The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres
Open accessAbstract
Telomere-repeat encoding RNA (referred to as TERRA) has been identified as a potential component of yeast and mammalian telomeres. We show here that TERRA RNA interacts with several telomere-associated proteins, including telomere repeat factors 1 (TRF1) and 2 (TRF2), subunits of the Origin Recognition Complex (ORC), heterochromatin protein 1 (HP1), histone H3 trimethyl K9 (H3 K9me3), and members of the DNA damage sensing pathway. siRNA depletion of TERRA caused an increase in telomere dysfunction-induced foci (TIF), aberrations in metaphase telomeres, and a loss of histone H3 K9me3 and ORC at telomere repeat DNA. Previous studies found that TRF2 amino-terminal GAR domain recruited ORC to telomeres. We now show that TERRA RNA can interact directly with the TRF2 GAR and ORC1 to form a stable ternary complex. We conclude that TERRA facilitates TRF2 interaction with ORC and plays a central role in telomere structural maintenance and heterochromatin formation.
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Cites
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How Shelterin Protects Mammalian Telomeres
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Blackburn, E. H., Greider, C. W., & Szostak, J. W. (2006) · Nature Medicine · doi:10.1038/nm1006-1133 · Cited by 880
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
Schoeftner, S., & Blasco, M. A. (2008) · Nature Cell Biology · doi:10.1038/ncb1685 · Cited by 791
The Establishment, Inheritance, and Function of Silenced Chromatin in Saccharomyces cerevisiae
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Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Roach, R. J., Garavís, M., González, C., Jameson, G. B., Filichev, V. V., & Hale, T. K. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz1138 · Cited by 518
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 323
Zhu, Y., Liu, X., Ding, X., Wang, F., & Geng, X. (2019) · Biogerontology · doi:10.1007/s10522-018-9769-1 · Cited by 255
Metadata
- Authors
- Deng, Z., Norseen, J., Wiedmer, A., Riethman, H., & Lieberman, P. M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 35
- Issue
- 4
- Pages
- 403-413
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2056487312
- Cited by
- 549
- References
- 34
- FWCI
- 20.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Deng, Z., Norseen, J., Wiedmer, A., Riethman, H., & Lieberman, P. M. (2009). TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.06.025
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