Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,839

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852

Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

Polyak, K., & Weinberg, R. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2620 · Cited by 3,302

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

Ben‐Porath, I., Thomson, M., Carey, V. J., Ge, R., Bell, G. W., Regev, A., & Weinberg, R. A. (2008) · Nature Genetics · doi:10.1038/ng.127 · Cited by 2,571

Polycomb complexes repress developmental regulators in murine embryonic stem cells

Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint

Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413

Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

Yu, F., Yao, H., Zhu, P., Zhang, X., Pan, Q., Gong, C., Huang, Y., Hu, X., Su, F., Lieberman, J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.054 · Cited by 1,906

Beyond EZH2: is the polycomb protein CBX2 an emerging target for anti-cancer therapy?

Jangal, M., Lebeau, B., & Witcher, M. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1627329 · Cited by 47

Targeting epigenetic machinery: Emerging novel allosteric inhibitors

Ye, F., Huang, J. L., Wang, H., Luo, C., & Zhao, K. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107406 · Cited by 47

The Regulatory Roles of Non-coding RNAs in Angiogenesis and Neovascularization From an Epigenetic Perspective

Hernández-Romero, I. A., Guerra-Calderas, L., Salgado-Albarrán, M., Maldonado-Huerta, T., & Soto‐Reyes, E. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01091 · Cited by 46

Integrins in mammary development

Raymond, K., Faraldo, M. M., Deugnier, M., & Glukhova, M. A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.03.008 · Cited by 46

Effects of miRNAs on functions of breast cancer stem cells and treatment of breast cancer

Zhang, Y., Xu, B., & Zhang, X. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s165156 · Cited by 44

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

Chang, W. H., & Lai, A. G. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1880-9 · Cited by 44

Network analysis of EMT and MET micro-RNA regulation in breast cancer

Garcia, D. D., Enríquez, J. E., & Lemus, E. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-13903-1 · Cited by 43

miR‐200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+ breast cancer

Tang, H., Song, C., Ye, F., Gao, G., Ou, X., Zhang, L., Xie, X., & Xie, X. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14681 · Cited by 43

Emerging role of G9a in cancer stemness and promises as a therapeutic target

Haebe, J. R., Bergin, C. J., Sandouka, T., & Benoit, Y. D. (2021) · Oncogenesis · doi:10.1038/s41389-021-00370-7 · Cited by 43

Delivery of miR-200c-3p Using Tumor-Targeted Mesoporous Silica Nanoparticles for Breast Cancer Therapy

Garrido‐Cano, I., Adam‐Artigues, A., Lameirinhas, A., Blandez, J. F., Candela‐Noguera, V., Lluch, A. M., Bermejo, B., Sancenón, F., Cejalvo, J. M., Martínez‐Máñez, R., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c07541 · Cited by 41

The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells

Zhao, Z., Li, S., Song, E., & Liu, S. (2015) · Protein & Cell · doi:10.1007/s13238-015-0199-4 · Cited by 42

Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12

Xie, Z., Cai, L., Li, R., Zheng, J., Wu, H., Yang, X., Li, H., & Wang, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-3340-3 · Cited by 41

Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through

Batista, L., Bourachot, B., Mateescu, B., Reyal, F., & Mechta‐Grigoriou, F. (2016) · Nature Communications · doi:10.1038/ncomms9959 · Cited by 41

MiR200 and miR302: Two Big Families Influencing Stem Cell Behavior

Balzano, F., Cruciani, S., Basoli, V., Santaniello, S., Facchin, F., Ventura, C., & Maioli, M. (2018) · Molecules · doi:10.3390/molecules23020282 · Cited by 41

SUZ12 Depletion Suppresses the Proliferation of Gastric Cancer Cells

Cui, Y., Chen, J., He, Z., & Xiao, Y. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350095 · Cited by 40

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

Szczepanek, J., & Tretyn, A. (2023) · Biomolecules · doi:10.3390/biom13111590 · Cited by 43

Emerging Role of MicroRNAs in Cancer and Cancer Stem Cells

Hao, J., Zhao, S., Zhang, Y., Zhao, Z., Ye, R., Wen, J., & Li, J. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24702 · Cited by 41

MicroRNA‐218 inhibits tumor growth and increases chemosensitivity to CDDP treatment by targeting BCAT1 in prostate cancer

Zhu, W., Shao, Y., & Peng, Y. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22612 · Cited by 39

Epigenetic Signaling of Cancer Stem Cells During Inflammation

Liu, Z., Ren, Y., Meng, L., Li, L., Beatson, R., Deng, J., Zhang, T., Liu, J., & Han, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.772211 · Cited by 42

RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer

Bracken, C. P., Goodall, G. J., & Gregory, P. A. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.06.001 · Cited by 43

Biological and clinical significance of cancer stem cell plasticity

Zhu, Y., Luo, M., Brooks, M. D., Clouthier, S. G., & Wicha, M. S. (2014) · Clinical and Translational Medicine · doi:10.1186/s40169-014-0032-3 · Cited by 39

MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small cell lung cancer.

You, J., Zhang, Y., Li, Y., Fang, N., Liu, B., Zu, L., & Zhou, Q. (2015) · Europe PMC (PubMed Central) · Cited by 39

Progesterone generates cancer stem cells through membrane progesterone receptor-triggered signaling in basal-like human mammary cells

Varès, G., Sai, S., Wang, B., Fujimori, A., Nenoi, M., & Nakajima, T. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.03.030 · Cited by 38

Molecular Pathways: Epigenetic Modulation of Wnt–Glycogen Synthase Kinase-3 Signaling to Target Human Cancer Stem Cells

Benoit, Y. D., Guezguez, B., Boyd, A. L., & Bhatia, M. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2491 · Cited by 40

miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma

Zhang, H., Alshareef, A., Wu, C., Jiao, J.-W., Sorensen, P. H. B., Lai, R. L., Xu, L., & Li, E. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw079 · Cited by 38

Therapeutic Potential of the miRNA–ATM Axis in the Management of Tumor Radioresistance

Rezaeian, A.-H., Khanbabaei, H., & Călin, G. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1807 · Cited by 40

Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

Prabhu, K. S., Raza, A., Karedath, T., Raza, S. S., Fathima, H., Ahmed, E. I., Kuttikrishnan, S., Therachiyil, L., Kuliński, M., Dermime, S., et al. (2020) · Cancers · doi:10.3390/cancers12020351 · Cited by 38

Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis

Bosch, A., Bertran, S., Lu, Y., Garcia, A., Jones, A. M., Dawson, M. I., & Farias, E. (2012) · Breast Cancer Research · doi:10.1186/bcr3247 · Cited by 37

c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis

Qu, Y., Yang, Q., Liu, J., Shi, B., Ji, M., Li, G., & Hou, P. (2017) · Theranostics · doi:10.7150/thno.19884 · Cited by 37

Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes

Hanin, G., & Soreq, H. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00028 · Cited by 36

EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization

Gallardo, A., Molina, A., Asenjo, H. G., López-Onieva, L., Martorell‐Marugán, J., Espinosa-Martínez, M., Griñán‐Lisón, C., Álvarez-Pérez, J. C., Cara, F. E., Navarro-Marchal, S. A., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02375-x · Cited by 39

Dual Effects of Non-Coding RNAs (ncRNAs) in Cancer Stem Cell Biology

Kyriazi, A. A., Papiris, E., Kitsos-Kalyvianakis, K., Sakellaris, G., & Baritaki, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186658 · Cited by 35

Antioxidants Maintain E-Cadherin Levels to Limit Drosophila Prohemocyte Differentiation

Gao, H., Wu, X., Simon, L., & Fossett, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107768 · Cited by 34

The miR-200b/200a/429 cluster prevents metastasis and induces dormancy in a murine claudin-low mammary tumor cell line

Watson, K. L. M., Jones, R. A., Bruce, A., & Moorehead, R. A. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.04.024 · Cited by 34

Histone Deacetylase 1/Sp1/MicroRNA-200b Signaling Accounts for Maintenance of Cancer Stem-Like Cells in Human Lung Adenocarcinoma

Chen, D., Huang, J., Feng, B. C., Pan, B., De, W., Wang, R., & Chen, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109578 · Cited by 33

Transcriptome-Wide Analysis of UTRs in Non-Small Cell Lung Cancer Reveals Cancer-Related Genes with SNV-Induced Changes on RNA Secondary Structure and miRNA Target Sites

Sabarinathan, R., Wenzel, A., Novotny, P., Tang, X., Kalari, K. R., & Gorodkin, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0082699 · Cited by 33

SUZ 12 is a novel putative oncogene promoting tumorigenesis in head and neck squamous cell carcinoma

Wu, Y., Hu, H., Zhang, W., Li, Z., Diao, P., Wang, D., Zhang, W., Wang, Y., Yang, J., & Cheng, J. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13638 · Cited by 41

MicroRNA regulation of epithelial plasticity in cancer

D’Amato, N. C., Howe, E. N., & Richer, J. K. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.054 · Cited by 32

Non-coding RNAs as emerging regulators of epithelial to mesenchymal transition in non-small cell lung cancer

Chen, Y., Lu, L., Feng, B., Han, S., Cui, S., Chu, X., Chen, L., & Wang, R. (2017) · Oncotarget · doi:10.18632/oncotarget.16375 · Cited by 32

Tumor-Suppressing Effects of miR-141 in Human Osteosarcoma

Xu, H., Mei, Q., Xiong, C., & Zhao, J. (2013) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9801-7 · Cited by 32

Stressed tumor cell, chemosensitized cancer

Wiemer, E. A. C. (2011) · Nature Medicine · doi:10.1038/nm.2593 · Cited by 32

Enhanced Chemosensitivity by Targeting Nanog in Head and Neck Squamous Cell Carcinomas

Huang, C.-E., Yu, C.-C., Hu, F., Chou, M. Y., & Tsai, L.-L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150914935 · Cited by 32

Tamoxifen induces a pluripotency signature in breast cancer cells and human tumors

Notas, G., Pelekanou, V., Kampa, M., Alexakis, K., Sfakianakis, S. G., Laliotis, A., Askoxilakis, J., Tsentelierou, E., Tzardi, M. N., Tsapis, A., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.05.008 · Cited by 31

Deregulation of Epigenetic Mechanisms by the Hepatitis B Virus X Protein in Hepatocarcinogenesis

ANDRISANI, O. M. (2013) · Viruses · doi:10.3390/v5030858 · Cited by 31

Non-coding RNAs in Mammary Gland Development and Disease

Sandhu, G. K., Milevskiy, M. J. G., Wilson, W. V., Shewan, A. M., & Brown, M. A. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7417-8_7 · Cited by 31

The Role of MicroRNAs in the Regulation of Gastric Cancer Stem Cells: A Meta-Analysis of the Current Status

Ruggieri, V., Russi, S., Zoppoli, P., Rocca, F. L., Angrisano, T., Falco, G., Calice, G., & Laurino, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050639 · Cited by 30

MicroRNAs, a Promising Target for Breast Cancer Stem Cells

Das, P. K., Siddika, M. A., Asha, S. Y., Aktar, S., Rakib, M. A., Khanam, J. A., Pillai, S., & Islam, F. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00439-5 · Cited by 30

MicroRNA142-3p Promotes Tumor-Initiating and Radioresistant Properties in Malignant Pediatric Brain Tumors

Lee, Y.-Y., Yang, Y.-P., Huang, M.-C., Wang, M., Yen, S.-H., Huang, P., Chen, Y., Chiou, S., Lan, Y., Ma, H.-I., et al. (2014) · Cell Transplantation · doi:10.3727/096368914x678364 · Cited by 30

microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance

Zhang, W. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236094 · Cited by 29

MiR-200a enhances the migrations of A549 and SK-MES-1 cells by regulating the expression of TSPAN1

Chen, Y., Peng, W., Lu, Y., Chen, J., Zhu, Y. Y., & Xi, T. (2013) · Journal of Biosciences · doi:10.1007/s12038-013-9351-6 · Cited by 29

MicroRNAs in Cholangiopathies

O’Hara, S. P., Gradilone, S. A., Masyuk, T. V., Tabibian, J. H., & LaRusso, N. F. (2014) · Current Pathobiology Reports · doi:10.1007/s40139-014-0048-9 · Cited by 28

Exploiting epigenetically mediated changes: Acute myeloid leukemia, leukemia stem cells and the bone marrow microenvironment

Kogan, A. A., Lapidus, R. G., Baer, M. R., & Rassool, F. V. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2018.12.005 · Cited by 28

miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12

Zhang, J., Xu, S., Xu, J., Li, Y., Zhang, J., Zhang, J., & Lu, X. (2019) · Oncology Reports · doi:10.3892/or.2019.7156 · Cited by 28

Identification of an Enhancer That Increases miR-200b~200a~429 Gene Expression in Breast Cancer Cells

Attema, J. L., Bert, A. G., Lim, Y., Kolesnikoff, N., Lawrence, D., Pillman, K. A., Smith, E., Drew, P. A., Khew‐Goodall, Y., Shannon, F. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075517 · Cited by 27

Nanosized Drug Delivery Systems for Breast Cancer Stem Cell Targeting

Lv, L., Shi, Y., Wu, J., & Li, G. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s282110 · Cited by 26

ER −/ PR + breast cancer: A distinct entity, which is morphologically and molecularly close to triple‐negative breast cancer

Beltjens, F., Molly, D., Bertaut, A., Richard, C., Desmoulins, I., Loustalot, C., Charon‐Barra, C., Courcet, E., Bergeron, A., Ladoire, S., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33539 · Cited by 26

Cancer stem cells: The potential of carbon ion beam radiation and new radiosensitizers (Review)

Baek, S.-J., Ishii, H., Tamari, K., Hayashi, K., Nishida, N., Konno, M., Kawamoto, K., Koseki, J., Fukusumi, T., Hasegawa, S., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.4236 · Cited by 26

Cancer Stem Cells in Breast Cancer

Takahashi, R., Takeshita, F., Fujiwara, T., Ono, M., & Ochiya, T. (2011) · Cancers · doi:10.3390/cancers3011311 · Cited by 25

miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer

Wu, S., Xie, J., Shi, H. S., & Wang, Z. (2020) · Bioscience Reports · doi:10.1042/bsr20194342 · Cited by 25

A novel miR-200c/c-myc negative regulatory feedback loop is essential to the EMT process, CSC biology and drug sensitivity in nasopharyngeal cancer

Yang, J., Wu, S.-P., Wang, W., Jin, Z.-R., Miao, X., Wu, Y., Gou, D., Liu, Q., & Yao, K. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111817 · Cited by 24

MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells

Wang, Z., Du, W.-J., Piazza, G. A., & Xi, Y. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.134 · Cited by 24

MicroRNA-200a Regulates Grb2 and Suppresses Differentiation of Mouse Embryonic Stem Cells into Endoderm and Mesoderm

Liu, Y., Liu, Q., Jia, W., Chen, J., Wang, J., Ye, D., Guo, X., Chen, W., Li, G., Wang, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068990 · Cited by 25

Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges

Dewi, D. L., Ishii, H., Kano, Y., Nishikawa, S., Haraguchi, N., Sakai, D., Satoh, T., Doki, Y., & Mori, M. (2011) · Journal of gastroenterology · doi:10.1007/s00535-011-0442-6 · Cited by 27

MicroRNAs horizon in retinoblastoma.

Mirakholi, M., Mahmoudi, T., & Heidari, M. (2013) · PubMed · Cited by 24

Regulating the Many to Benefit the Few: Role of Weak Small RNA Targets

Jost, D., Nowojewski, A., & Levine, E. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.02.020 · Cited by 23

PRC2 loss amplifies Ras signaling in cancer

Baude, A., Lindroth, A. M., & Plass, C. (2014) · Nature Genetics · doi:10.1038/ng.3124 · Cited by 23

Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation

Ji, Z., He, L., Rotem, A., Janzer, A., Cheng, C. S., Regev, A., & Struhl, K. (2018) · Nature Communications · doi:10.1038/s41467-018-04406-2 · Cited by 20

A phase I delayed-start, randomized and pharmacodynamic study of metformin and chemotherapy in patients with solid tumors

Saif, M. W., Rajagopal, S., Caplain, J., Grimm, E. A., Serebrennikova, O. B., Das, M., Tsichlis, P. N., & Martell, R. E. (2019) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-019-03967-3 · Cited by 24

miRNAs Highlights in Stem and Cancer Cells

Martignani, E., Miretti, S., Accornero, P., & Baratta, M. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711797655371 · Cited by 21

Stem cell MicroRNAs in senescence and immortalization: novel players in cancer therapy

Leal, J. A., Feliciano, A., & LLeonart, M. E. (2011) · Medicinal Research Reviews · doi:10.1002/med.20246 · Cited by 22

MicroRNA-200b suppresses cell invasion and metastasis by inhibiting the epithelial-mesenchymal transition in cervical carcinoma

CHENG, Y.-X., ZHANG, Q.-F., Li, H., Pan, F., HUANG, J.-L., LI, B.-S., & Hu, M. S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4911 · Cited by 21

MicroRNA-105 inhibits human glioma cell malignancy by directly targeting SUZ12

Zhang, J., Wu, W., Xu, S., Zhang, J., Zhang, J., Yu, Q., Jiao, Y., Wang, Y., Lu, A., You, Y., et al. (2017) · Tumor Biology · doi:10.1177/1010428317705766 · Cited by 21

A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence

Kooistra, S. M., Rudkjær, L. C. B., Lees, M. J., Steinhauer, C., Johansen, J. V., & Helin, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091034 · Cited by 21

Polycomb and Trithorax Group Proteins: The Long Road from Mutations in Drosophila to Use in Medicine

Chetverina, D., Ломаев, Д. В., & Erokhin, M. (2020) · Acta Naturae · doi:10.32607/actanaturae.11090 · Cited by 18

Critical Roles of Polycomb Repressive Complexes in Transcription and Cancer

Dong, G., Xu, J., Qi, Y.-R., Yuan, Z., & Zhao, W. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179574 · Cited by 21

Epigenetic control of immunoevasion in cancer stem cells

Galassi, C., Esteller, M., Vitale, I., & Galluzzi, L. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.08.004 · Cited by 20

Cancer stem cells and autophagy: Facts and Perspectives

Hamaï, A., Codogno, P., & Mehrpour, M. (2014) · Journal of Cancer Stem Cell Research · doi:10.14343/jcscr.2014.2e1005 · Cited by 20

Analysis of EZH2: micro-RNA network in low and high grade astrocytic tumors

Sharma, V., Purkait, S., Takkar, S., Malgulwar, P. B., Kumar, A., Pathak, P., Suri, V. S., Sharma, M. C., Suri, A., Kale, S. S., et al. (2016) · Brain Tumor Pathology · doi:10.1007/s10014-015-0245-1 · Cited by 19

Regulatory mechanisms of microRNAs in lung cancer stem cells

Fan, T. T., Wang, W., Zhang, B., Xu, Y., Chen, L., Pan, S., Hu, H., & Geng, Q. (2016) · SpringerPlus · doi:10.1186/s40064-016-3425-5 · Cited by 19

Polycomb repressor complex 2 function in breast cancer (Review)

Martin, C., & Moorehead, R. A. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5122 · Cited by 21

MicroRNA‑487b‑3p inhibits osteosarcoma chemoresistance and metastasis by targeting ALDH1A3

Cheng, M. L., Duan, P., Gao, Z., & Dai, M. (2020) · Oncology Reports · doi:10.3892/or.2020.7814 · Cited by 19

Targeted delivery of small noncoding RNA for glioblastoma

Yoo, J. Y., Yeh, M., Kaur, B., & Lee, T. J. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.004 · Cited by 19

Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies

Ali, K., Nabeel, M., Mohsin, F., Iqtedar, M., Islam, M. F., Rasool, M. F., Hashmi, F. K., Hussain, S. A., & Saeed, H. (2024) · Medical Oncology · doi:10.1007/s12032-024-02347-z · Cited by 21

A miR Image of Stem Cells and Their Lineages

Yi, R., & Fuchs, E. V. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387038-4.00007-0 · Cited by 17

Suppression of LPS-induced epithelial-mesenchymal transition by aqueous extracts of Prunella vulgaris through inhibition of the NF-κB/Snail signaling pathway and regulation of EMT-related protein expression

Cho, I.-H., Jang, E. H., Hong, D., Jung, B., Park, M., & Kim, J.-H. (2015) · Oncology Reports · doi:10.3892/or.2015.4218 · Cited by 17

The Role of Breast Cancer Stem Cell-Related Biomarkers as Prognostic Factors

Ko, C. C. H., Chia, W. K., Selvarajah, G. T., Cheah, Y. K., Wong, Y. P., & Tan, G. C. (2020) · Diagnostics · doi:10.3390/diagnostics10090721 · Cited by 16

Epigenetic regulators: Polycomb-miRNA circuits in cancer

de Nigris, F. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.03.005 · Cited by 16

Epigenetic Regulation of miRNAs and Breast Cancer Stem Cells

Duru, N., Gernapudi, R., Eades, G. L., Eckert, R. L., & Zhou, Q. Y. (2015) · Current Pharmacology Reports · doi:10.1007/s40495-015-0022-1 · Cited by 16

Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma

Hu, H., Wang, Y., Li, Z., Zhu, Y., Zhang, W., Wang, D., Lin, T., Yang, J., Wang, Y., & Cheng, J. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0395-9 · Cited by 16

Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development

Hwang, G.-R., Yuen, J. G., & Ju, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041624 · Cited by 15

PRC2 mediated KLF2 down regulation: a therapeutic and diagnostic axis during tumor progression

Taghehchian, N., Maharati, A., Akhlaghipour, I., Zangouei, A. S., & Moghbeli, M. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03086-3 · Cited by 15

MicroRNAs, a subpopulation of regulators, are involved in breast cancer progression through regulating breast cancer stem cells (Review)

Fan, X., Chen, W., Fu, Z., Zeng, L., Yin, Y., & Yuan, H. (2017) · Oncology Letters · doi:10.3892/ol.2017.6867 · Cited by 14

A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma

Ju, H., Zhang, L., Mao, L., Wu, Y., Liu, S., Ruan, M., Hu, J., & Ren, G. (2018) · Gene · doi:10.1016/j.gene.2018.06.064 · Cited by 14

Polyphenol-Enriched Blueberry Preparation Controls Breast Cancer Stem Cells by Targeting FOXO1 and miR-145

Mallet, J., Shahbazi, R., Alsadi, N., & Matar, C. (2021) · Molecules · doi:10.3390/molecules26144330 · Cited by 14

Biomarkers to Target Heterogeneous Breast Cancer Stem Cells

Hwang‐Verslues, W. W. (2012) · Journal of Molecular Biomarkers & Diagnosis · doi:10.4172/2155-9929.s8-006 · Cited by 14

A miR‐206 regulated gene landscape enhances mammary epithelial differentiation

Wang, J., Aydoğdu, E., Mukhopadhyay, S., Helguero, L. A., & Williams, C. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28789 · Cited by 14

A double-negative feedback loop between E2F3b and miR- 200b regulates docetaxel chemosensitivity of human lung adenocarcinoma cells

Gao, Y., Chen, L., Song, H., Chen, Y., Wang, R., & Feng, B. (2016) · Oncotarget · doi:10.18632/oncotarget.8376 · Cited by 13

MicroRNA-197 induces epithelial–mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma

Zhang, N., Tian, L., Miao, Z., & Guo, N. (2018) · Journal of Genetics · doi:10.1007/s12041-018-0881-4 · Cited by 13

Re-expression of miR-200s in claudin‐low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes

Simpson, K. E., Heumen, G. C.-V., Watson, K. L. M., Roth, M., Martin, C., & Moorehead, R. A. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01784-4 · Cited by 14

An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state

Polytarchou, C., Iliopoulos, D., & Struhl, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212811109 · Cited by 141

Differential expression of miR-200c in breast cancer stem cells.

Wu, D., Ji, N., Zhang, L., & Zhang, L. (2017) · PubMed Central · Cited by 2

The miR‐200b–ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma

Tsai, S., Lin, C., Shih, T., Tseng, R.-Y., Yu, M., Lin, Y., & Hsieh, S. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22657 · Cited by 48

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

Shimono, Y., Zabala, M., Cho, R. W., Lobo, N. A., Dalerba, P. D., Qian, D., Diehn, M., Liu, H., Panula, S., Chiao, E. T., et al. (2009) · Journal of End-to-End-testing · doi:10.1016/j.cell.2009.07.011 · Cited by 1,220

Abstract 2882: The miR-200b-ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma

Hsieh, S., & Tsai, S.-C. (2017) · Cancer Research · doi:10.1158/1538-7445.am2017-2882