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Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
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Citations
Cites
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BackgroundInfluentialRb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
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“Consequently, senescence in vivo Mo is thought to contribute to tissue aging, through exhaustion of renewable tissue stem cell populations (Campisi, 2005; Janzen et al., 2006; Krishnamurthy et al., 2006; Molofsky et al., 2006).”
Backgroundp16INK4a induces an age-dependent decline in islet regenerative potential
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“Consequently, senescence in vivo Mo is thought to contribute to tissue aging, through exhaustion of renewable tissue stem cell populations (Campisi, 2005; Janzen et al., 2006; Krishnamurthy et al., 2006; Molofsky et al., 2006).”
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“Consequently, senescence in vivo Mo is thought to contribute to tissue aging, through exhaustion of renewable tissue stem cell populations (Campisi, 2005; Janzen et al., 2006; Krishnamurthy et al., 2006; Molofsky et al., 2006).”
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Self-citationThe DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
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“In addition, SAHF contain increased amounts of HMGA proteins (Funayama et al., 2006; Narita et al., 2006).”
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Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086
“Furthermore, two other secreted factors, PAI-1 and WNT-2, have been implicated in senescence (Kortlever et al., 2006; Ye et al., 2007).”
BackgroundThe essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038
WNT signalling pathways as therapeutic targets in cancer
Anastas, J. N., & Moon, R. T. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3419 · Cited by 1,911
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Cellular senescence and its effector programs
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Metadata
- Authors
- Ye, X., Zerlanko, B., Kennedy, A., Banumathy, G., Zhang, R., & Adams, P. D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 27
- Issue
- 2
- Pages
- 183-196
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2023256466
- Cited by
- 228
- References
- 28
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2208 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- American Federation for Aging Research
- Leukemia and Lymphoma Society
- National Institutes of Health (CA104429, GM062281)
- U.S. Department of Defense (DAMD17-02-1-0726)
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