, S., Moos, T., Semple, C. A. M., Seeger, M., & Hartmann‐Petersen, R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.008 · Cited by 45 · see citing works

Valosin Containing Protein Associated Fronto-Temporal Lobar Degeneration: Clinical Presentation, Pathologic Features and Pathogenesis

Weihl, C. C. (2011) · Current Alzheimer Research · doi:10.2174/156720511795563773 · Cited by 44 · see citing works

The Hepatitis B Virus Precore Protein Is Retrotransported from Endoplasmic Reticulum (ER) to Cytosol through the ER-associated Degradation Pathway

Duriez, M., Rossignol, J., & Sitterlin, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807178200 · Cited by 43 · see citing works

Mutations in p97/VCP induce unfolding activity

Rothballer, A., Tzvetkov, N., & Zwickl, P. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.02.031 · Cited by 42 · see citing works

Withaferin A Analogs That Target the AAA+ Chaperone p97

Tao, S., Tillotson, J., Wijeratne, E. M. K., Xu, Y.-M., Kang, M., Wu, T., Lau, E. C., Mesa, C., Mason, D. J., Brown, R. V., et al. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00367 · Cited by 44 · see citing works

Modelling amyotrophic lateral sclerosis in rodents

Todd, T. W., & Petrucelli, L. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00564-x · Cited by 40 · see citing works

Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function

Byun, H., Halani, N., Mertz, J. A., Ali, A. F., Lozano, M. M., & Dudley, J. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004303107 · Cited by 39 · see citing works

Endotoxin Conditioning Induces VCP/p97-mediated and Inducible Nitric-oxide Synthase-dependent Tyr284 Nitration in Protein Phosphatase 2A

Ohama, T., & Brautigan, D. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.099788 · Cited by 40 · see citing works

The molecular pathogenesis of Paget disease of bone

Layfield, R. (2007) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399407000464 · Cited by 39 · see citing works

Signal-Induced Disassembly of the SCF Ubiquitin Ligase Complex by Cdc48/p97

Yen, J. L., Flick, K. M., Papagiannis, C. V., Mathur, R., Tyrrell, A., Ouni, I., Kaake, R. M., Huang, L., & Kaiser, P. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.015 · Cited by 37 · see citing works

Functional characterization of the plant ubiquitin regulatory X (UBX) domain-containing protein AtPUX7 in Arabidopsis thaliana

Gallois, J., Drouaud, J., Lécureuil, A., Guyon‐Debast, A., Bonhomme, S., & Guerche, P. (2013) · Gene · doi:10.1016/j.gene.2013.05.056 · Cited by 37 · see citing works

The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis

Neutzner, A., Li, S., Xu, S., & Karbowski, M. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.03.019 · Cited by 36 · see citing works

Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein

Ikeda, Y., Demartino, G., Brown, M. S., Lee, J. N., Goldstein, J. L., & Ye, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044875 · Cited by 35 · see citing works

Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii

Wijeratne, E. M. K., Gunaherath, G. M. K. B., Chapla, V. M., Tillotson, J., de la Cruz, F., Kang, M., U’Ren, J. M., Araújo, Â. R., Arnold, A. E., Chapman, E., et al. (2016) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00986 · Cited by 33 · see citing works

Interplay between protein homeostasis networks in protein aggregation and proteotoxicity

Douglas, P. M., & Cyr, D. (2009) · Biopolymers · doi:10.1002/bip.21304 · Cited by 31 · see citing works

Three VCP Mutations in Patients with Frontotemporal Dementia

Wong, T. H., Pottier, C. P., Hondius, D., Meeter, L. H. H., van Rooij, J., Melhem, S., bank, T. N. B., van Minkelen, R., van Duijn, C. M., Rozemüller, A. J. M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180301 · Cited by 30 · see citing works

A genome-wide RNAi screen identifies genes regulating the formation of P bodies in C. elegans and their functions in NMD and RNAi

Sun, Y., Yang, P., Zhang, Y., Bao, X., Li, J., Hou, W., Yao, X., Han, J., & Zhang, H. (2011) · Protein & Cell · doi:10.1007/s13238-011-1119-x · Cited by 30 · see citing works

ATP Binding to p97/VCP D1 Domain Regulates Selective Recruitment of Adaptors to Its Proximal N-Domain

Chia, W. S., Xueqi, D. C., Rao, F., Nun, S. B., & Shochat, S. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050490 · Cited by 28 · see citing works

A Cul3-Based E3 Ligase Regulates Mitosis and is Required to Maintain the Spindle Assembly Checkpoint in Human Cells

Sumara, I., & Peter, M. (2007) · Cell Cycle · doi:10.4161/cc.6.24.5068 · Cited by 27 · see citing works

Absence of Aquaporin-4 in Skeletal Muscle Alters Proteins Involved in Bioenergetic Pathways and Calcium Handling

Basco, D., Nicchia, G. P., D’Alessandro, A., Zolla, L., Svelto, M., & Frigeri, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019225 · Cited by 26 · see citing works

Protective Role of Cell Division Cycle 48 (CDC48) Protein against Neurodegeneration via Ubiquitin-Proteasome System Dysfunction during Zebrafish Development

Imamura, S., Yabu, T., & Yamashita, M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.332882 · Cited by 26 · see citing works

WldS, Nmnats and axon degeneration-progress in the past two decades

Feng, Y., Yan, T., He, Z., & Zhai, Q. (2010) · Protein & Cell · doi:10.1007/s13238-010-0021-2 · Cited by 25 · see citing works

Valosin‐containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease

Mori, F., Tanji, K., Toyoshima, Y., Sasaki, H., Yoshida, M., Kakita, A., Takahashi, H., & Wakabayashi, K. (2013) · Neuropathology · doi:10.1111/neup.12050 · Cited by 25 · see citing works

Functional proteomics reveals hepatotoxicity and the molecular mechanisms of different forms of chromium delivered by skin administration

Pan, T., Wang, P., Chen, C., Fang, J., & Sintupisut, N. (2011) · PROTEOMICS · doi:10.1002/pmic.201100055 · Cited by 25 · see citing works

Functional Chromatography Reveals Three Natural Products that Target the Same Protein with Distinct Mechanisms of Action

Kang, M. J., Wu, T., Wijeratne, E. M. K., Lau, E. C., Mason, D. J., Mesa, C., Tillotson, J., Zhang, D. D., Gunatilaka, A. A. L., Clair, J. J. L., et al. (2014) · ChemBioChem · doi:10.1002/cbic.201402258 · Cited by 25 · see citing works

Gene Expression Profiling in Tibial Muscular Dystrophy Reveals Unfolded Protein Response and Altered Autophagy

Screen, M., Raheem, O., Holmlund-Hampf, J., Jonson, P. H., Huovinen, S., Hackman, P., & Udd, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090819 · Cited by 24 · see citing works

Molecular Motor Proteins and Amyotrophic Lateral Sclerosis

Soo, K. Y., Farg, M. A., & Atkin, J. D. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12129057 · Cited by 23 · see citing works

Point-of-care test for cervical cancer in LMICs

Mohammed, S. I., Ren, W., Flowers, L., Rajwa, B. P., Chibwesha, C. J., Parham, G. P., & Irudayaraj, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7709 · Cited by 24 · see citing works

Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses

Setsuie, R., Suzuki, M., Tsuchiya, Y., & Wada, K. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.03.021 · Cited by 23 · see citing works

Functional proteomics reveals the protective effects of saffron ethanolic extract on hepatic ischemia‐reperfusion injury

Pan, T., Wu, T., Wang, P., Leu, Y., Sintupisut, N., Huang, C., Chang, F., & Wu, Y. (2013) · PROTEOMICS · doi:10.1002/pmic.201200551 · Cited by 23 · see citing works

The NRF2-p97-NRF2 negative feedback loop

Shakya, A., Liu, P., Godek, J., McKee, N. W., Dodson, M. B., Anandhan, A., Ooi, A., Garcia, J. G. N., Costa, M., Chapman, E., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102839 · Cited by 22 · see citing works

The Final Moments of Misfolded Proteins en Route to the Proteasome

Zhang, T., & Ye, Y. (2014) · DNA and Cell Biology · doi:10.1089/dna.2014.2452 · Cited by 22 · see citing works

Establishment of an In Vitro Transport Assay That Reveals Mechanistic Differences in Cytosolic Events Controlling Cholera Toxin and T-Cell Receptor α Retro-Translocation

Moore, P. C., He, K., & Tsai, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075801 · Cited by 19 · see citing works

Interaction between Salt-inducible Kinase 2 (SIK2) and p97/Valosin-containing Protein (VCP) Regulates Endoplasmic Reticulum (ER)-associated Protein Degradation in Mammalian Cells

Yang, F.-C., Lin, Y.-H., Chen, W., Huang, J., Chang, H.-Y., Su, S.-H., Wang, H.-T., Chiang, C.-Y., Hsu, P., Tsai, M., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.492199 · Cited by 19 · see citing works

Proteomic Profiling of a Mouse Model for Ovarian Granulosa Cell Tumor Identifies VCP as a Highly Sensitive Serum Tumor Marker in Several Human Cancers

Laguë, M.-N., Romieu, R., Bonneil, É., Boyer, A., Pouletty, N., Mes‐Masson, A., Thibault, P., Nadeau, M., & Boerboom, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042470 · Cited by 18 · see citing works

UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP

Teng, Y., Rezvani, K. S., & Biasi, M. D. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.08.084 · Cited by 17 · see citing works

Cardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function

Viswanathan, M., Blice‐Baum, A. C., Sang, T., & Cammarato, A. (2016) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd3020019 · Cited by 17 · see citing works

Looking for protein expression signatures in European eel peripheral blood mononuclear cells after in vivo exposure to perfluorooctane sulfonate and a real world field study

Roland, K., Kestemont, P., Loos, R., Tavazzi, S., Paracchini, B., Belpaire, C., Dieu, M., Raes, M. J., & Silvestre, F. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.07.110 · Cited by 16 · see citing works

Molecular Mechanism of Processing Ubiquitinated Substrates by p97 and Its Main CofactorsPreprint

Mirzadeh, A., Kazemi, M., & Rouiller, I. (2024) · Preprints.org · doi:10.20944/preprints202409.1194.v1

Characterization of Adaptor Binding and Substrate Processing by VCP/p97

Blythe, E. E. (2019) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/9k4m-0c48

C O MMENT A R Y Open Access

Meyer, H. H. (2012)

New ATPase regulators—p97 goes to the PUB

Madsen, L., Seeger, M., Semple, C. A. M., & Hartmann‐Petersen, R. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.05.017 · Cited by 72 · see citing works

Insights into adaptor binding to the AAA protein p97

Yeung, H. O., Kloppsteck, P., Niwa, H., Isaacson, R. L., Matthews, S., Zhang, X., & Freemont, P. S. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360062 · Cited by 139 · see citing works