The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Antibiotic-Induced Bacterial Cell Death Exhibits Physiological and Biochemical Hallmarks of Apoptosis
Open accessAbstract
Summary Programmed cell death is a gene-directed process involved in the development and homeostasis of multicellular organisms. The most common mode of programmed cell death is apoptosis, which is characterized by a stereotypical set of biochemical and morphological hallmarks. Here we report that Escherichia coli also exhibit characteristic markers of apoptosis – including phosphatidylserine exposure, chromosome condensation and DNA fragmentation – when faced with cell death-triggering stress, namely bactericidal antibiotic treatment. Notably, we also provide proteomic and genetic evidence for the ability of multifunctional RecA to bind peptide sequences that serve as substrates for eukaryotic caspases, and regulation of this phenotype by the protease, ClpXP, under conditions of cell death. Our findings illustrate that prokaryotic organisms possess mechanisms to dismantle and mark dying cells in response to diverse noxious stimuli, and suggest that elaborate, multilayered proteolytic regulation of these features may have evolved in eukaryotes to harness and exploit their deadly potential.
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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
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Triggering and modulation of apoptosis by oxidative stress
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Cited by
Post-stress bacterial cell death mediated by reactive oxygen species
Hong, Y., Zeng, J., Wang, X., Drlica, K., & Zhao, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901730116 · Cited by 513
Liao, S., Zhang, Y., Pan, X., Zhu, F., Jiang, C., Liu, Q., Cheng, Z., Dai, G., Wu, G., Wang, L., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s191340 · Cited by 499
Vilchèze, C., Hartman, T., Weinrick, B., & Jacobs, W. R. (2013) · Nature Communications · doi:10.1038/ncomms2898 · Cited by 334
Bacterial programmed cell death: making sense of a paradox
Bayles, K. W. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3136 · Cited by 315
Fungicidal Drugs Induce a Common Oxidative-Damage Cellular Death Pathway
Belenky, P., Camacho, D., & Collins, J. J. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.12.021 · Cited by 199
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Metadata
- Authors
- Dwyer, D. J., Camacho, D. M., Kohanski, M. A., Callura, J. M., & Collins, J. J.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 46
- Issue
- 5
- Pages
- 561-572
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2138826821
- Cited by
- 404
- References
- 5
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dwyer, D. J., Camacho, D. M., Kohanski, M. A., Callura, J. M., & Collins, J. J. (2012). Antibiotic-Induced Bacterial Cell Death Exhibits Physiological and Biochemical Hallmarks of Apoptosis. Molecular Cell. https://doi.org/10.1016/j.molcel.2012.04.027
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