Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 775

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

Open access
Haas, Tobias L., Emmerich, Christoph H., Gerlach, Björn, Schmukle, Anna C., Cordier, Stefanie M., Rieser, Eva, Feltham, Rebecca, Vince, James, Warnken, Uwe, Wenger, Till, Koschny, Ronald, Komander, David, Silke, John, Walczak, Henning·2009·Molecular Cell
DOI 10.1016/j.molcel.2009.10.013
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molcel.2009.10.013

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 6 references

Research works printed but not linked: 57

  1. Beckett, 1999, A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation, Protein Sci., 8, 921, 10.1110/ps.8.4.921 · DOI · Paper page
  2. Bertrand, 2008, cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination, Mol. Cell, 30, 689, 10.1016/j.molcel.2008.05.014 · DOI · Paper page
  3. Blankenship, 2009, Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1), Biochem. J., 417, 149, 10.1042/BJ20081885 · DOI
  4. Bloor, 2008, Signal processing by its coil zipper domain activates IKK gamma, Proc. Natl. Acad. Sci. USA, 105, 1279, 10.1073/pnas.0706552105 · DOI
  5. Chen, 2002, TNF-R1 signaling: a beautiful pathway, Science, 296, 1634, 10.1126/science.1071924 · DOI · Paper page
  6. Chen, 2009, Nonproteolytic functions of ubiquitin in cell signaling, Mol. Cell, 33, 275, 10.1016/j.molcel.2009.01.014 · DOI · Paper page
  7. Cossu, 2009, Structural basis for bivalent smac-mimetics recognition in the IAP protein family, J. Mol. Biol., 392, 630, 10.1016/j.jmb.2009.04.033 · DOI
  8. Devin, 2000, The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation, Immunity, 12, 419, 10.1016/S1074-7613(00)80194-6 · DOI · Paper page
  9. Diessenbacher, 2008, NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2, J. Invest. Dermatol., 128, 1134, 10.1038/sj.jid.5701141 · DOI
  10. Ea, 2006, Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO, Mol. Cell, 22, 245, 10.1016/j.molcel.2006.03.026 · DOI · Paper page
  11. Ermolaeva, 2008, Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses, Nat. Immunol., 9, 1037, 10.1038/ni.1638 · DOI · Paper page
  12. Gyrd-Hansen, 2008, IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis, Nat. Cell Biol., 10, 1309, 10.1038/ncb1789 · DOI · Paper page
  13. Hayden, 2008, Shared principles in NF-kappaB signaling, Cell, 132, 344, 10.1016/j.cell.2008.01.020 · DOI · Paper page
  14. Hitotsumatsu, 2008, The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals, Immunity, 28, 381, 10.1016/j.immuni.2008.02.002 · DOI · Paper page
  15. Hoeller, 2006, Ubiquitin and ubiquitin-like proteins in cancer pathogenesis, Nat. Rev. Cancer, 6, 776, 10.1038/nrc1994 · DOI · Paper page
  16. Hsu, 1995, The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation, Cell, 81, 495, 10.1016/0092-8674(95)90070-5 · DOI · Paper page
  17. Ikeda, 2008, Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ review series, EMBO Rep., 9, 536, 10.1038/embor.2008.93 · DOI · Paper page
  18. Iwai, 2009, Linear polyubiquitination: a new regulator of NF-kappaB activation, EMBO Rep., 10, 706, 10.1038/embor.2009.144 · DOI
  19. Kanayama, 2004, TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains, Mol. Cell, 15, 535, 10.1016/j.molcel.2004.08.008 · DOI · Paper page
  20. Karin, 2000, Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity, Annu. Rev. Immunol., 18, 621, 10.1146/annurev.immunol.18.1.621 · DOI · Paper page
  21. Karin, 2002, NF-kappaB at the crossroads of life and death, Nat. Immunol., 3, 221, 10.1038/ni0302-221 · DOI · Paper page
  22. Kelliher, 1998, The death domain kinase RIP mediates the TNF-induced NF-kappaB signal, Immunity, 8, 297, 10.1016/S1074-7613(00)80535-X · DOI · Paper page
  23. Kirisako, 2006, A ubiquitin ligase complex assembles linear polyubiquitin chains, EMBO J., 25, 4877, 10.1038/sj.emboj.7601360 · DOI · Paper page
  24. Komander, 2009, Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains, EMBO Rep., 10, 466, 10.1038/embor.2009.55 · DOI · Paper page
  25. Kovalenko, 2006, If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation, Mol. Cell, 22, 433, 10.1016/j.molcel.2006.05.002 · DOI
  26. Lee, 1997, TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival, Immunity, 7, 703, 10.1016/S1074-7613(00)80390-8 · DOI · Paper page
  27. Lo, 2009, Structural basis for recognition of diubiquitins by NEMO, Mol. Cell, 33, 602, 10.1016/j.molcel.2009.01.012 · DOI · Paper page
  28. Locksley, 2001, The TNF and TNF receptor superfamilies: integrating mammalian biology, Cell, 104, 487, 10.1016/S0092-8674(01)00237-9 · DOI · Paper page
  29. Lu, 2008, SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP, Cancer Res., 68, 9384, 10.1158/0008-5472.CAN-08-2655 · DOI
  30. Mace, 2008, Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment, J. Biol. Chem., 283, 31633, 10.1074/jbc.M804753200 · DOI
  31. Matsuzawa, 2008, Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex, Science, 321, 663, 10.1126/science.1157340 · DOI
  32. Park, 2004, Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro, FEBS Lett., 566, 151, 10.1016/j.febslet.2004.04.021 · DOI
  33. Pickart, 2004, Polyubiquitin chains: polymeric protein signals, Curr. Opin. Chem. Biol., 8, 610, 10.1016/j.cbpa.2004.09.009 · DOI · Paper page
  34. Pobezinskaya, 2008, The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors, Nat. Immunol., 9, 1047, 10.1038/ni.1639 · DOI
  35. Rahighi, 2009, Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation, Cell, 136, 1098, 10.1016/j.cell.2009.03.007 · DOI · Paper page
  36. Rigaut, 1999, A generic protein purification method for protein complex characterization and proteome exploration, Nat. Biotechnol., 17, 1030, 10.1038/13732 · DOI · Paper page
  37. Rothe, 1995, The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins, Cell, 83, 1243, 10.1016/0092-8674(95)90149-3 · DOI · Paper page
  38. Sato, 2005, Essential function for the kinase TAK1 in innate and adaptive immune responses, Nat. Immunol., 6, 1087, 10.1038/ni1255 · DOI · Paper page
  39. Schmidt-Supprian, 2000, NEMO/IKK gamma-deficient mice model incontinentia pigmenti, Mol. Cell, 5, 981, 10.1016/S1097-2765(00)80263-4 · DOI · Paper page
  40. Shim, 2005, TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo, Genes Dev., 19, 2668, 10.1101/gad.1360605 · DOI · Paper page
  41. Shu, 1996, The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex, Proc. Natl. Acad. Sci. USA, 93, 13973, 10.1073/pnas.93.24.13973 · DOI · Paper page
  42. Sun, 2007, Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP, J. Am. Chem. Soc., 129, 15279, 10.1021/ja074725f · DOI
  43. Tokunaga, 2009, Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation, Nat. Cell Biol., 11, 123, 10.1038/ncb1821 · DOI · Paper page
  44. Tsao, 2000, Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway, Mol. Cell, 5, 1051, 10.1016/S1097-2765(00)80270-1 · DOI
  45. Varfolomeev, 2008, c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation, J. Biol. Chem., 283, 24295, 10.1074/jbc.C800128200 · DOI · Paper page
  46. Vince, 2007, IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis, Cell, 131, 682, 10.1016/j.cell.2007.10.037 · DOI · Paper page
  47. Vince, 2009, TRAF2 must bind to cIAPs for TNF to efficiently activate NF-{kappa}B and to prevent TNF-induced apoptosis, J. Biol. Chem., 10.1074/jbc.M109.072256 · DOI
  48. Wajant, 2003, Tumor necrosis factor signaling, Cell Death Differ., 10, 45, 10.1038/sj.cdd.4401189 · DOI · Paper page
  49. Wallach, 1999, Tumor necrosis factor receptor and Fas signaling mechanisms, Annu. Rev. Immunol., 17, 331, 10.1146/annurev.immunol.17.1.331 · DOI · Paper page
  50. Wang, 2001, TAK1 is a ubiquitin-dependent kinase of MKK and IKK, Nature, 412, 346, 10.1038/35085597 · DOI · Paper page
  51. Wertz, 2004, De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling, Nature, 430, 694, 10.1038/nature02794 · DOI · Paper page
  52. Wong, 2009, RIPK1 is not essential for TNFR1 induced activation of NF-kappaB, Cell Death Differ.
  53. Wu, 2006, Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected], Nat. Cell Biol., 8, 398, 10.1038/ncb1384 · DOI · Paper page
  54. Yamamoto, 2006, Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling, Nat. Immunol., 7, 962, 10.1038/ni1367 · DOI · Paper page
  55. Yeh, 1997, Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice, Immunity, 7, 715, 10.1016/S1074-7613(00)80391-X · DOI · Paper page
  56. Yin, 2009, Structural basis for the lack of E2 interaction in the RING domain of TRAF2, Biochemistry, 48, 10558, 10.1021/bi901462e · DOI
  57. Zhou, 2004, Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO, Nature, 427, 167, 10.1038/nature02273 · DOI · Paper page

Cited by

See all 775

Metadata

Authors
Haas, T. L., Emmerich, C. H., Gerlach, B., Schmukle, A. C., Cordier, S. M., Rieser, E., Feltham, R., Vince, J., Warnken, U., Wenger, T., Koschny, R., Komander, D., Silke, J., & Walczak, H.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2009-12
Volume
36
Issue
5
Pages
831-844
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/j.molcel.2009.10.013
OpenAlex
W2166793740
Cited by
775
References
6
FWCI
12.34
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction. https://app.cochat.ai/papers/10.1016/j.molcel.2009.10.013
The paper
Haas, T. L., Emmerich, C. H., Gerlach, B., Schmukle, A. C., Cordier, S. M., Rieser, E., Feltham, R., Vince, J., Warnken, U., Wenger, T., Koschny, R., Komander, D., Silke, J., & Walczak, H. (2009). Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.10.013

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.