Struhl, Kevin

Histone acetylation and transcriptional regulatory mechanisms

Struhl, K. (1998) · Genes & Development

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 1,815

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

Iliopoulos, D., Hirsch, H. A., & Struhl, K. (2009) · Cell

NF-κB Signaling PathwaysMicroRNA in disease regulation

Cited by 1,374

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N., & Struhl, K. (2009) · Cancer Research

Metabolism, Diabetes, and CancerCancer Cells and Metastasis

Cited by 1,115

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

Cawley, S., Bekiranov, S., Ng, H. H., Kapranov, P., Sekinger, E. A., Kampa, D., Piccolboni, A., Sementchenko, V., Cheng, J., Williams, A. J., et al. (2004) · Cell

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 1,095

The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

Ellenberger, T. E., Brandl, C. J., Struhl, K., & Harrison, S. C. (1992) · Cell

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 972

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

Iliopoulos, D., Jaeger, S. A., Hirsch, H. A., Bulyk, M. L., & Struhl, K. (2010) · Molecular Cell

MicroRNA in disease regulationCytokine Signaling Pathways and Interactions

Cited by 830

Metformin Inhibits the Inflammatory Response Associated With Cellular Transformation and Cancer Stem Cell Growth

Hirsch, H. A., Iliopoulos, D., & Struhl, K. (2013) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerNF-κB Signaling Pathways

Cited by 440

Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K. (2010) · Molecular Cell

MicroRNA in disease regulationCancer Cells and Metastasis

Cited by 399

Distinction and Relationship between Elongation Rate and Processivity of RNA Polymerase II In Vivo

Mason, P. B., & Struhl, K. (2005) · Molecular Cell

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 359

A nuclear receptor-like pathway regulating multidrug resistance in fungi

Thakur, J. K., Arthanari, H., Yang, F., Pan, S.-J., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D. K., Mylonakis, E., et al. (2008) · Nature

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 343

Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo

Kadosh, D., & Struhl, K. (1998) · Genes & Development

Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors Research

Cited by 234

The Swi/Snf Complex Is Important for Histone Eviction during Transcriptional Activation and RNA Polymerase II Elongation In Vivo

Schwabish, M. A., & Struhl, K. (2007) · Molecular and Cellular Biology

Chromatin Remodeling and CancerGenomics and Chromatin Dynamics

Cited by 158

YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

He, L., Pratt, H., Gao, M., Wei, F., Weng, Z., & Struhl, K. (2021) · eLife

Hippo pathway signaling and YAP/TAZGenomics and Chromatin Dynamics

Cited by 122

The transition from transcriptional initiation to elongation

Wade, J. T., & Struhl, K. (2008) · Current Opinion in Genetics & Development

Genomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Cited by 117

The transcriptional elongation rate regulates alternative polyadenylation in yeast

Geisberg, J. V., Moqtaderi, Z., & Struhl, K. (2020) · eLife

RNA Research and SplicingGenomics and Chromatin Dynamics

Cited by 45

STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer

Fleming, J. D., Giresi, P. G., Lindahl-Allen, M., Krall, E. B., Lieb, J. D., & Struhl, K. (2015) · Epigenetics & Chromatin

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 39