The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface
Open accessAbstract
Summary Accurate chromosome segregation requires carefully regulated interactions between kinetochores and microtubules, but how plasticity is achieved to correct diverse attachment defects remains unclear. Here, we demonstrate that Aurora B kinase phosphorylates three spatially distinct targets within the conserved outer kinetochore KNL1/Mis12 complex/Ndc80 complex (KMN) network, the key player in kinetochore-microtubule attachments. The combinatorial phosphorylation of the KMN network generates graded levels of microtubule binding activity, with full phosphorylation severely compromising microtubule binding. Altering the phosphorylation state of each protein causes corresponding chromosome segregation defects. Importantly, the spatial distribution of these targets along the kinetochore axis leads to their differential phosphorylation in response to changes in tension and attachment state. In total, rather than generating exclusively binary changes in microtubule binding, our results suggest a mechanism for the tension-dependent fine tuning of kinetochore-microtubule interactions.
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The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore
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Self-citationMolecular architecture of the kinetochore–microtubule interface
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Self-citationChromosomal passengers: conducting cell division
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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
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Kinetochore Microtubule Dynamics and Attachment Stability Are Regulated by Hec1
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Metadata
- Authors
- Welburn, J. P. I., Vleugel, M., Liu, D., Yates, J. R., Lampson, M. A., Fukagawa, T., & Cheeseman, I. M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 38
- Issue
- 3
- Pages
- 383-392
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2079900102
- Cited by
- 481
- References
- 26
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Welburn, J. P. I., Vleugel, M., Liu, D., Yates, J. R., Lampson, M. A., Fukagawa, T., & Cheeseman, I. M. (2010). Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.02.034
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