Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

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Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

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Yeast DNA Polymerase ε Participates in Leading-Strand DNA Replication

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Division of labor at the eukaryotic replication fork.

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Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

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Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

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Genome instability due to ribonucleotide incorporation into DNA

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Passing the baton in base excision repair.

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RNase H2-Initiated Ribonucleotide Excision Repair

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Functional sites of interaction between release factor RF1 and the ribosome.

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Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

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Choosing the right sugar: How polymerases select a nucleotide substrate

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RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

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Site-Specific Ribonuclease Activity of Eukaryotic DNA Topoisomerase I

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Erratum: DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination

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The Major Roles of DNA Polymerases Epsilon and Delta at the Eukaryotic Replication Fork Are Evolutionarily Conserved

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Saccharomyces cerevisiae RNase H(35) Functions in RNA Primer Removal during Lagging-Strand DNA Synthesis, Most Efficiently in Cooperation with Rad27 Nuclease

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Substrate Channeling in Mammalian Base Excision Repair Pathways: Passing the Baton

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Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

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Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

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Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA

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Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

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Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

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Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

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Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ɛ

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Balancing eukaryotic replication asymmetry with replication fidelity

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Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase α

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Mutational spectrum analysis of RNase H(35) deficient Saccharomyces cerevisiae using fluorescence-based directed termination PCR

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Interplay of DNA Repair Pathways Controls Methylation Damage Toxicity in Saccharomyces cerevisiae

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Causes and consequences of replication stress

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Human topoisomerases and their roles in genome stability and organization

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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

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Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

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Processing ribonucleotides incorporated during eukaryotic DNA replication

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DNA single-strand break repair

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Ribonucleotides in DNA: Origins, repair and consequences

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A global profile of replicative polymerase usage

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RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids

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Genome integrity and disease prevention in the nervous systemPreprint

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DNA Replication—A Matter of Fidelity

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Ribose-seq: global mapping of ribonucleotides embedded in genomic DNA

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Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

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Endogenous DNA 3′ Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease

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Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

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Sources of spontaneous mutagenesis in bacteria

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Recognition and repair of chemically heterogeneous structures at DNA ends

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DNA damage and transcription stress

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RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation

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Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

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The Balancing Act of Ribonucleotides in DNA

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Topoisomerase I‐mediated cleavage at unrepaired ribonucleotides generates DNA double‐strand breaks

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Elevated Genome-Wide Instability in Yeast Mutants Lacking RNase H Activity

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Nucleotide pools dictate the identity and frequency of ribonucleotide incorporation in mitochondrial DNA

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Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair

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Topoisomerase I Plays a Critical Role in Suppressing Genome Instability at a Highly Transcribed G-Quadruplex-Forming Sequence

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Ribose—An Internal Threat to DNA

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Topoisomerase I Alone Is Sufficient to Produce Short DNA Deletions and Can Also Reverse Nicks at Ribonucleotide Sites

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Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

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Mechanisms of damage tolerance and repair during DNA replication

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Genome instabilities arising from ribonucleotides in DNA

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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

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Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific

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Human DNA polymerase η has reverse transcriptase activity in cellular environments

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DNA Replication Error-Induced Extinction of Diploid Yeast

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High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication

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Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired

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Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq

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Stimulation of Chromosomal Rearrangements by Ribonucleotides

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Ribonuclease H2 in health and disease

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The Top1 paradox: Friend and foe of the eukaryotic genome

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Strand displacement synthesis by yeast DNA polymerase ε

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Arabidopsis thaliana RNase H2 Deficiency Counteracts the Needs for the WEE1 Checkpoint Kinase but Triggers Genome Instability

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RNA∶DNA Hybrids Initiate Quasi-Palindrome-Associated Mutations in Highly Transcribed Yeast DNA

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Mitochondrial DNA Instability in Mammalian Cells

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Measuring Ribonucleotide Incorporation into DNA In Vitro and In Vivo

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Ribonucleotides and Transcription-Associated Mutagenesis in Yeast

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