The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction
Open accessAbstract
Drugs that kill tuberculosis more quickly could shorten chemotherapy significantly. In Escherichia coli, a common mechanism of cell death by bactericidal antibiotics involves the generation of highly reactive hydroxyl radicals via the Fenton reaction. Here we show that vitamin C, a compound known to drive the Fenton reaction, sterilizes cultures of drug-susceptible and drug-resistant Mycobacterium tuberculosis, the causative agent of tuberculosis. While M. tuberculosis is highly susceptible to killing by vitamin C, other Gram-positive and Gram-negative pathogens are not. The bactericidal activity of vitamin C against M. tuberculosis is dependent on high ferrous ion levels and reactive oxygen species production, and causes a pleiotropic effect affecting several biological processes. This study enlightens the possible benefits of adding vitamin C to an anti-tuberculosis regimen and suggests that the development of drugs that generate high oxidative burst could be of great use in tuberculosis treatment. New approaches to kill Mycobacterium tuberculosis are required to improve TB therapy. Vilchèze et al. now demonstrate that vitamin C-derived reactive oxygen species lead to sterilization of drug-susceptible and drug-resistant M. tuberculosisoffering new possibilities for drug development.
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Cites
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A major role for ferroptosis in Mycobacterium tuberculosis –induced cell death and tissue necrosis
Amaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L., Mayer-Barber, K. D., Andrade, B. B., & Sher, A. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181776 · Cited by 464
Effects of metabolites derived from gut microbiota and hosts on pathogens
Li, Z., Quan, G., Jiang, X., Yang, Y., Ding, X., Zhang, D., Wang, X., Hardwidge, P. R., Ren, W., & Zhu, G. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00314 · Cited by 157
Campos, A. I., & Zampieri, M. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.001 · Cited by 79
Chemistry and Redox Biology of Mycothiol
Reyes, A. M., Pedre, B., De Armas, M. I., Tossounian, M.-A., Radi, R., Messens, J., & Trujillo, M. (2018) · Antioxidants & Redox Signaling · doi:10.1089/ars.2017.7074 · Cited by 64
Metadata
- Authors
- Vilchèze, C., Hartman, T., Weinrick, B., & Jacobs, W. R.
- Venue
- Nature Communications
- Published
- 2013-05-21
- Volume
- 4
- Issue
- 1
- Pages
- 1881-1881
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2140867711
- Cited by
- 334
- References
- 40
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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