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Understanding Metabolic Regulation and Its Influence on Cell Physiology
Open accessAbstract
Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased exponentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.
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“Succinate inhibits HIF-1␣ signaling through inhibition of PHD2 but can also impact the activity of numerous ␣-ketoglutarate-dependent dioxygenases (42,43).”
From Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels (2016) · cites this paper as [43]
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Cites
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BackgroundCancer-associated IDH1 mutations produce 2-hydroxyglutarate
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A roadmap for interpreting 13C metabolite labeling patterns from cells
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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells
Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.008 · Cited by 562
Metadata
- Authors
- Metallo, C. M., & Vander Heiden, M. G.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Metallo, Christian M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 49
- Issue
- 3
- Pages
- 388-398
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC3569837
- OpenAlex
- W2024399152
- Cited by
- 367
- References
- 100
- Citations by year
- 2026: 26 · 2025: 39 · 2024: 36 · 2023: 24 · 2022: 25 · 2021: 37 · 2020: 35 · 2019: 31 · 2018: 25 · 2017: 16 · 2016: 19 · 2015: 24 · 2014: 23 · 2013: 6
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- American Cancer Society (70-002)
- Damon Runyon Cancer Research Foundation
- Richard and Susan Smith Family Foundation
- Burroughs Wellcome Fund
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- metabolic regulation, cell physiology, metabolic flux analysis, metabolic adaptation, metabolite quantification, metabolic disorders
- MeSH terms
- Animals, Cell Physiological Phenomena, Cells, Glycolysis, Humans, Models, Biological, Metabolic Networks and Pathways
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