The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus
Open accessAbstract
SUMMARY Cell density-dependent gene regulation by quorum-sensing systems has a crucial function in bacterial physiology and pathogenesis. We demonstrate here that the Staphylococcus aureus agr quorum-sensing regulon is divided into (1) control of metabolism and PSM cytolysin genes, which occurs independently of the small regulatory RNA, RNAIII, and (2) RNAIII-dependent control of additional virulence genes. Remarkably, PSM expression was regulated by direct binding of the AgrA response regulator. Our findings suggest that quorum-sensing regulation of PSMs was established before wide-ranging control of virulence was added to the agr regulon, which likely occurred by development of the RNAIII-encoding region around the gene encoding the PSM, δ-toxin. Moreover, the agr regulon in the community-associated methicillin-resistant S. aureus MW2 considerably differed from that previously determined using laboratory strains. By establishing a novel, two-level model of quorum-sensing target gene regulation in S. aureus, our study gives important insight into the evolution of virulence control in this leading human pathogen.
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Gillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046
Self-citationInsights into Mechanisms Used by Staphylococcus aureus to Avoid Destruction by Human Neutrophils
Voyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563
Self-citationPoring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F. R., & Schneewind, O. (2007) · Nature Medicine · doi:10.1038/nm1207-1405 · Cited by 492
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Gómez, M. I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., Cheung, A., & Prince, A. (2004) · Nature Medicine · doi:10.1038/nm1079 · Cited by 412
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Self-citationPersistent bacterial infections and persister cells
Fisher, R. A., Gollan, B., & Helaine, S. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.42 · Cited by 1,243
Arciola, C. R., Campoccia, D., Speziale, P., Montanaro, L., & Costerton, J. W. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.05.031 · Cited by 1,047
How Staphylococcus aureus biofilms develop their characteristic structure
Periasamy, S., Joo, H.-S., Duong, A. C., Bach, T.-H. L., Tan, V. Y., Chatterjee, S. S., Cheung, G. Y. C., & Otto, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115006109 · Cited by 640
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“Transcription of all three operons is under the control of the accessory gene regulator (Agr) system (Queck et al. 2008).”
Background
Metadata
- Authors
- Queck, S. Y., Jameson-Lee, M., Villaruz, A. E., Bach, T.-H. L., Khan, B. A., Sturdevant, D. E., Ricklefs, S. M., Li, M., & Otto, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 32
- Issue
- 1
- Pages
- 150-158
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2065737889
- Cited by
- 595
- References
- 5
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus. https://app.cochat.ai/papers/10.1016/j.molcel.2008.08.005
- The paper
- Queck, S. Y., Jameson-Lee, M., Villaruz, A. E., Bach, T.-H. L., Khan, B. A., Sturdevant, D. E., Ricklefs, S. M., Li, M., & Otto, M. (2008). RNAIII-Independent Target Gene Control by the agr Quorum-Sensing System: Insight into the Evolution of Virulence Regulation in Staphylococcus aureus. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.08.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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