Cited by 400MicroRNA in disease regulationCancer Cells and MetastasisEpigenetics and DNA Methylation

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Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

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Iliopoulos, Dimitrios, Lindahl-Allen, Marianne, Polytarchou, Christos, Hirsch, Heather A., Tsichlis, Philip N., Struhl, Kevin·2010·Molecular Cell

DOI 10.1016/j.molcel.2010.08.013PMC PMC2938080

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Abstract

In an inducible oncogenesis model, the miR-200 family is inhibited during CSC formation but not transformation, and inhibition of miR-200b increases CSC formation. Interestingly, miR-200b directly targets Suz12, a subunit of a polycomb repressor complex (PRC2). Loss of miR-200 during CSC formation increases Suz12 expression, Suz12 binding, H3-K27 trimethylation, and Polycomb-mediated repression of the E-cadherin gene. miR-200b expression or Suz12 depletion blocks the formation and maintenance of mammospheres, and in combination with chemotherapy suppresses tumor growth and prolongs remission in mouse xenografts. Conversely, ectopic expression of Suz12 in transformed cells is sufficient to generate CSCs. The miR-200b-Suz12-cadherin pathway is important for CSC growth and invasive ability in genetically distinct breast cancer cells, and its transcriptional signature is observed in metastatic breast tumors. The interaction between miR-200 and Suz12 is highly conserved, suggesting that it represents an ancient regulatory mechanism to control the growth and function of stem cells.

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Gregory, P. A., Bert, A. G., Paterson, E. L., Barry, S. C., Tsykin, A., Farshid, G., Vadas, M. A., Khew‐Goodall, Y., & Goodall, G. J. (2008) · Nature Cell Biology · doi:10.1038/ncb1722 · Cited by 3,852
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Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
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Ben‐Porath, I., Thomson, M., Carey, V. J., Ge, R., Bell, G. W., Regev, A., & Weinberg, R. A. (2008) · Nature Genetics · doi:10.1038/ng.127 · Cited by 2,571
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Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cellsPreprint
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,413
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
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Yu, F., Yao, H., Zhu, P., Zhang, X., Pan, Q., Gong, C., Huang, Y., Hu, X., Su, F., Lieberman, J., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.054 · Cited by 1,906

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Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,208
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Jansson, M., & Lund, A. H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.09.006 · Cited by 1,150
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Phi, L. T. H., Sari, I. N., Yang, Y., Lee, S., Jun, N., Kim, K. S., Lee, Y. K., & Kwon, H. Y. (2018) · Stem Cells International · doi:10.1155/2018/5416923 · Cited by 1,061
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Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 994
Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links
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Authors: Iliopoulos, D., Lindahl-Allen, M., Polytarchou, C., Hirsch, H. A., Tsichlis, P. N., & Struhl, K.
Affiliations: Harvard University (US)
Tufts Medical Center (US)
Corresponding author: Struhl, Kevin
ORCID: Iliopoulos, Dimitrios
Polytarchou, Christos
Hirsch, Heather A.
Tsichlis, Philip N.
Struhl, Kevin
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2010-09
Volume: 39
Issue: 5
Pages: 761-772
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2010.08.013
PMC: PMC2938080
OpenAlex: W2050306367
Cited by: 399
References: 53
Citations by year: 2026: 6 · 2025: 9 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 21 · 2019: 29 · 2018: 16 · 2017: 24 · 2016: 23 · 2015: 34 · 2014: 51 · 2013: 52 · 2012: 41
FWCI: 14.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1050 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: China Scholarship Council
National Cancer Institute (R01CA107486, CA 57486, CA107486, R01CA057436)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: miR-200b, SUZ12, cancer stem cells, polycomb repressive complex 2, H3K27me3, E-cadherin, breast cancer, mammospheres, chemoresistance, metastasis, microRNA target regulation
MeSH terms: Animals, Breast Neoplasms, Carrier Proteins, Female, Humans, Mice, Nude, Neoplasm Proteins, Neoplasm Transplantation, Nuclear Proteins, Repressor Proteins, RNA, Neoplasm, Transcription Factors, Transplantation, Heterologous, Neoplastic Stem Cells, Cadherins, MicroRNAs, Cell Line, Tumor, Mice, Polycomb-Group Proteins, Polycomb Repressive Complex 2

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Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem Cells

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