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Cell Differentiation within a Yeast Colony: Metabolic and Regulatory Parallels with a Tumor-Affected Organism

Čáp, Michal, Štěpánek, Luděk, Harant, Karel, Váchová, Libuše, Palková, Zdena·2012·Molecular Cell
DOI 10.1016/j.molcel.2012.04.001
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Abstract

Nutrient sensing and metabolic reprogramming are crucial for metazoan cell aging and tumor growth. Here, we identify metabolic and regulatory parallels between a layered, multicellular yeast colony and a tumor-affected organism. During development, a yeast colony stratifies into U and L cells occupying the upper and lower colony regions, respectively. U cells activate a unique metabolism controlled by the glutamine-induced TOR pathway, amino acid-sensing systems (SPS and Gcn4p) and signaling from mitochondria with lowered respiration. These systems jointly modulate U cell physiology, which adapts to nutrient limitations and utilize the nutrients released from L cells. Stress-resistant U cells share metabolic pathways and other similar characteristics with tumor cells, including the ability to proliferate. L cells behave similarly to stressed and starving cells, which activate degradative mechanisms to provide nutrients to U cells. Our data suggest a nutrient flow between both cell types, resembling the Cori cycle and glutamine-NH(4)(+) shuttle between tumor and healthy metazoan cells.

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Metadata

Authors
Čáp, M., Štěpánek, L., Harant, K., Váchová, L., & Palková, Z.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2012-05
Volume
46
Issue
4
Pages
436-448
ISSN
1097-2765
DOI
10.1016/j.molcel.2012.04.001
Cited by
138
References
0
Language
en
Licence
Funders
  • Howard Hughes Medical Institute (55005623)
  • Grantová Agentura České Republiky (204/08/0718)
  • Ministry of Education (LC531, MSM0021620858, RVO 61388971)

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