Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress

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Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

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Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

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Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

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Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

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Genetic and epigenetic regulation of the NRF2-KEAP1 pathway in human lung cancer

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The molecular biology and therapeutic potential of Nrf2 in leukemia

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p21 as a Transcriptional Co-Repressor of S-Phase and Mitotic Control Genes

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p38 MAPK-Mediated Bmi-1 Down-Regulation and Defective Proliferation in ATM-Deficient Neural Stem Cells Can Be Restored by Akt Activation

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p53 attenuates acetaminophen-induced hepatotoxicity by regulating drug-metabolizing enzymes and transporter expression

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SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride

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Obacunone activates the Nrf2-dependent antioxidant responses

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NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response

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NRF2‐dependent stress defense in tumor antioxidant control and immune evasion

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Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway

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Nrf2 Is a Potential Modulator for Orchestrating Iron Homeostasis and Redox Balance in Cancer Cells

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Mitochondrial mechanisms in Treg cell regulation: Implications for immunotherapy and disease treatment

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Identification and Functional Studies of a New Nrf2 Partner IQGAP1: A Critical Role in the Stability and Transactivation of Nrf2

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Proteome Stability as a Key Factor of Genome Integrity

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Autophagy is involved in the protective effect of p21 on LPS-induced cardiac dysfunction

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Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies

Farkhondeh, T., Pourbagher‐Shahri, A. M., Azimi–Nezhad, M., Forouzanfar, F., Brockmueller, A., Ashrafizadeh, M., Talebi, M., Shakibaei, M., & Samarghandian, S. (2021) · Molecules · doi:10.3390/molecules26113157 · Cited by 44

Vitamin E supplementation and mammalian lifespan

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AKAP1/PKA-mediated GRP75 phosphorylation at mitochondria-associated endoplasmic reticulum membranes protects cancer cells against ferroptosis

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Modeling the Dynamic AMD-Associated Chronic Oxidative Stress Changes in Human ESC and iPSC-Derived RPE Cells

Garcia, T. Y., Gutierrez, M. A., Reynolds, J. C., & Lamba, D. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17251 · Cited by 40

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure

Bischoff, L. J. M., Kuijper, I. A., Schimming, J. P., Wolters, L., ter Braak, B., Langenberg, J. P., Noort, D., Beltman, J. B., & van de Water, B. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2353-2 · Cited by 40

Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure

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Human GTSE-1 Regulates p21CIP1/WAF1 Stability Conferring Resistance to Paclitaxel Treatment

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Multiple roles of p53 in cancer development: Regulation of tumor microenvironment, m6A modification and diverse cell death mechanisms

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Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2

Maiuthed, A., Ninsontia, C., Erlenbach‐Wuensch, K., Ndreshkjana, B., Muenzner, J. K., Caliskan, A., Husayn, A. P., Chaotham, C., Hartmann, A., Roehe, A. V., et al. (2018) · Cancers · doi:10.3390/cancers10100373 · Cited by 39

Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans

Chun, K., Raut, P. K., Kim, D., & Surh, Y. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.031 · Cited by 37

The dual role of p62 in ferroptosis of glioblastoma according to p53 status

Yuan, F., Sun, Q., Zhang, S., Ye, L., Xu, Y., Deng, G., Xu, Z., Zhang, S., Liu, B., & Chen, Q. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00764-z · Cited by 39

Harmine prevents 3-nitropropionic acid-induced neurotoxicity in rats via enhancing NRF2-mediated signaling: Involvement of p21 and AMPK

Habib, M. Z., Tadros, M. G., Abd-Alkhalek, H. A., Mohamad, M. I., Eid, D., Hassan, F. E., Elhelaly, H. M., el Faramawy, Y., & Aboul‐Fotouh, S. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175046 · Cited by 38

Role of Reactive Oxygen Species in Estrogen Dependant Breast Cancer Complication

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Implications of Epigenetic Mechanisms and their Targets in Cerebral Ischemia Models

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CDCA2 protects against oxidative stress by promoting BRCA1–NRF2 signaling in hepatocellular carcinoma

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Ketogenesis controls mitochondrial gene expression and rescues mitochondrial bioenergetics after cervical spinal cord injury in rats

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Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer

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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

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Developmental Arrest of T Cells in Rpl22-Deficient Mice Is Dependent upon Multiple p53 Effectors

Stadanlick, J. E., Zhang, Z., Lee, S.-Y., Hemann, M., Biery, M. C., Carleton, M. O., Zambetti, G. P., Anderson, S. J., Oravecz, T., & Wiest, D. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100029 · Cited by 36

Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21CIP1/WAF1 in the liver

Yeganeh, M., Gui, Y., Kandhi, R., Bobbala, D., Tobelaim, W.-S., Saucier, C., Yoshimura, A., Ferbeyre, G., Ramanathan, S., & Ilangumaran, S. (2016) · Oncogene · doi:10.1038/onc.2015.485 · Cited by 40

Dietary Flavonoids in p53—Mediated Immune Dysfunctions Linking to Cancer Prevention

Siddiqui, S. S., Rahman, S., Rupasinghe, H. P. V., & Vazhappilly, C. G. (2020) · Biomedicines · doi:10.3390/biomedicines8080286 · Cited by 36

The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer

Fakheri, H., Sajadi, M. A., Afrashteh, A., Ma, W., Xia, L., & Valilo, M. (2023) · Biochemia Medica · doi:10.11613/bm.2023.030504 · Cited by 40

Sporadic activation of an oxidative stress–dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies

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Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells

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Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B

Lee, K.-M., Kang, K., Lee, S. B., & Nho, C. W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.053 · Cited by 36

Fetal origin confers radioresistance on liver macrophages via p21

Soysa, R., Lampert, S., Yuen, S. Y., Douglass, A. N., Li, W., Pfeffer, K., & Crispe, I. N. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.015 · Cited by 37

Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression

Kim, S., Saeidi, S., Cho, N., Kim, S. H., Lee, H., Han, W., Noh, D., & Surh, Y. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.047 · Cited by 35

NRF2 Regulation by Noncoding RNAs in Cancers: The Present Knowledge and the Way Forward

Fabrizio, F. P., Sparaneo, A., & Muscarella, L. A. (2020) · Cancers · doi:10.3390/cancers12123621 · Cited by 36

Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice

Iketani, M., Sekimoto, K., Igarashi, T., Takahashi, M. M., Komatsu, M., Sakane, I., Takahashi, H., Kawaguchi, H., Ohtani‐Kaneko, R., & Ohsawa, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-35239-0 · Cited by 35

Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer

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Sulforaphane inhibits PDGF-induced proliferation of rat aortic vascular smooth muscle cell by up-regulation of p53 leading to G1/S cell cycle arrest

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A role for p53 in mitochondrial stress response control of longevity in C. elegans

Torgovnick, A., Schiavi, A., Testi, R., & Ventura, N. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.02.007 · Cited by 33

The Guardian Recruits Cops: The p53-p21 Axis Delegates Prosurvival Duties to the Keap1-Nrf2 Stress Pathway

Tolédano, M. B. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.005 · Cited by 33

The mechanistic insights of the antioxidant Keap1-Nrf2 pathway in oncogenesis: a deadly scenario

Mukherjee, A. G., & Gopalakrishnan, A. V. (2023) · Medical Oncology · doi:10.1007/s12032-023-02124-4 · Cited by 33

Administration of low dose methamphetamine 12 h after a severe traumatic brain injury prevents neurological dysfunction and cognitive impairment in rats.

Rau, T. F., Kothiwal, A., Rova, A. R., Brooks, D. M., Rhoderick, J. F., Poulsen, A., Hutchinson, J., & Poulsen, D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.001 · Cited by 34

Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips

Snouber, L. C., Jacques, S., Monge, M., Legallais, C., & Leclerc, É. (2012) · Genomics · doi:10.1016/j.ygeno.2012.05.001 · Cited by 32

Nonhematopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice

Ghosh, S., Ihunnah, C. A., Hazra, R., Walker, A. L., Hansen, J. M., Archer, D. R., Owusu-Ansah, A. T., & Ofori-Acquah, S. F. (2016) · JCI Insight · doi:10.1172/jci.insight.81090 · Cited by 33

Importance of the Keap1-Nrf2 pathway in NSCLC: Is it a possible biomarker? (Review)

Rodríguez, R. B. (2018) · Biomedical Reports · doi:10.3892/br.2018.1143 · Cited by 32

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status

Garufi, A., Baldari, S., Pettinari, R., Montani, M. S. G., D’Orazi, V., Pistritto, G., Crispini, A., Giorno, E., Toietta, G., Marchetti, F., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01628-5 · Cited by 34

New derivatives of 4′-phenyl-2,2’:6′,2″-terpyridine as promising anticancer agents

Malarz, K., Zych, D., Gawecki, R., Kuczak, M., Musioł, R., & Mrozek‐Wilczkiewicz, A. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.113032 · Cited by 32

Umbilical Cord MSCs Reverse D-Galactose-Induced Hepatic Mitochondrial Dysfunction via Activation of Nrf2/HO-1 Pathway

Yan, W., Li, D., Chen, T., Tian, G., Zhou, P., & Ju, X. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00777 · Cited by 32

Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Hiemstra, S. W., Fehling-Kaschek, M., Kuijper, I. A., Bischoff, L. J. M., Wijaya, L. S., Rosenblatt, M., Esselink, J. J., van Egmond, A., Mos, J., Beltman, J. B., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10857-x · Cited by 31

Nrf2 expression in endometrial serous carcinomas and its precancers.

Chen, N., Yi, X., Abushahin, N., Pang, S., Zhang, D., Kong, B., & Zheng, W. (2010) · PubMed Central · Cited by 31

Amniotic Fluid Stem Cell-Derived Extracellular Vesicles Counteract Steroid-Induced Osteoporosis In Vitro

Gatti, M., Beretti, F., Zavatti, M., Bertucci, E., Luz, S. R., Palumbo, C., & Maraldi, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010038 · Cited by 30

The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study

Garufi, A., Pistritto, G., D’Orazi, V., Cirone, M., & D’Orazi, G. (2022) · Biomolecules · doi:10.3390/biom12030461 · Cited by 29

Nrf2‐lncRNA controls cell fate by modulating p53‐dependent Nrf2 activation as an miRNA sponge for Plk2 and p21 cip1

Joo, M. S., Shin, S., Kim, E., Koo, H. J., Yim, H., & Kim, S. G. (2019) · The FASEB Journal · doi:10.1096/fj.201802744r · Cited by 30

Cullin 3 and Its Role in Tumorigenesis

Chen, R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_12 · Cited by 29

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage

Hiemstra, S. W., Niemeijer, M., Koedoot, E., Wink, S., Klip, J. E., Vlasveld, M., de Zeeuw, E., van Os, B. W., White, A., & van de Water, B. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00322 · Cited by 31

Familial Melanoma–Associated Mutations in p16 Uncouple its Tumor-Suppressor Functions

Jenkins, N., Jung, J., Liu, T., Wilde, M., Holmen, S. L., & Grossman, D. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.401 · Cited by 31

P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis

Carvalho, C. S. C., da Silva, R. D. F., Melo, T. M. V. D. P. E., Inga, A., & Saraiva, L. (2024) · Cancers · doi:10.3390/cancers16233978 · Cited by 32

CDDO and Its Role in Chronic Diseases

Mathis, B. J., & Cui, T. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41342-6_13 · Cited by 28

The Taming of Nuclear Factor Erythroid-2-Related Factor-2 (Nrf2) Deglycation by Fructosamine-3-Kinase (FN3K)-Inhibitors-A Novel Strategy to Combat Cancers

Beeraka, N. M., Bovilla, V. R., Doreswamy, S. H., Puttalingaiah, S., Srinivasan, A., & Madhunapantula, S. V. (2021) · Cancers · doi:10.3390/cancers13020281 · Cited by 28

The antioxidant response in Barrett's tumorigenesis: A double-edged sword

Peng, D., Zaika, A. I., Que, J., & El-Rifai, W. M. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101894 · Cited by 28

Molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain in response to DNA damage

Boda, E., Lorenzati, M., Parolisi, R., Harding, B. N., Pallavicini, G., Bonfanti, L., Moccia, A., Bielas, S. L., Cunto, F. D., & Buffo, A. (2022) · Nature Communications · doi:10.1038/s41467-022-30010-6 · Cited by 31

ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress

Maher, T. J., Ren, Y., Li, Q., Braunlin, E., Garry, M. G., Sorrentino, B. P., & Martin, C. M. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00638.2013 · Cited by 28

Hepatic Transcriptome Responses of Domesticated and Wild Turkey Embryos to Aflatoxin B1

Monson, M. S., Cardona, C. J., Coulombe, R. A., & Reed, K. M. (2016) · Toxins · doi:10.3390/toxins8010016 · Cited by 28

Nrf2-Independent Anti-Inflammatory Effects of Dimethyl Fumarate: Challenges and Prospects in Developing Electrophilic Nrf2 Activators for Neurodegenerative Diseases

Izumi, Y., & Kōyama, Y. (2024) · Antioxidants · doi:10.3390/antiox13121527 · Cited by 31

Peroxiredoxin I plays a protective role against UVA irradiation through reduction of oxidative stress

Ito, T., Kimura, S., Seto, K., Warabi, E., Kawachi, Y., Shoda, J., Tabuchi, K., Yamagata, K., Hasegawa, S., Bukawa, H., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.12.002 · Cited by 27

Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity

Murray, D. L., Mirzayans, R., & McBride, W. H. (2018) · Radiation Research · doi:10.1667/rr15101.1 · Cited by 28

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

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Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells

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Regulation of Cell Proliferation and Nrf2-Mediated Antioxidant Defense: Conservation of Keap1 Cysteines and Nrf2 Binding Site in the Context of the Evolution of KLHL Family

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NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells

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Uncovering metabolism in rhabdomyosarcoma

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A Novel Polyphenol Conjugate Sensitizes Cisplatin-Resistant Head and Neck Cancer Cells to Cisplatin via Nrf2 Inhibition

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Dietary restriction and aging in rodents: a current view on its molecular mechanisms.

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Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers

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Involvement of the p62/Nrf2/HO-1 pathway in the browning effect of irisin in 3T3-L1 adipocytes

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Oleic acid from cancer-associated fibroblast promotes cancer cell stemness by stearoyl-CoA desaturase under glucose-deficient condition

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Mechanisms Underlying Chemopreventive Effects of Flavonoids via Multiple Signaling Nodes within Nrf2-ARE and AhR-XRE Gene Regulatory Networks

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P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway

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Mechanisms and consequences of oxidant-induced renal preconditioning: an Nrf2-dependent, P21-independent, anti-senescence pathway

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Nrf2 mediates the resistance of human A549 and HepG2 cancer cells to boningmycin, a new antitumor antibiotic, in vitro through regulation of glutathione levels

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Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2

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Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints

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Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer

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Protective Effects of L‐Malate against Myocardial Ischemia/Reperfusion Injury in Rats

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Redox maintenance and concerted modulation of gene expression and signaling pathways by a nanoformulation of curcumin protects peripheral blood mononuclear cells against gamma radiation

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HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi’s Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity

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Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies

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Responses of Cultured Human Keratocytes and Myofibroblasts to Ethyl Pyruvate: A Microarray Analysis of Gene Expression

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Nrf2–Keap1 defines a physiologically important stress response mechanism

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Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

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The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response

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Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation

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