The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline
Open accessAbstract
Summary Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe conditional alleles of the dicer-related helicase, drh-3, that abrogate both RNA interference and the biogenesis of endo-siRNAs, called 22G-RNAs. DRH-3 is a core component of RNA-dependent RNA polymerase (RdRP) complexes essential for several distinct 22G-RNA systems. We show that in the germ-line, one system is dependent on worm-specific AGOs, including WAGO-1, which localizes to germ-line nuage structures called P-granules. WAGO-1 silences certain genes, transposons, pseudogenes and cryptic loci. Finally, we demonstrate that components of the nonsense-mediated decay pathway function in at least one WAGO-mediated surveillance pathway. These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest novel regulatory functions for small RNAs.
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Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
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The microRNAs of Caenorhabditis elegans
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Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells
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Self-citationpiRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
Ashe, A., Sapetschnig, A., Weick, E.-M., Mitchell, J., Bagijn, M. P., Cording, A. C., Doebley, A.-L., Goldstein, L. D., Lehrbach, N. J., Le Pen, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.018 · Cited by 754
Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans
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Shen, E.-Z., Chen, H., Ozturk, A. R., Tu, S., Shirayama, M., Tang, W., Ding, Y.-H., Dai, S.-Y., Weng, Z., & Mello, C. C. (2018) · Cell · doi:10.1016/j.cell.2018.02.002 · Cited by 226
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Metadata
- Authors
- Gu, W., Shirayama, M., Conte, D., Vasale, J., Batista, P. J., Claycomb, J. M., Moresco, J. J., Youngman, E. M., Keys, J., Stoltz, M. J., Chen, C.-C. G., Chaves, D. A., Duan, S., Kasschau, K. D., Fahlgren, N., Yates, J. R., Mitani, S., Carrington, J. C., & Mello, C. C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 36
- Issue
- 2
- Pages
- 231-244
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1995048848
- Cited by
- 505
- References
- 4
- FWCI
- 10.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gu, W., Shirayama, M., Conte, D., Vasale, J., Batista, P. J., Claycomb, J. M., Moresco, J. J., Youngman, E. M., Keys, J., Stoltz, M. J., Chen, C.-C. G., Chaves, D. A., Duan, S., Kasschau, K. D., Fahlgren, N., Yates, J. R., Mitani, S., Carrington, J. C., & Mello, C. C. (2009). Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.09.020
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