The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 4×
“The importance of its transcriptional activity is underscored by the fact that most tumor-associated p53 mutationsoccurwithinitscentralcoredomainresponsible for sequence-specific DNA binding ( Vogelstein etal., 2000 ).”
BackgroundInfluentialLane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,551
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,108 · cited 3×
“In addition, p53 also transactivatesthemdm2genetoinitiatethep53-Mdm2feedback loop, which is crucial for restraining p53 function during the stress response (Michael and Oren, 2002; Brooks and Gu, 2006 ).”
BackgroundInfluentialAcetylation and deacetylation of non-histone proteins
Glozak, M. A., Sengupta, N., Zhang, X., & Seto, E. (2005) · Gene · doi:10.1016/j.gene.2005.09.010 · Cited by 1,584
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327
DNA damage activates p53 through a phosphorylation–acetylation cascade
Sakaguchi, K., Herrera, J. E., Saito, S., Miki, T., Bustin, M., Vassilev, A., Anderson, C. W., & Appella, E. (1998) · Genes & Development · doi:10.1101/gad.12.18.2831 · Cited by 1,204
p53 ubiquitination: Mdm2 and beyond
Brooks, C. L., & Gu, W. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.020 · Cited by 924
Self-citationp53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage
Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., & Berger, S. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1202 · Cited by 776
Murr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613
Research works printed but not linked: 56
- Appella, 2001, Post-translational modifications and activation of p53 by genotoxic stresses, Eur. J. Biochem., 268, 2764, 10.1046/j.1432-1327.2001.02225.x · DOI · Paper page
- Avantaggiati, 1997, Recruitment of p300/CBP in p53-dependent signal pathways, Cell, 89, 1175, 10.1016/S0092-8674(00)80304-9 · DOI · Paper page
- Barlev, 2001, Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases, Mol. Cell, 8, 1243, 10.1016/S1097-2765(01)00414-2 · DOI · Paper page
- Berns, 2004, A large-scale RNAi screen in human cells identifies new components of the p53 pathway, Nature, 428, 431, 10.1038/nature02371 · DOI · Paper page
- Brodsky, 2000, Drosophila p53 binds a damage response element at the reaper locus, Cell, 101, 103, 10.1016/S0092-8674(00)80627-3 · DOI · Paper page
- Brooks, 2003, Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation, Curr. Opin. Cell Biol., 15, 164, 10.1016/S0955-0674(03)00003-6 · DOI · Paper page
- Chuikov, 2004, Regulation of p53 activity through lysine methylation, Nature, 432, 353, 10.1038/nature03117 · DOI · Paper page
- Deissler, 2004, Spectrum of p53 mutations in biopsies from breast cancer patients selected for preoperative chemotherapy analysed by the functional yeast assay to predict therapeutic response, Oncol. Rep., 11, 1281
- el-Deiry, 1993, WAF1, a potential mediator of p53 tumor suppression, Cell, 75, 817, 10.1016/0092-8674(93)90500-P · DOI · Paper page
- Gu, 1997, Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain, Cell, 90, 595, 10.1016/S0092-8674(00)80521-8 · DOI · Paper page
- Gu, 1997, Synergistic activation of transcription by CBP and p53, Nature, 387, 819, 10.1038/42972 · DOI · Paper page
- Hainaut, 2000, p53 and human cancer: the first ten thousand mutations, Adv. Cancer Res., 77, 81, 10.1016/S0065-230X(08)60785-X · DOI · Paper page
- Hashimoto, 1999, p53 null mutations undetected by immunohistochemical staining predict a poor outcome with early-stage non-small cell lung carcinomas, Cancer Res., 59, 5572
- Hayes, 1999, High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors, Brain Pathol., 9, 463, 10.1111/j.1750-3639.1999.tb00535.x · DOI
- Hussain, 1999, p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer, Mutat. Res., 428, 23, 10.1016/S1383-5742(99)00028-9 · DOI · Paper page
- Huyen, 2004, Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1, Structure, 12, 1237, 10.1016/j.str.2004.05.007 · DOI
- Ikura, 2000, Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis, Cell, 102, 463, 10.1016/S0092-8674(00)00051-9 · DOI · Paper page
- Ito, 2001, p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2, EMBO J., 20, 1331, 10.1093/emboj/20.6.1331 · DOI · Paper page
- Jeffers, 2003, Puma is an essential mediator of p53-dependent and -independent apoptotic pathways, Cancer Cell, 4, 321, 10.1016/S1535-6108(03)00244-7 · DOI · Paper page
- Kamine, 1996, Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator, Virology, 216, 357, 10.1006/viro.1996.0071 · DOI · Paper page
- Kern, 1992, Oncogenic forms of p53 inhibit p53-regulated gene expression, Science, 256, 827, 10.1126/science.1589764 · DOI · Paper page
- Krummel, 2005, The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation, Proc. Natl. Acad. Sci. USA, 102, 10188, 10.1073/pnas.0503068102 · DOI · Paper page
- Kusch, 2004, Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions, Science, 306, 2084, 10.1126/science.1103455 · DOI · Paper page
- Legube, 2002, Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation, EMBO J., 21, 1704, 10.1093/emboj/21.7.1704 · DOI
- Legube, 2004, Role of the histone acetyl transferase Tip60 in the p53 pathway, J. Biol. Chem., 279, 44825, 10.1074/jbc.M407478200 · DOI
- Leitao, 2004, Mutation and expression of the TP53 gene in early stage epithelial ovarian carcinoma, Gynecol. Oncol., 93, 301, 10.1016/j.ygyno.2004.01.043 · DOI
- Leu, 2004, Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex, Nat. Cell Biol., 6, 443, 10.1038/ncb1123 · DOI · Paper page
- Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
- Li, 2002, Acetylation of p53 inhibits its ubiquitination by Mdm2, J. Biol. Chem., 277, 50607, 10.1074/jbc.C200578200 · DOI · Paper page
- Lill, 1997, Binding and modulation of p53 by p300/CBP coactivators, Nature, 387, 823, 10.1038/42981 · DOI · Paper page
- Luo, 2000, Deacetylation of p53 modulates its effect on cell growth and apoptosis, Nature, 408, 377, 10.1038/35042612 · DOI · Paper page
- Luo, 2001, Negative control of p53 by Sir2alpha promotes cell survival under stress, Cell, 107, 137, 10.1016/S0092-8674(01)00524-4 · DOI · Paper page
- Luo, 2004, Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo, Proc. Natl. Acad. Sci. USA, 101, 2259, 10.1073/pnas.0308762101 · DOI · Paper page
- Manfredi, 2003, p53 and apoptosis: it's not just in the nucleus anymore, Mol. Cell, 11, 552, 10.1016/S1097-2765(03)00106-0 · DOI
- Meyers, 1993, p53 mutations in benign prostatic hyperplasia, J. Natl. Cancer Inst., 85, 1856, 10.1093/jnci/85.22.1856 · DOI
- Michael, 2002, The p53 and Mdm2 families in cancer, Curr. Opin. Genet. Dev., 12, 53, 10.1016/S0959-437X(01)00264-7 · DOI · Paper page
- Mihara, 2003, p53 has a direct apoptogenic role at the mitochondria, Mol. Cell, 11, 577, 10.1016/S1097-2765(03)00050-9 · DOI · Paper page
- Nakano, 2001, PUMA, a novel proapoptotic gene, is induced by p53, Mol. Cell, 7, 683, 10.1016/S1097-2765(01)00214-3 · DOI · Paper page
- Ollmann, 2000, Drosophila p53 is a structural and functional homolog of the tumor suppressor p53, Cell, 101, 91, 10.1016/S0092-8674(00)80626-1 · DOI · Paper page
- Prives, 1999, The p53 pathway, J. Pathol., 187, 112, 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3 · doi:10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3
- Robert, 2006, The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair, Mol. Cell. Biol., 26, 402, 10.1128/MCB.26.2.402-412.2006 · DOI
- Rodriguez, 1999, SUMO-1 modification activates the transcriptional response of p53, EMBO J., 18, 6455, 10.1093/emboj/18.22.6455 · DOI · Paper page
- Sachchidanand, 2006, Target structure-based discovery of small molecules that block human p53 and CREB binding protein association, Chem. Biol., 13, 81, 10.1016/j.chembiol.2005.10.014 · DOI
- Schumacher, 2001, The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis, Curr. Biol., 11, 1722, 10.1016/S0960-9822(01)00534-6 · DOI · Paper page
- Seoane, 2002, Myc suppression of the p21 cdk inhibitor influences the outcome of the p53 response to DNA damage, Nature, 419, 729, 10.1038/nature01119 · DOI · Paper page
- Tyteca, 2006, Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycleprogression, EMBO J., 25, 1680, 10.1038/sj.emboj.7601066 · DOI
- Vousden, 2002, Live or let die: the cell's response to p53, Nat. Rev. Cancer, 2, 594, 10.1038/nrc864 · DOI · Paper page
- Wang, 2003, Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305, J. Biol. Chem., 278, 25568, 10.1074/jbc.M212574200 · DOI · Paper page
- Wiederschain, 2005, Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage, J. Biol. Chem., 280, 24315, 10.1074/jbc.M412237200 · DOI
- Wu, 2005, Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma, Cell, 123, 641, 10.1016/j.cell.2005.09.029 · DOI · Paper page
- Xirodimas, 2004, Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity, Cell, 118, 83, 10.1016/j.cell.2004.06.016 · DOI · Paper page
- Yang, 2004, The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases, Nucleic Acids Res., 32, 959, 10.1093/nar/gkh252 · DOI · Paper page
- Yu, 2003, PUMA mediates the apoptotic response to p53 in colorectal cancer cells, Proc. Natl. Acad. Sci. USA, 100, 1931, 10.1073/pnas.2627984100 · DOI · Paper page
- Yu, 2005, The transcriptional targets of p53 in apoptosis control, Biochem. Biophys. Res. Commun., 331, 851, 10.1016/j.bbrc.2005.03.189 · DOI · Paper page
- Yu, 2001, PUMA induces the rapid apoptosis of colorectal cancer cells, Mol. Cell, 7, 673, 10.1016/S1097-2765(01)00213-1 · DOI · Paper page
- Zhao, 2006, Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21Waf1/Cip1, Mol. Cell. Biol., 26, 2782, 10.1128/MCB.26.7.2782-2790.2006 · DOI · Paper page
Cited by
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Kruse, J.-P., & Gu, W. (2009) · Cell · doi:10.1016/j.cell.2009.04.050 · Cited by 1,610
Self-citationThe Cell–Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Chen, J. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026104 · Cited by 1,222
Functions and mechanisms of non-histone protein acetylation
Narita, T., Weinert, B. T., & Choudhary, C. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0081-3 · Cited by 1,232
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
Metadata
- Authors
- Tang, Y., Luo, J., Zhang, W., & Gu, W.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 24
- Issue
- 6
- Pages
- 827-839
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1982545065
- Cited by
- 727
- References
- 12
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2456 d)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis. https://app.cochat.ai/papers/10.1016/j.molcel.2006.11.021
- The paper
- Tang, Y., Luo, J., Zhang, W., & Gu, W. (2006). Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis. Molecular Cell. https://doi.org/10.1016/j.molcel.2006.11.021
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.