The DOI matches its Crossref record; 55 of the 59 references it cites were found in a registry or an index.
Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
Open accessAbstract
The p53 tumor suppressor protein is a critical regulator of the cellular response to cancer-initiating insults such as genotoxic stress. In this report, we demonstrate that microRNAs (miRNAs) are important components of the p53 transcriptional network. Global miRNA expression analyses identified a cohort of miRNAs that exhibit p53-dependent upregulation following DNA damage. One such miRNA, miR-34a, is commonly deleted in human cancers and, as shown here, frequently absent in pancreatic cancer cells. Characterization of the miR-34a primary transcript and promoter demonstrates that this miRNA is directly transactivated by p53. Expression of miR-34a causes dramatic reprogramming of gene expression and promotes apoptosis. Much like the known set of p53-regulated genes, miR-34a-responsive genes are highly enriched for those that regulate cell-cycle progression, apoptosis, DNA repair, and angiogenesis. Therefore, it is likely that an important function of miR-34a is the modulation and fine-tuning of the gene expression program initiated by p53.
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“Considering other proteins significantly changed in AsymAD, like TMPO and HNRNPF (Table S2), the genetic interaction network landscape had edges that were consistently supported by changes found in a microarray study which identified transcripts altered downstream of an age-associated overexpressed circulating and brain-resident microRNA, mIR34-a (Chang et al., 2007; Li et al., 2011).”
From A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease (2017) · cites this paper as Chang et al., 2007
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Gentleman R: R: A language for data analysis and graphics
Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Causes and consequences of microRNA dysregulation in cancer
Croce, C. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2634 · Cited by 3,039
The role of MicroRNAs in human cancer
Peng, Y., & Croce, C. M. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.4 · Cited by 2,566
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Lin, S., & Gregory, R. I. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3932 · Cited by 2,169
Metadata
- Authors
- Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., Arking, D. E., Beer, M. A., Maitra, A., & Mendell, J. T.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Mendell, Joshua T.
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 26
- Issue
- 5
- Pages
- 745-752
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC1939978
- OpenAlex
- W2038167014
- Cited by
- 2,010
- References
- 59
- Citations by year
- 2026: 23 · 2025: 37 · 2024: 34 · 2023: 47 · 2022: 54 · 2021: 94 · 2020: 84 · 2019: 89 · 2018: 94 · 2017: 116 · 2016: 121 · 2015: 133 · 2014: 186 · 2013: 159 · 2012: 177
- FWCI
- 45.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Rita Allen Foundation
- Lustgarten Foundation
- Allen Foundation
- National Cancer Institute (R01CA113669, R01CA120185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- miR-34a, p53, DNA damage response, apoptosis, gene expression reprogramming, pancreatic cancer, cell cycle regulation, DNA repair, angiogenesis, tumor suppressor
- MeSH terms
- Base Sequence, DNA Damage, Humans, Pancreatic Neoplasms, Promoter Regions, Genetic, RNA, Neoplasm, Transcriptional Activation, Gene Expression, Tumor Suppressor Protein p53, Apoptosis, MicroRNAs, Cell Line, Tumor
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