The DOI matches its Crossref record; 229 of the 229 references it cites were found in a registry or an index.
Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Open accessAbstract
The physiological identity of every cell is maintained by highly specific transcriptional networks that establish a coherent molecular program that is in-tune with nutritional conditions. The regulation of cell-specific transcriptional networks is accomplished by an epigenetic program via chromatin modifying enzymes, whose activity is directly dependent on metabolites such as acetyl-CoA, S-adenosylmethionine and NAD+ among others. Therefore, these nuclear activities are directly influenced by the nutritional status of the cell. In addition to nutritional availability, this highly collaborative program between epigenetic dynamics and metabolism is further interconnected with other environmental cues provided by the day-night cycles imposed by circadian rhythms. Herein, we review molecular pathways and their metabolites associated with epigenetic adaptations modulated by histone- and DNA-modifying enzymes and their responsiveness to the environment in the context of health and disease.
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Cited by
Bile acid metabolites control TH17 and Treg cell differentiation
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LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
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Trained Immunity: Reprogramming Innate Immunity in Health and Disease
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Metadata
- Authors
- Etchegaray, J.-P., & Mostoslavsky, R.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 62
- Issue
- 5
- Pages
- 695-711
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2415515169
- Cited by
- 518
- References
- 229
- FWCI
- 17.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
