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Cited by 255

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

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Goksoy, Esen, Ma, Yan-Qing, Wang, Xiaoxia, Kong, Xiangming, Perera, Dhanuja, Plow, Edward F., Qin, Jun·2008·Molecular Cell
DOI 10.1016/j.molcel.2008.06.011
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Abstract

Summary Activation of heterodimeric (α/β) integrin transmembrane receptors by the 270 kDa cytoskeletal protein talin is essential for many important cell adhesive and physiological responses. A key step in this process involves interaction of phosphotyrosine-binding (PTB) domain in the N-terminal head of talin (talin-H) with integrin β membrane-proximal cytoplasmic tails (β-MP-CTs). Compared to talin-H, intact talin exhibits low potency in inducing integrin activation. Using NMR spectroscopy, we show that the large C-terminal rod domain of talin (talin-R) interacts with talin-H and allosterically restrains talin in a closed conformation. We further demonstrate that talin-R specifically masks a region in talin-PTB where integrin β-MP-CT binds and competes with it for binding to talin-PTB. The inhibitory interaction is disrupted by a constitutively activating mutation (M319A) or by phosphatidylinositol 4,5-bisphosphate, a known talin activator. These data define a distinct autoinhibition mechanism for talin and suggest how it controls integrin activation and cell adhesion.

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Metadata

Authors
Goksoy, E., Ma, Y.-Q., Wang, X., Kong, X., Perera, D., Plow, E. F., & Qin, J.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2008-07
Volume
31
Issue
1
Pages
124-133
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2008.06.011
OpenAlex
W2037419242
Cited by
255
References
57
FWCI
11.43
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation. https://app.cochat.ai/papers/10.1016/j.molcel.2008.06.011
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Goksoy, E., Ma, Y.-Q., Wang, X., Kong, X., Perera, D., Plow, E. F., & Qin, J. (2008). Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.06.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.