The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations
Open accessAbstract
Summary Cancer initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces widespread somatic mutation in mature B cells; however the extent of “off-target” DSB formation and its role in translocation-associated malignancy is unknown. Here we show that deregulated expression of AID causes widespread genome instability, which alone is insufficient to induce B cell lymphoma; transformation requires concomitant loss of the tumor suppressor p53. Mature B cell lymphomas arising as a result of deregulated AID expression are phenotypically diverse and harbor clonal reciprocal translocations involving a group of Immunoglobulin (Ig) and non-Ig genes which are direct targets of AID: this group includes miR-142, a previously unknown micro-RNA target which is translocated in human B cell malignancy. We conclude that AID produces DSBs throughout the genome, which can lead to lymphoma associated chromosome translocations in mature B cells.
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Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
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“This would be in keeping with p53’s ability to respond to oncogenic stress and induce the death of cells that overexpress oncogenes (Green and Kroemer, 2009; Hoffman and Liebermann, 2008; Kruse and Gu, 2009; Lowe et al., 2004).”
Cytoplasmic functions of the tumour suppressor p53
Green, D. R., & Kroemer, G. (2009) · Nature · doi:10.1038/nature07986 · Cited by 1,106
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1270 · Cited by 227
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Cited by
Aukema, S. M., Siebert, R., Schuuring, E., van Imhoff, G. W., Kluin-Nelemans, H. C., Boerma, E.-J., & Kluin, P. M. (2011) · Blood · doi:10.1182/blood-2010-09-297879 · Cited by 678
Lenz, G., & Staudt, L. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0807082 · Cited by 528
Aguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476
Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
Barlow, J. H., Faryabi, R. B., Callén, E., Wong, N., Malhowski, A., Chen, H. T., Gutierrez-Cruz, G., Sun, H.-W., McKinnon, P., Wright, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.006 · Cited by 444
Self-citationSchwickert, T. A., Victora, G. D., Fooksman, D. R., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., Dustin, M. L., & Nussenzweig, M. C. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102477 · Cited by 438
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Metadata
- Authors
- Robbiani, D. F., Bunting, S., Feldhahn, N., Bothmer, A., Camps, J., Deroubaix, S., McBride, K. M., Klein, I. A., Stone, G., Eisenreich, T. R., Ried, T., Nussenzweig, A., & Nussenzweig, M. C.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 36
- Issue
- 4
- Pages
- 631-641
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W1988202153
- Cited by
- 261
- References
- 5
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Robbiani, D. F., Bunting, S., Feldhahn, N., Bothmer, A., Camps, J., Deroubaix, S., McBride, K. M., Klein, I. A., Stone, G., Eisenreich, T. R., Ried, T., Nussenzweig, A., & Nussenzweig, M. C. (2009). AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.11.007
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