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The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging

Blackburn, Elizabeth H, Greider, Carol W, Szostak, Jack W·2006·Nature Medicine
DOI 10.1038/nm1006-1133
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Crossref · 10.1038/nm1006-1133

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  • Genomic stability systems include specific mechanisms for maintaining the appropriate length and functionality of telomeres and for ensuring the integrity of mitochondrial DNA.

    “The genomic stability systems also include specific mechanisms for maintaining the appropriate length and functionality of telomeres (which are the topic of a separate hallmark, see below), and for ensuring the integrity of mitochondrial DNA (mtDNA) (Blackburn et al., 2006; Kazak et al., 2012).”

    From The Hallmarks of Aging (2013) · cites this paper as Blackburn et al., 2006

  • Accumulation of DNA damage with age appears to affect the genome near-to-randomly, but some chromosomal regions, such as telomeres, are particularly susceptible to age-related deterioration.

    “Accumulation of DNA damage with age appears to affect the genome near-to-randomly, but there are some chromosomal regions, such as telomeres, that are particularly susceptible to age-related deterioration (Blackburn et al., 2006) (Figure 2A).”

    From The Hallmarks of Aging (2013) · cites this paper as Blackburn et al., 2006

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Research works printed but not linked: 42

  1. McClintock, B. Cytological observations of deficiencies involving known genes, translocations and an inversion in Zea mays. Missouri Agr. Exp. Sta. Res. Bull. 163, 1–48 (1931).
  2. Muller, H.J. The remaking of chromosomes. Collecting Net 13, 181–198 (1938).
  3. Kornberg, A. DNA Synthesis (W.H. Freeman, San Francisco, 1974).
  4. Watson, J.D. Origin of concatameric T7 DNA. Nat. New Biol. 239, 197–201 (1972). · DOI · Paper page
  5. Blackburn, E.H. & Szostak, J.W. The molecular structure of centromeres and telomeres. Annu. Rev. Biochem. 53, 163–194 (1984). · DOI
  6. Wu, R. & Taylor, E. Nucleotide sequence analysis of DNA. II. Complete nucleotide sequence of the cohesive ends of bacteriophage lambda DNA. J. Mol. Biol. 57, 491–511 (1971). · DOI
  7. Blackburn, E.H. & Gall, J.G. A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena. J. Mol. Biol. 120, 33–53 (1978). · DOI · Paper page
  8. Yao, M.C., Blackburn, E. & Gall, J.G. Amplification of the rRNA genes in Tetrahymena. Cold Spring Harb. Symp. Quant. Biol. 43, 1293–1296 (1979). · DOI
  9. Yao, M.C., Blackburn, E. & Gall, J. Tandemly repeated C-C-C-C-A-A hexanucleotide of Tetrahymena rDNA is present elsewhere in the genome and may be related to the alteration of the somatic genome. J. Cell Biol. 90, 515–520 (1981). · DOI
  10. Johnson, E.M. A family of inverted repeat sequences and specific single-strand gaps at the termini of the Physarum rDNA palindrome. Cell 22, 875–886 (1980). · DOI
  11. Emery, H.S. & Weiner, A.M. An irregular satellite sequence is found at the termini of the linear extrachromosomal rDNA in Dictyostelium discoideum. Cell 26, 411–419 (1981). · DOI
  12. Blackburn, E.H. et al. DNA termini in ciliate macronuclei. Cold Spring Harb. Symp. Quant. Biol. 47, 1195–1207 (1983). · DOI
  13. Pan, W.C. & Blackburn, E.H. Single extrachromosomal ribosomal RNA gene copies are synthesized during amplification of the rDNA in Tetrahymena. Cell 23, 459–466 (1981). · DOI
  14. Katzen, A.L., Cann, G.M. & Blackburn, E.H. Sequence-specific fragmentation of macronuclear DNA in a holotrichous ciliate. Cell 24, 313–320 (1981). · DOI
  15. Klobutcher, L.A., Swanton, M.T., Donini, P. & Prescott, D.M. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus. Proc. Natl. Acad. Sci. USA 78, 3015–3019 (1981). · DOI
  16. Boswell, R.E., Klobutcher, L.A. & Prescott, D.M. Inverted terminal repeats are added to genes during macronuclear development in Oxytricha nova. Proc. Natl. Acad. Sci. USA 79, 3255–3259 (1982). · DOI
  17. Orr-Weaver, T.L., Szostak, J.W. & Rothstein, R.J. Yeast transformation: a model system for the study of recombination. Proc. Natl. Acad. Sci. USA 78, 6354–6358 (1981). · DOI
  18. Szostak, J.W. & Blackburn, E.H. Cloning yeast telomeres on linear plasmid vectors. Cell 29, 245–255 (1982). · DOI
  19. Murray, A.W. & Szostak, J.W. Construction of artificial chromosomes in yeast. Nature 305, 189–193 (1983). · DOI
  20. Murray, A.W., Schultes, N.P. & Szostak, J.W. Chromosome length controls mitotic chromosome segregation in yeast. Cell 45, 529–536 (1986). · DOI
  21. Dawson, D.S., Murray, A.W. & Szostak, J.W. An alternative pathway for meiotic chromosome segregation in yeast. Science 234, 713–717 (1986). · DOI
  22. Bernards, A., Michels, P.A., Lincke, C.R. & Borst, P. Growth of chromosomal ends in multiplying trypanosomes. Nature 303, 592–597 (1983). · DOI
  23. Walmsley, R.W., Chan, C.S., Tye, B.-K. & Petes, T.D. Unusual DNA sequences associated with the ends of yeast chromosomes. Nature 310, 157–160 (1984). · DOI
  24. Greider, C.W. & Blackburn, E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405–413 (1985). · DOI · Paper page
  25. Lundblad, V. & Szostak, J.W. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57, 633–643 (1989). · DOI
  26. Cohn, M. & Blackburn, E.H. Telomerase in yeast. Science 269, 396–400 (1995). · DOI
  27. Prescott, J. & Blackburn, E.H. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev. 11, 528–540 (1997). · DOI
  28. Lingner, J., Cech, T.R., Hughes, T.R. & Lundblad, V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc. Natl. Acad. Sci. USA 94, 11190–11195 (1997). · DOI
  29. Nugent, C.I. & Lundblad, V. The telomerase reverse transcriptase: components and regulation. Genes Dev. 12, 1073–1085 (1998). · DOI
  30. Lendvay, T.S., Morris, D.K., Sah, J., Balasubramanian, B. & Lundblad, V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144, 1399–1412 (1996). · DOI
  31. Lingner, J. et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561–567 (1997). · DOI · Paper page
  32. Cooke, H.J., Brown, W.R. & Rappold, G.A. Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal. Nature 317, 687–692 (1985). · DOI
  33. Moyzis, R.K. et al. A highly conserved repetitive DNA sequence (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85, 6622–6626 (1988). · DOI
  34. Allshire, R.C. et al. Telomeric repeats from T. thermophila cross hybridize with human telomeres. Nature 332, 656–659 (1988). · DOI
  35. Olovnikov, A.M. A theory of marginotomy. J. Theor. Biol. 41, 181–190 (1973). · DOI
  36. Hastie, N.D. et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866–868 (1990). · DOI · Paper page
  37. Hackett, J.A. & Greider, C.W. Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis. Oncogene 21, 619–626 (2002). · DOI
  38. Chen, J.L., Blasco, M.A. & Greider, C.W. Secondary structure of vertebrate telomerase RNA. Cell 100, 503–514 (2000). · DOI · Paper page
  39. Ruggero, D. et al. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science 299, 259–262 (2003). · DOI
  40. Mitchell, J.R., Wood, E. & Collins, K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402, 551–555 (1999). · DOI · Paper page
  41. Chen, J.L. & Greider, C.W. Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends Biochem. Sci. 29, 183–192 (2004). · DOI
  42. Hao, L.Y. et al. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123, 1121–1131 (2005). · DOI · Paper page

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Metadata

Authors
Blackburn, E. H., Greider, C. W., & Szostak, J. W.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2006-10
Volume
12
Issue
10
Pages
1133-1138
ISSN
  • 1078-8956
  • 1546-170X
DOI
10.1038/nm1006-1133
Cited by
880
References
16
Language
en
Licence
www.springer.com/tdm (tdm)

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