The DNA Damage Response: Ten Years After

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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PCNA, the Maestro of the Replication Fork

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Molecular mechanism of nucleotide excision repair

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Histone acetyltransferase complexes: one size doesn't fit all

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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

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Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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TopBP1 Activates the ATR-ATRIP Complex

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

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p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

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Regulation of monoubiquitinated PCNA by DUB autocleavage

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A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

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Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

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γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

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Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cellsPreprint

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Homologous repair of DNA damage and tumorigenesis:the BRCA connection

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Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

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Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.Preprint

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UBA domains of DNA damage-inducible proteins interact with ubiquitin.

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Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

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The Chk2 protein kinase

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The Saccharomyces cerevisiae DNA Repair Gene RAD23 Encodes a Nuclear Protein Containing a Ubiquitin-Like Domain Required for Biological Function

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Adaptation of a DNA Replication Checkpoint Response Depends upon Inactivation of Claspin by the Polo-like Kinase

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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

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One Ring to Rule a Superfamily of E3 Ubiquitin Ligases

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DNA Damage Response as an Anti-Cancer Barrier: Damage Threshold and the Concept of 'Conditional Haploinsufficiency'

Bártek, J., Lukas, J., & Bártková, J. (2007) · Cell Cycle · doi:10.4161/cc.6.19.4754 · Cited by 154

Interplay of replication checkpoints and repair proteins at stalled replication forks

Branzei, D., & Foiani, M. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.018 · Cited by 133

Arrested replication fork processing: Interplay between checkpoints and recombination

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Stabilizers and Destabilizers Controlling Cell Cycle Oscillators

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Ubiquitin proteasome system (UPS): what can chromatin do for you?

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Emerging links between the biological clock and the DNA damage response

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The Fanconi Family Adds a Fraternal Twin

Grompe, M., & van de Vrugt, H. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.008 · Cited by 31

A Touching Response to Damage

Petrini, J. H. J. (2007) · Science · doi:10.1126/science.1143700 · Cited by 23

Checkpoint and Coordinated Cellular Responses to DNA Damage

Yang, X. H., & Zou, L. (2006) · Springer eBooks · doi:10.1007/b136684 · Cited by 20

DNA-Damage Control: Claspin Destruction Turns off the Checkpoint

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Hallmarks of Cancer: The Next Generation

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The DNA-damage response in human biology and disease

Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239

Mechanisms of DNA damage, repair, and mutagenesis

Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039

Molecular Cell Perspective The DNA Damage Response: Ten Years After

Harper, J. W., & Elledge, S. J. (2013)

Connecting the Dots: From DNA Damage and Repair to Aging

Pan, M., Li, K., Lin, S., & Hung, W.-C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17050685 · Cited by 73

Cancer-associated defects in the DNA damage response: drivers for malignant transformation and potential therapeutic targets

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DNA Damage Response and Metabolic Reprogramming in Health and Disease

Chatzidoukaki, O., Goulielmaki, E., Schumacher, B., & Garinis, G. A. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.06.018 · Cited by 58

DNA Damage ResponsePreprint

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