Cited by 367Microbial Metabolic Engineering and BioproductionGene Regulatory Network AnalysisBioinformatics and Genomic Networks

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Understanding Metabolic Regulation and Its Influence on Cell Physiology

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Metallo, Christian M., Vander Heiden, Matthew G.·2013·Molecular Cell

DOI 10.1016/j.molcel.2013.01.018PMC PMC3569837

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Abstract

Metabolism impacts all cellular functions and plays a fundamental role in biology. In the last century, our knowledge of metabolic pathway architecture and the genomic landscape of disease has increased exponentially. Combined with these insights, advances in analytical methods for quantifying metabolites and systems approaches to analyze these data now provide powerful tools to study metabolic regulation. Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.

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Authors: Metallo, C. M., & Vander Heiden, M. G.
Affiliations: University of California San Diego (US)
Corresponding author: Metallo, Christian M.
ORCID: Metallo, Christian M.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2013-02
Volume: 49
Issue: 3
Pages: 388-398
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2013.01.018
PMC: PMC3569837
OpenAlex: W2024399152
Cited by: 367
References: 100
Citations by year: 2026: 26 · 2025: 39 · 2024: 36 · 2023: 24 · 2022: 25 · 2021: 37 · 2020: 35 · 2019: 31 · 2018: 25 · 2017: 16 · 2016: 19 · 2015: 24 · 2014: 23 · 2013: 6
FWCI: 2.26
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders: American Cancer Society (70-002)
Damon Runyon Cancer Research Foundation
Richard and Susan Smith Family Foundation
Burroughs Wellcome Fund
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Keywords: metabolic regulation, cell physiology, metabolic flux analysis, metabolic adaptation, metabolite quantification, metabolic disorders
MeSH terms: Animals, Cell Physiological Phenomena, Cells, Glycolysis, Humans, Models, Biological, Metabolic Networks and Pathways

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Understanding Metabolic Regulation and Its Influence on Cell Physiology

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