The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response
Open accessAbstract
SUMMARY Apoptosis is a highly regulated form of cell death that controls normal homeostasis as well as the anti-tumor activity of many chemotherapeutic agents. Commitment to death via the mitochondrial apoptotic pathway requires activation of the mitochondrial pore-forming proteins BAK or BAX. Activation can be effected by the activator BH3-only proteins BID or BIM, which have been considered to be functionally redundant in this role. Herein, we show that significant activation preferences exist between these proteins: BID preferentially activates BAK while BIM preferentially activates BAX. Furthermore, we find that cells lacking BAK are relatively resistant to agents that require BID activation for maximal induction of apoptosis including topoisomerase inhibitors and TRAIL. Consequently, patients with tumors that harbor a loss of BAK1 exhibit an inferior response to topoisomerase inhibitor treatment in the clinic. Therefore, BID and BIM have non-overlapping roles in the induction of apoptosis via BAK and BAX, affecting chemotherapy response.
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Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111
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BCL-2 family proteins: changing partners in the dance towards death
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Self-citationBax, Bak and beyond — mitochondrial performance in apoptosis
Peña‐Blanco, A., & García‐Sáez, A. J. (2018) · The FEBS Journal · doi:10.1111/febs.14186 · Cited by 930
Mitochondrial apoptosis: killing cancer using the enemy within
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Metadata
- Authors
- Sarosiek, K. A., Chi, X., Bachman, J. A., Sims, J. J., Montero, J., Patel, L., Flanagan, A., Andrews, D. W., Sorger, P., & Letai, A.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 51
- Issue
- 6
- Pages
- 751-765
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2165179086
- Cited by
- 247
- References
- 12
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sarosiek, K. A., Chi, X., Bachman, J. A., Sims, J. J., Montero, J., Patel, L., Flanagan, A., Andrews, D. W., Sorger, P., & Letai, A. (2013). BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.08.048
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