The Cell–Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

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Transcriptional control of human p53-regulated genes

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Restoration of p53 function leads to tumour regression in vivo

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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Reversal of human cellular senescence: roles of the p53 and p16 pathways

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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The coordinate regulation of the p53 and mTOR pathways in cells

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p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

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The antioxidant function of the p53 tumor suppressor

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A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy

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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

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Function and structure of inherently disordered proteins

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Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest

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Molecular Signals of Epigenetic States

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Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

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Death Signal-induced Localization of p53 Protein to Mitochondria

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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p53-Dependent apoptosis suppresses tumor growth and progression in vivo

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Acetylation Is Indispensable for p53 Activation

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p53 and E2F-1 cooperate to mediate apoptosis.

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Bypass of Senescence After Disruption of p21 ^{<i>CIP1/WAF1</i>} Gene in Normal Diploid Human Fibroblasts

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p53 Dynamics Control Cell Fate

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Mitochondrial p53 activates Bak and causes disruption of a Bak–Mcl1 complex

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Acetylation of the p53 DNA-binding domain regulates apoptosis induction.

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p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

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Tip60-Dependent Acetylation of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis

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Drugging the p53 pathway: understanding the route to clinical efficacy

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

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A p53-Dependent Mouse Spindle Checkpoint

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Inactivation of the p53 pathway in retinoblastoma

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Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

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Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

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PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53

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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

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Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance

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Rapamycin decelerates cellular senescence

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Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

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iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

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MDM4 is a key therapeutic target in cutaneous melanoma

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Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

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Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage

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DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage

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p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

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MDM2 Promotes Proteasome-Dependent Ubiquitin-Independent Degradation of Retinoblastoma Protein

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Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress

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Paradoxical suppression of cellular senescence by p53

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Transgenic mice with p53‐responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

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iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo

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WT p53, but Not Tumor-derived Mutants, Bind to Bcl2 via the DNA Binding Domain and Induce Mitochondrial Permeabilization

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p53 in recombination and repair

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Living with death: the evolution of the mitochondrial pathway of apoptosis in animals

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Comparative Binding of p53 to its Promoter and DNA Recognition Elements

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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

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Activation of p53 by MDM2 Antagonists Can Protect Proliferating Cells from Mitotic Inhibitors

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The p53 response to ionising radiation in adult and developing murine tissues.

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Intact p53-Dependent Responses in miR-34–Deficient Mice

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Protein Kinase C δ Regulates Ser46 Phosphorylation of p53 Tumor Suppressor in the Apoptotic Response to DNA Damage

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Kinetics of p53 Binding to Promoter Sites In Vivo

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Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope

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DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms

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The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

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