The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Translational Landscape of the Mammalian Cell Cycle
Open accessAbstract
Summary: Gene regulation during cell cycle progression is an intricately choreographed process, ensuring accurate DNA replication and division. However, the translational landscape of gene expression underlying cell cycle progression remains largely unknown. Here, employing genome-wide ribosome profiling we uncover widespread translational regulation of hundreds of mRNAs serving as an unexpected mechanism for gene regulation underlying cell cycle progression. A striking example is the S-phase translational regulation of RICTOR, which is associated with cell cycle-dependent activation of mTORC2 signaling and accurate cell cycle progression. We further identified unappreciated coordination in translational control of mRNAs within molecular complexes dedicated to cell cycle progression, lipid metabolism, and genome integrity. This includes the majority of mRNAs comprising the cohesin and condensin complexes, controlling genome organization, which are coordinately translationally controlled in specific cell cycle phases via their 5′ UTRs. Our findings illuminate the prevalence and dynamic nature of translational regulation underlying the mammalian cell cycle.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
The anaphase promoting complex/cyclosome: a machine designed to destroy
Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature · doi:10.1038/nature10912 · Cited by 1,313
Self-citationWapl controls the dynamic association of cohesin with chromatin
Kueng, S., Hegemann, B., Peters, B. H., Lipp, J. J., Schleiffer, A., Mechtler, K., & Peters, J.-M. (2006) · Cell · doi:10.1016/j.cell.2006.09.040 · Cited by 624
Transcriptional regulation and function during the human cell cycle
Cho, R. J., Huang, M., Campbell, M. J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S. J., Davis, R. W., & Lockhart, D. J. (2001) · Nature Genetics · doi:10.1038/83751 · Cited by 455
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The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity
Simsek, D., Tiu, G. C., Flynn, R. A., Byeon, G. W., Leppek, K., Xu, A. F., Chang, H. Y., & Barna, M. (2017) · Cell · doi:10.1016/j.cell.2017.05.022 · Cited by 439
Differential Requirements for eIF4E Dose in Normal Development and Cancer
Truitt, M. L., Conn, C. S., Shi, Z., Pang, X., Tokuyasu, T., Coady, A. M., Seo, Y., Barna, M., & Ruggero, D. (2015) · Cell · doi:10.1016/j.cell.2015.05.049 · Cited by 368
Self-citationRegulation of Poly(A) Tail and Translation during the Somatic Cell Cycle
Park, J.-E., Yi, H., Kim, Y., Chang, H., & Kim, V. N. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.007 · Cited by 202
The ribosome-engaged landscape of alternative splicing
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Metadata
- Authors
- Stumpf, C. R., Moreno, M. V., Olshen, A. B., Taylor, B. S., & Ruggero, D.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 52
- Issue
- 4
- Pages
- 574-582
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2105575738
- Cited by
- 207
- References
- 6
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stumpf, C. R., Moreno, M. V., Olshen, A. B., Taylor, B. S., & Ruggero, D. (2013). The Translational Landscape of the Mammalian Cell Cycle. Molecular Cell. https://doi.org/10.1016/j.molcel.2013.09.018
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