Cited by 340Cell death mechanisms and regulationFungal and yeast genetics researchUbiquitin and proteasome pathways

Yeast and apoptosis

Jin, Can, Reed, John C.·2002·Nature Reviews Molecular Cell Biology

Abstract

Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis proteins in yeast can help us to discover new genes -- and chemical compounds -- that modulate the cell-death pathways of higher eukaryotes.

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Crossref · 10.1038/nrm832

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Authors
Jin, C., & Reed, J. C.
Affiliations
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author
Reed, John C.
Venue
Nature Reviews Molecular Cell Biology
Published
2002-06
Volume
3
Issue
6
Pages
453-459
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W1502227906
Cited by
340
References
87
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 9 · 2013: 21 · 2012: 30
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
yeast, apoptosis, cell death pathways, gene discovery, Saccharomyces cerevisiae
MeSH terms
Animals, Mammals, Saccharomyces cerevisiae, Schizosaccharomyces, Yeasts, Apoptosis

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