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Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
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“One molecular characteristic of senescence in many human cell types is formation of specialized domains of facultative heterochromatin, called senescence-associated heterochromatin foci (SAHF) (Denoyelle et al., 2006; Narita et al., 2003; Zhang et al., 2005).”
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Cited by
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086
“Furthermore, two other secreted factors, PAI-1 and WNT-2, have been implicated in senescence (Kortlever et al., 2006; Ye et al., 2007).”
BackgroundThe essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038
WNT signalling pathways as therapeutic targets in cancer
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Senescence-messaging secretome: SMS-ing cellular stress
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Cellular senescence and its effector programs
Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855
Metadata
- Authors
- Ye, X., Zerlanko, B., Kennedy, A., Banumathy, G., Zhang, R., & Adams, P. D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 27
- Issue
- 2
- Pages
- 183-196
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2023256466
- Cited by
- 228
- References
- 27
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- American Federation for Aging Research
- Leukemia and Lymphoma Society
- National Institutes of Health (CA104429, GM062281)
- U.S. Department of Defense (DAMD17-02-1-0726)
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- The paper
- Ye, X., Zerlanko, B., Kennedy, A., Banumathy, G., Zhang, R., & Adams, P. D. (2007). Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells. Molecular Cell. https://doi.org/10.1016/j.molcel.2007.05.034
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