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The epigenetic regulation of mammalian telomeres

Blasco, María A.·2007·Nature Reviews Genetics
DOI 10.1038/nrg2047
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Abstract

Increasing evidence indicates that chromatin modifications are important regulators of mammalian telomeres. Telomeres provide well studied paradigms of heterochromatin formation in yeast and flies, and recent studies have shown that mammalian telomeres and subtelomeric regions are also enriched in epigenetic marks that are characteristic of heterochromatin. Furthermore, the abrogation of master epigenetic regulators, such as histone methyltransferases and DNA methyltransferases, correlates with loss of telomere-length control, and telomere shortening to a critical length affects the epigenetic status of telomeres and subtelomeres. These links between epigenetic status and telomere-length regulation provide important new avenues for understanding processes such as cancer development and ageing, which are characterized by telomere-length defects.

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  • Loss of heterochromatic marks at telomeres leads to telomere lengthening.

    “Of note, loss of heterochromatic marks at telomeres has been shown to lead to telomere lengthening 54 .”

    From Hallmarks of aging: An expanding universe (2023) · cites this paper as [54]

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Metadata

Authors
Blasco, M. A.
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2007-04
Volume
8
Issue
4
Pages
299-309
ISSN
  • 1471-0056
  • 1471-0064
DOI
10.1038/nrg2047
Cited by
600
References
24
Language
en
Licence
www.springer.com/tdm (tdm)

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